Xylyx Bio's mission is to increase predictiveness and confidence in drug discovery for cancer, fibrosis, and other devastating diseases through our physiologically-relevant IN MATRICO™ platform. Our platform technology incorporates human tissue and disease-specific extracellular matrix substrates combined with clinically relevant data packages to enable drug candidates to be tested IN MATRICO™ to inform better decision making in drug discovery.
Tissue-specific ECM substrates enable high-fidelity disease models that reflect human disease biology and are provided in both 2D and 3D product formats that are compatible with low and high throughput screening. Specifically within fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and non-alcoholic steatohepatitis (NASH), we have developed fibrosis-specific in-vitro ECM substrates and assays to support discovery of new treatments for patients.
Xylyx Bio also offers IN MATRICO™ compound testing services to accurately predict in-vivo drug response.
Recapitulation of complex cell-cell and cell-matrix interactions is key to identify drivers of metastasis and targets for therapeutic intervention. IN SITE™ Metastasis Kit contains bone, liver and lung ECMs that provide tissue-specific compositions and mechanics to model colonization of tumor cells in a secondary site
At Xylyx Bio, we have developed custom human derived, disease-specific ECM cell culture substrates as 2D and 3D cell-based assays for anti-fibrotic drug discovery. Our disease-specific ECM products are applicable across multiple stages of the early-stage drug discovery pipeline, from target selection and hit identification through lead identification and optimization.
NativeCoat™ ECM Surface Coating is a solubilized form of the extracellular matrix (ECM) from native organs. NativeCoat™ ECM Coatings contain tissue-specific ECM components and signals, including adhesion molecules, matricryptic peptides, and growth factors that recapitulate the native cell environment in vitro.
Apply NativeCoat™ ECM in 2D cell culture to coat any cell culture surface and provide cells with key physiological factors that regulate cell growth and function. Coating with tissue-specific biochemical composition of the native cell microenvironment results in increased cell attachment, viability and proliferation as well as enhanced function and activation of signaling pathways.
NativeCoat™ is also available from additional organs, specific tissue regions, and alternative sources, including human.
Tissue-specific ECM Hydrogel is a versatile extracellular matrix product comprised of collagens and other ECM molecules of tissue-specific origin (porcine). TissueSpec® hydrogels provide cells a soft, physiologic substrate for 3D cell culture that is easy to use and enhances cell function and cell-cell interactions.
TissueSpec® Hydrogel can be applied as a thin gel on which to culture cells and study cell activity and function. Cells migrate into the hydrogel, enabling migration and invasion assays.
To study cell-cell interactions and microtissue structures, encapsulate and culture cells or organoids within 3D TissueSpec® Hydrogel.
TissueSpec® Hydrogel is available from additional organs, specific tissue regions, and alternative sources, including human.
TissueSpec® Scaffolds are custom acellular matrix substrates that retain the natural 3D structure, biomechanics, and topography of native tissues (porcine). Scaffolds contain tissue-specific features and architecture, for example, tubular structures of the renal medulla (TissueSpec® Kidney Scaffolds)
and hepatic sinusoids (TissueSpec® Liver Scaffolds).
TissueSpec® Scaffold is available from additional organs, specific tissue regions, and alternative sources, including human.
We offer tissue-specific extracellular matrix products to be used as media supplements.
Lead Identification and Validation Services
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