Consortium for the Construction, Equipping and Exploitation of the Synchrotron Light Laboratory (CELLS)
Cerdanyola del Valles, Barcelona, Spain
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By flash freezing samples, they can be imaged without having to be fixed and stained, procedures which can distort biological samples; thus, cryo-EM can produce better results for morphological studies. Freeze fracture (freeze-and-break) can be useful for imaging proteins embedded in cell membranes.
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