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Xylyx Bio, Inc.

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Brooklyn, New York, US

About Xylyx Bio, Inc.

Xylyx Bio is harnessing the power of tissue-specific extracellular matrix, for both cell culture and tissue regeneration applications. By bringing the native in-vivo environment to the in-vitro setting, Xylyx Bio’s tissue-specific and disease-specific ECM substrates support cell culture... Show more »

Xylyx Bio is harnessing the power of tissue-specific extracellular matrix, for both cell culture and tissue regeneration applications. By bringing the native in-vivo environment to the in-vitro setting, Xylyx Bio’s tissue-specific and disease-specific ECM substrates support cell culture models that are significantly more predictive of human physiology and pathophysiology, thus facilitating acceleration of drug discovery and development. With the aim to support drug discovery and development for fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and non-alcoholic steatohepatitis (NASH), we have developed fibrosis-specific in-vitro substrates. 

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Our Services (20)


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Antifibrotic Activity Assays

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At Xylyx Bio, we have developed custom human derived, disease-specific ECM cell culture substrates as 2D and 3D cell-based assays for anti-fibrotic drug discovery. Our disease-specific ECM products are applicable across multiple stages of the early-stage drug discovery pipeline, from target selection and hit identification through lead identification and optimization.

At Xylyx Bio, we have developed custom human derived, disease-specific ECM cell culture substrates as 2D and 3D cell-based assays for anti-fibrotic drug discovery. Our disease-specific ECM products are applicable across multiple stages of the early-stage drug discovery pipeline, from target selection and hit identification through lead identification and optimization.

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2D Cell Culture

Price on request

NativeCoat™ ECM Surface Coating is a solubilized form of the extracellular matrix (ECM) from native organs. NativeCoat™ ECM Coatings contain tissue-specific ECM components and signals, including adhesion molecules, matricryptic peptides, and growth factors that recapitulate the native cell environment in vitro.

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NativeCoat™ ECM Surface Coating is a solubilized form of the extracellular matrix (ECM) from native organs. NativeCoat™ ECM Coatings contain tissue-specific ECM components and signals, including adhesion molecules, matricryptic peptides, and growth factors that recapitulate the native cell environment in vitro.

Apply NativeCoat™ ECM in 2D cell culture to coat any cell culture surface and provide cells with key physiological factors that regulate cell growth and function. Coating with tissue-specific biochemical composition of the native cell microenvironment results in increased cell attachment, viability and proliferation as well as enhanced function and activation of signaling pathways.
NativeCoat™ is also available from additional organs, specific tissue regions, and alternative sources, including human.

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Human Pig

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3D Cell Culture Kits

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Tissue-specific ECM Hydrogel is a versatile extracellular matrix product comprised of collagens and other ECM molecules of tissue-specific origin (porcine). TissueSpec® hydrogels provide cells a soft, physiologic substrate for 3D cell culture that is easy to use and enhances cell function and cell-cell interactions.

TissueSpec®... Show more »

Tissue-specific ECM Hydrogel is a versatile extracellular matrix product comprised of collagens and other ECM molecules of tissue-specific origin (porcine). TissueSpec® hydrogels provide cells a soft, physiologic substrate for 3D cell culture that is easy to use and enhances cell function and cell-cell interactions.

TissueSpec® Hydrogel can be applied as a thin gel on which to culture cells and study cell activity and function. Cells migrate into the hydrogel, enabling migration and invasion assays.
To study cell-cell interactions and microtissue structures, encapsulate and culture cells or organoids within 3D TissueSpec® Hydrogel.

TissueSpec® Hydrogel is available from additional organs, specific tissue regions, and alternative sources, including human.

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Human Pig

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Tissue Scaffolds

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TissueSpec® Scaffolds are custom acellular matrix substrates that retain the natural 3D structure, biomechanics, and topography of native tissues (porcine). Scaffolds contain tissue-specific features and architecture, for example, tubular structures of the renal medulla (TissueSpec® Kidney Scaffolds)
and hepatic sinusoids... Show more »

TissueSpec® Scaffolds are custom acellular matrix substrates that retain the natural 3D structure, biomechanics, and topography of native tissues (porcine). Scaffolds contain tissue-specific features and architecture, for example, tubular structures of the renal medulla (TissueSpec® Kidney Scaffolds)
and hepatic sinusoids (TissueSpec® Liver Scaffolds).

TissueSpec® Scaffold is available from additional organs, specific tissue regions, and alternative sources, including human.

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Human Pig

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Cell Culture Media and Reagents

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We offer tissue-specific extracellular matrix products to be used as media supplements.

We offer tissue-specific extracellular matrix products to be used as media supplements.

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Drug Target Identification

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Drug Discovery

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In vitro Disease Models

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3D Cell Culture Models

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Organotypic Cell Culture

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Mammalian Cell Culture

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Mammalian Cell Culture Services

Mammalian Cell Culture Services

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Drug Discovery & Development

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Drug Discovery & Development Services

Drug Discovery & Development Services

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Lead Identification and Validation

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Lead Identification and Validation Services

Lead Identification and Validation Services

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Stem Cell Differentiation

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Cell Culture Consulting

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Cell and Tissue Culture

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Primary Cell Culture

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Induced Pluripotent Stem Cell (iPSC) Differentiation

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Embryonic Stem Cell (ESC) Culture

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Induced Pluripotent Stem Cell (iPSC) Culture

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FileType/PDF Created with Sketch. Xylyx Bio_Product Brochure_032019.pdf

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FileType/PDF Created with Sketch. Xylyx Bio_Product Datasheet_NativeCoat™ ECM Surface Coatings.pdf

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FileType/PDF Created with Sketch. Xylyx Bio_Product Datasheet_TissueSpec® ECM Scaffold.pdf

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FileType/PDF Created with Sketch. Xylyx Bio_Product Datasheet_TissueSpec® Intestine ECM Hydrogel.pdf

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FileType/PDF Created with Sketch. Xylyx Bio_Product Datasheet_TissueSpec® Liver ECM Hydrogel.pdf

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FileType/PDF Created with Sketch. Xylyx Bio_Product Datasheet_TissueSpec® Lung ECM Hydrogel.pdf

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FileType/Other Created with Sketch. Xylyx Bio_Products Video.mp4

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