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Xentech

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EVRY, FR

About Xentech

XenTech is a French company part of the top 10 preclinical CRO’s active in oncology offering support to early drug development. Our services are governed by a stringent QA system (“GLP-like”).

XenTech’s technology is based on one of the world’s largest and best characterized collection of Patient-Derived primary tumor Xenograft models (PDX). Our panel includes exclusive pediatric models, resistant "Match-R" models. We also offer immuno-oncology dedicated panel.

Our ambition is to foster therapeutic development in Oncology by offering an innovative translational platform, developing clinically relevant tumor models and addressing tomorrow’s needs in preclinical oncology research.

Our Services (57)


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Pancreas Patient Derived Xenograft (PDX)

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Biomarker Discovery

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XenTech’s PDX platform is an outstanding tool for cancer biomarker discovery.

Large tumor panels recapitulate the biological heterogeneity of patient populations, a key parameter for the evaluation of molecular targeted agents.
Indeed, tumor xenografts of the same histological subtype often demonstrate highly variable responses, as seen in cancer patients.

This variability creates an opportunity to identify biomarkers associated with resistance or response to therapy by cross-matching PDX drug response profiles and molecular data (mutations, gene copy number, gene or protein expression data, miRNA data).

These cancer biomarkers can be used :

  • to select the right patient population for clinical trials (patients’ stratification).
  • to predict the clinical outcome for a patient (good or poor prognosis).
  • to help doctors to determine the most efficient treatment to be given to a specific patient: personalized medicine (theranostics).


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Patient-Derived Xenograft (PDX)

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Our large PDX platform is dedicated to evaluate antitumor efficacy and to discover predictive biomarker in support of subsequent companion diagnostic development.

We have gathered one of the most diverse collection of highly characterized PDX models for solid tumors in various indications with a World leading collection for Breast cancers and pediatric models in-between others.
Cell lines derived from our PDX have also recently been made available for in vitro assays.

PDX collection

CANCER TYPE SUBTYPES
Breast TNBC, HER2+, ER+, PR+
Colorectal -
Lung NSCLC, SCLC
Prostate Primary hormone-dependent, Hormone-independent variant
Brain Glioblastoma
Kidney Renal Cell Carcinoma (RCC)
Pancreas -
Skin Melanoma, Merkel cell carcinoma
Ovary -
Endometrium -
Liposarcoma -
Pediatric liver tumors Hepatoblastoma, Rhabdoid tumor
Neuroblastoma

Patient Derived Xenograft (PDX) Services : Maximum Tolerated Dose (MTD), Efficacy studies, Residual disease models,...

Breast cancer Bladder cancer Lung Cancer Prostate Cancer Melanoma Pancreatic cancer Liver cancer Immuno-Oncology Ovarian Cancer Sarcoma Drug Discovery FFPE tissue Frozen Tissue Blood Mouse Humanized Mouse Oncology Immunology Show 18 more tags Show less

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Xenograft Models

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Xenograft Models Services. In addition to our in vivo direct PDX models, we also can run in vivo studies with any type of cell line injection.


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Oncology Animal Models

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Oncology Animal Models Services


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Biomarkers

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Biomarkers Services


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Pharmacology & Toxicology

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Pharmacology & Toxicology Services


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Animal Models of Disease

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Animal Models of Disease Services


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Animal Models and Studies

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Animal Models and Studies Services


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Medical Imaging Services

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Lung Patient Derived Xenograft (PDX)

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Liver Cancer Patient Derived Xenograft (PDX)

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Kidney Patient Derived Xenograft (PDX)

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Endometrium Patient Derived Xenograft (PDX)

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Colorectal Patient Derived Xenograft (PDX)

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Breast Patient Derived Xenograft (PDX)

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Brain Patient Derived Xenograft (PDX)

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Bioanalysis

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Bioanalysis Services


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Clinical Research

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Animal Model in vivo Analyses

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Biology

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Biology Services


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In vivo Drug Efficacy Testing

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Drug Discovery & Development

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Drug Discovery & Development Services


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Pharmacology

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Pharmacology Services


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In vivo Pharmacology Studies

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In vivo Pharmacology Studies Services


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Biomarker Analysis

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Human Tumor Xenograft Models

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Humanized Mouse Models

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Animal Model Housing and Maintenance

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Immunology Animal Models

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Custom Oncology Animal Models

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Bladder Patient Derived Xenograft (PDX)

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Colon Patient Derived Xenograft (PDX)

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Melanoma Patient Derived Xenograft (PDX)

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Metastatic Carcinoma Patient Derived Xenograft (PDX)

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Ovary Patient Derived Xenograft (PDX)

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Sarcoma Patient Derived Xenograft (PDX)

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Metastatic Tumor Animal Models

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Brain Xenograft

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Colon Xenograft

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Ovarian Xenograft

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Pancreas Xenograft

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Prostate Xenograft

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Uterine Xenograft

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Rhabdomyosarcoma Xenograft

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Bladder Xenograft

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Breast Xenograft

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Cervical Patient Derived Xenograft (PDX)

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Lung Cancer Animal Models

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Endometrial Xenograft

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Cell Line Derived Xenograft (CDX) Models

Cell Line Derived Xenograft Models
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Adrenal Gland Xenograft

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Prostate Cancer Animal Models

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Breast Cancer Animal Models

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Glioma Xenograft

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Osteosarcoma Xenograft

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Xenograft Development

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