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  • Riboswitches: natural SELEXion.

    Cell Mol Life Sci. 62(21):2401-4. doi: 10.1007/s00018-005-5345-3. November 2005. View on PubMed.
  • Authors

    Gilbert SD and Batey RT
  • Abstract

    Advances in our knowledge of the structure and chemistry of RNA have been harnessed in the process known as SELEX to develop artificial RNA-based molecules that can act as enzymes and ligand binders performing a wide variety of functions. The discovery of riboswitches, natural RNA aptamers involved in genetic regulation, offers a basis of comparison between the artificial selection and the natural selection of structured RNAs for small-molecule recognition. The guanine riboswitch structural determination allows us to draw conclusions regarding the apparent increased complexity of the riboswitch aptamers compared to their in-vitro-selected cousins.

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