Chemical and Proteomic Mass Spectrometry Core Facility
at Virginia Commonwealth University
Richmond, Virginia, United States of America
3 HPLC-MS Orders8 Total Orders0 Endorsements
PhenoSwitch Bioscience - Expert services in mass spectrometry
Sherbrooke, Quebec, Canada
2 HPLC-MS Orders35 Total Orders0 Endorsements
Science Exchange Concierge
A dedicated scientist with a master's degree or PhD can identify the most qualified service providers for your project from our network of publicly and privately listed providers.
We found 6 results for HPLC-MS
For more results try searching for across all experimental services.
In high-performance liquid chromatography mass spectrometry (HPLC-MS), the separation capability of HPLC is coupled with mass analysis capability of mass spectrometry via a suitable interface such as electrospray ionization. Sample is introduced in the system through an injection port. A high pressure flow of solvent (mobile phase) makes the sample pass through a column packed with coated beads (stationary phase). As components in the sample are separated based on their relative affinity to stationary phase and mobile phase, they are introduced into the mass spectrometer, where they are ionized to produce charged molecules. These move through a vacuum chamber as they are accelerated with electric and magnetic fields, and arrive at the detector according to their mass-to-charge ratios. A mass spectrum is produced which is used for identification and quantification of the compounds in sample. Thermally labile compounds as well as those with very high polarity or high molecular mass are detected and analyzed using this setup. It is commonly used in proteomics analysis of post-translational modifications in proteins. (Credit: Muhammad Atif Khan )
Science Exchange is the fastest and safest way to order scientific services. All providers have passed a qualification process and agreed to pre-negotiated legal terms that protect your confidentiality and IP.