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Tangential Flow Filtration
Tangential flow filtration (TFF), or crossflow filtration, is a protein purification and concentration method to separate molecules based on size. In TFF, a feed solution is continuously passed across a porous membrane. Pressure is applied to the stream, toward the membrane, to force molecules smaller than the pore size through the membrane. Both the filtrate and the flow-through can be collected. Unlike direct flow filtration, any larger particles that cannot pass through the membrane are washed off the membrane in the continuous flow of the feed so they do not coat the membrane and inhibit separation. Considerations for TFF include the molecular weight of the molecule to be separated, the fluid characteristics of the feed, the required scale of the process, the purity of the final product desired, and the amount of product needed. TFF is used on a small scale for research applications like the concentration and purification of native and recombinant proteins and for antibody purification. On a large scale, TFF is used in drug manufacturing. (Credit: Brooke Anderson-White)
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