ZenBio
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Research Triangle Park, North Carolina, US
Zen-Bio, Inc. (ZB) is a leading global provider of advanced cell-based solutions and services to the life science, cosmetics, and personal care communities. The company, founded in 1995, was a pioneer in adipose derived stem cells (ASCs) and continues this legacy providing cutting edge human primary cell culture products and services. Our mission is to provide the highest quality human cell systems, reagents and contract services to our research partners, to develop and commercialize innovative research tools, leverage our expertise through research and development and strategic alliances, and accelerate discovery.
Custom Tissue Procurement Services
ZenBio offers cells, tissue, and serum from a diverse group of donor populations. Products are available from mixed donor lots, individual donor lots and a variety of disease states such as type II diabetes, hypertension, and others.
Customized Cell Solutions
ZenBio offers customers exceptional versatility in addressing specific project requirements with our robust custom cell-based assay development and services capabilities. Experience a seamless workflow... customized to meet your rigorous project needs.
Metabolic Disease Contracts
ZenBio offers a variety of assays to test compounds as potential diabetes or obesity therapies. Customers can choose from any of the following assays or we can design a custom program tailored to each client's specific research needs.
ZenSkin™ Products and Services
ZenBio has developed a dedicated solutions platform delivering products, services and expertise to assist in the emerging and diverse research field of skin. From initial donor-specific tissue acquisition to full thinkness skin testing or 3D skin equivalents, the ZenBio research team can deliver dermal research capabilities to accelerate client projects and meet objectives rapidly in a cost-effective approach minimizing time, and resources.
High Content Assay Development and Screening Services
ZenBio offers a variety of assays to using our ArrayScan XTI. Customers can choose from any of the following assays or we can design a custom program tailored to each client's specific research needs.
Human Tissue Derived products
ZenBio offers a variety of assays to using our ArrayScan XTI. Customers can choose from any of the following assays or we can design a custom program tailored to each client's specific research needs.
ZenBio offers customers exceptional versatility in addressing specific project requirements with our robust custom cell-based assay development and services capabilities. Experience a seamless workflow... customized to meet your rigorous project needs.
ZenBio offers cells, tissue, and serum from a diverse group of donor populations. Products are available from mixed donor lots, individual donor lots and a variety of disease states such as type II diabetes, hypertension, and others.
Diabetes is a prevalent metabolic disease affecting more than 25 million Americans. About 90% to 95% of patients have non-insulin dependent diabetes mellitus (NIDDM) or type II diabetes.
Lipolysis plays a central role in the regulation of energy balance. Lipolysis is the process in which triglycerides (TG) are hydrolyzed into glycerol and free fatty acids. This process releases free fatty acids (FFA) into the bloodstream where they may be either re-esterified by the adipocyte or travel to other tissues and exert other effects throughout the body. Elevated adipocyte lipolysis has been observed in obese and diabetic individuals (Arner 1996). Excessive free fatty acid production is believed to contribute to insulin resistance in skeletal muscle that is observed in obesity. Hormone sensitive lipase is the rate-limiting enzyme catalyzing triglyceride breakdown. Perilipins, one of the PAT (perilipins, adipophilin, TIP47 proteins) family of lipid-associated proteins, are implicated in adipocyte lipolysis by mediating the interaction of HSL with the triacylglycerol molecule (Brasaemle et al. 2004; reviewed in, Tansey et al. 2004.) The presence of these proteins corresponds to lipolytic stimulation in cultured adipocytes (Braemle et al. 2004).
Human Tissue Services
Cell-Based Screening Methods Services
Lipid accumulation assays provide the tools to study the compounds that stimulate cultured human adipocyte differentiation or lipogenesis. Such compounds may be PPAR. agonists or a combination of thiazolidinediones and glucocorticoids that are potentially useful in the treatment of diabetes. Our assays measure potential PPAR agonists or glucocorticoid analogs. Assays include cellular accumulation of lipid after proscribed periods of time in culture, with and without compounds of interest.
Human Pan-T Cells, Negatively Selection, 5 million
Drug Discovery & Development Services
Stable Cell Lines for High Throughput Screening
Liver specific exosome detection and biomarker detection (Exosome Isolation and Characterization)
Liver specific exosome detection (Exosome Isolation and Characterization)
Liver specific exosome detection by flow cytometry (Exosome Isolation and Characterization)
Fresh Human LeukoPak - Normal Full
Human Whole Blood & PBMCs Services
Antibody Services
Protein Services
Cell and Tissue Culture Services
RNA Services
Genotyping Services
DNA Services
Bioanalysis Services
Pharmacology Services
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