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Xentech

EVRY, FR

XenTech is a French company part of the top 10 preclinical CRO’s active in oncology offering support to early drug development. Our services are governed by a stringent QA system (“GLP-like”).

XenTech’s technology is based on one of the world’s largest and best characterized collection of Patient-Derived primary tumor Xenograft models (PDX).

Our ambition is to foster therapeutic development in Oncology by offering an innovative translational platform, developing clinically relevant tumor models and addressing tomorrow’s needs in preclinical oncology research.

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Pancreas Patient Derived Xenograft (PDX)
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Biomarker Discovery
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XenTech’s PDX platform is an outstanding tool for cancer biomarker discovery.

Large tumor panels recapitulate the biological heterogeneity of patient populations, a key parameter for the evaluation of molecular targeted agents.
Indeed, tumor xenografts of the same histological subtype often demonstrate highly variable... Show more »

XenTech’s PDX platform is an outstanding tool for cancer biomarker discovery.

Large tumor panels recapitulate the biological heterogeneity of patient populations, a key parameter for the evaluation of molecular targeted agents.
Indeed, tumor xenografts of the same histological subtype often demonstrate highly variable responses, as seen in cancer patients.

This variability creates an opportunity to identify biomarkers associated with resistance or response to therapy by cross-matching PDX drug response profiles and molecular data (mutations, gene copy number, gene or protein expression data, miRNA data).

These cancer biomarkers can be used :

  • to select the right patient population for clinical trials (patients’ stratification).
  • to predict the clinical outcome for a patient (good or poor prognosis).
  • to help doctors to determine the most efficient treatment to be given to a specific patient: personalized medicine (theranostics).
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Patient Derived Xenograft (PDX)
Price on request

Our large PDX platform is dedicated to evaluate antitumor efficacy and to discover predictive biomarker in support of subsequent companion diagnostic development.

We have gathered one of the most diverse collection of highly characterized PDX models for solid tumors in various indications with a World leading collection for... Show more »

Our large PDX platform is dedicated to evaluate antitumor efficacy and to discover predictive biomarker in support of subsequent companion diagnostic development.

We have gathered one of the most diverse collection of highly characterized PDX models for solid tumors in various indications with a World leading collection for Breast cancers and pediatric models in-between others.
Cell lines derived from our PDX have also recently been made available for in vitro assays.

PDX collection

CANCER TYPE SUBTYPES
Breast TNBC, HER2+, ER+, PR+
Colorectal -
Lung NSCLC, SCLC
Prostate Primary hormone-dependent, Hormone-independent variant
Brain Glioblastoma
Kidney Renal Cell Carcinoma (RCC)
Pancreas -
Skin Melanoma, Merkel cell carcinoma
Ovary -
Endometrium -
Liposarcoma -
Pediatric liver tumors Hepatoblastoma, Rhabdoid tumor

Neuroblastoma

Patient Derived Xenograft (PDX) Services : Maximum Tolerated Dose (MTD), Efficacy studies, Residual disease models,...

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Mouse
Cancer
Humanized mouse
Sarcoma
FFPE tissue
Drug discovery
Frozen Tissue
Immunooncology
immune checkpoint
Prostate Cancer
Breast Cancer
Cancer
Tissue Block
Lung Cancer
Ovarian Cancer
Melanoma Skin Cancer
Pancreatic cancer
Liver cancer
Fresh Frozen
anti-cancer
bladder cancer
Peripheral Blood
FFPE
Xenograft Models
Price on request

Xenograft Models Services. In addition to our in vivo direct PDX models, we also can run in vivo studies with any type of cell line injection.

Xenograft Models Services. In addition to our in vivo direct PDX models, we also can run in vivo studies with any type of cell line injection.

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Oncology Animal Models
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Oncology Animal Models Services

Oncology Animal Models Services

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Biomarkers
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Biomarkers Services

Biomarkers Services

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Pharmacology & Toxicology
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Pharmacology & Toxicology Services

Pharmacology & Toxicology Services

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Animal Models of Disease
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Animal Models of Disease Services

Animal Models of Disease Services

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Animal Models and Studies
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Animal Models and Studies Services

Animal Models and Studies Services

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Clinical Imaging Services
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Lung Patient Derived Xenograft (PDX)
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Liver Cancer Patient Derived Xenograft (PDX)
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Kidney Patient Derived Xenograft (PDX)
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Endometrium Patient Derived Xenograft (PDX)
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Colorectal Patient Derived Xenograft (PDX)
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Breast Patient Derived Xenograft (PDX)
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Brain Patient Derived Xenograft (PDX)
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Bioanalysis
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Bioanalysis Services

Bioanalysis Services

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Clinical Research
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