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Yecuris

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Tualatin, Oregon, US

About Yecuris

Founded: 2007 Type: Privately Held Size: 1-10 employees

Whether you are building innovative gene therapies, targeting NASH, creating the next cure for a liver disease, or testing your small molecule for metabolism or toxicology, you need real data from from real human hepatocytes as early as possible.

That’s why for more than a decade, researchers have trusted the FRG platform for their liver studies. Yecuris FRG are chimeric animal models with more than 70% of the liver replaced with human hepatocytes providing researchers with actionable insights into liver-specific questions at the cellular, tissue, and animal level.

Our Services (8)


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Human Hepatocytes

Starting at $850.00 per plate

Research scientists have long been forced to make compromises when choosing between fresh or frozen hepatocytes. No longer. You now have a new option.

So whether you are creating the next cure for infectious disease such as hepatitis or malaria, building innovative gene therapies, targeting NASH, or testing your small molecule for metabolism or toxicology, with HepaCur™ Fresh hepatocytes you get a uniquely better option for answering your liver-specific questions.

Available in quantities of 10m cells, available on a bi-weekly basis. Visit www.yecuris.com to explore the current availability for upcoming perfusions.

Available on the following plates ($850/ea):
6 well, 12 well, 24, well, 48 well or 96 well

Available in HCM suspension ($85/million cells) *Minimum order of 10 million cells.


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Animal Models of Disease

Price on request

Liver-Humanized Mouse Models of Disease Services

Custom hepatocyte transplants:

  • Use your current lot(s) of hepatocytes to humanize the FRG KO mouse and run human-relevant studies to test compounds
  • Use hepatocytes from donors that exhibit a variety of human liver diseases for modeling
  • Bank current hepatocyte lot(s) in the FRG KO mouse model for future studies or fresh hepatocyte perfusions


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Humanized Mouse Models

Starting at $3,500.00 per animal

Yecuris FRG® KO mice are a chimeric model with more than 70% of the liver replaced with human hepatocytes, providing researchers with actionable insights into liver-specific questions at the cellular, tissue, and animal level. These humanized mice are available from multiple qualified donors on C57BI/6 or NOD backgrounds.

We also offer mice repopulated with C57Bl/6 or NOD hepatocytes for use as controls, as well as custom transplants to suit your study needs.

Humanized Mouse Mouse Non-Alcoholic Steatohepatitis (NASH) Hemophilia A Malaria Hepatitis B Hepatitis C Biology Microbiology Pharmacology NTBC SMX/TMP Nitisinone Mice factor VIII Hepatology Infectious Disease Hematology Adenovirus FAH Human Non-human Show 22 more tags Show less

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Animal Models and Studies

Price on request

FRG KO liver-humanized Animal Models and Studies Services:

  • Gene editing/Gene therapy Targets in liver humanized FRG mice
  • Short and long-term viral hepatitis studies
  • NAFLD/NASH high fat diet studies using liver-humanized FRG mice
  • DMPK Studies
  • DDI Studies
  • iPSC & other stem cell studies

Non-Alcoholic Steatohepatitis (NASH) Malaria Hepatitis B Hepatitis C Biology Microbiology Pharmacology FRG NTBC Nitisinone Mice Humanized Mouse Mouse Show 13 more tags Show less

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Cryopreserved Human Hepatocytes

Starting at $850.00 per unit

HepaCur™ Cryopreserved human hepatocytes (3+ continuous donors available) isolated from humanized FRG KO mice. Cells are purified and cryopreserved prior to shipment in a Dewar dry shipping vessel.

5 million + viable hepatocytes per vial.


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Human Biospecimens

Price on request

Human Biospecimens Services. Liver, plasma, blood, sera, bile isolated from liver-humanized FRG KO mice


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Human Primary Cells

Starting at $1,000.00 per unit

Human Primary Cells Services. Donors matched to humanized mice (original donor cryopreserved lots).


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Biochemical Reagents

Price on request

Nitisinone (NTBC)

CuRx™ Nitisinone (NTBC): 0.1g, 1g, 10g – Validated in the FRG® KO Mouse and made in the USA.

0.1g = $150/ea
1.0g = $500/ea
10g = $4000/ea

Whether you have a colony of your own or are looking to run an in-house study, only CuRx™ reagents have been optimized and qualified for performance in the FRG® KO platform. These materials are in stock and available to ship with receipt of a purchase order.

CuRx™ uPA Liver Tx Enhancer (Adenovirus)

CuRx™ uPA Liver Tx Enhancer, 100 µL

Standard dosage of the Ad:uPA virus is 1.25e9/25 grams of body weight in 100µl of Sterile Saline for Injection approximately 24 hours prior to hepatocyte transplant. Yecuris recommends medial-orbital injection while the animal is under anesthesia as this provides a highly reproducible mechanism for complete inoculation.

Whether you have a colony of your own, or are looking to run a in-house studies, only CuRx™ reagents have been optimized and qualified for performance in the FRG® KO systems. These materials are in stock and available to ship with receipt of a purchase order.

CuRx™ SMX/TMP Antibiotic

CuRx™ SMX/TMP Antibiotic, 25 mL

Whether you have a colony of your own, or are looking to run a in-house studies, only CuRx™ reagents have been optimized and qualified for performance in the FRG® KO systems. These materials are in stock and available to ship with receipt of a purchase order.

NTBC Nitisinone Humanized Rat Humanized Mouse Mice Mouse Rat Show 7 more tags Show less

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FA

Franchesca Abeyta

Technical Specialist I
GB

Gregory Bial

Manager, Client Services
RC

Robert Copenhaver

Head of Portfolio and Program Management
KF

Katherine Forbes

Business Operations Assistant

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