O2vrzekitbeptcalwnjn xell

Xell AG

No Reviews Yet
1 Order Completed
Bielefeld, DE

About Xell AG

Xell is an experienced partner for companies in the biotech and pharmaceutical industry providing highly-efficient solutions in cell culture technology. Meeting our customers’ specific needs is the objective of our dedicated team – our personal approach to challenging tasks is key to our success.

With years... Show more »

Xell is an experienced partner for companies in the biotech and pharmaceutical industry providing highly-efficient solutions in cell culture technology. Meeting our customers’ specific needs is the objective of our dedicated team – our personal approach to challenging tasks is key to our success.

With years of industry experience, we bring our extensive expertise in ultra-high performance media and feed development, and apply our powerful analytical tools for in-depth characterization of biological systems and pharmaceutical proteins, guaranteeing optimal solutions for our customers’ bioprocesses.

Show less

Our Services (8)


ic

Free Amino Acid Analysis

Price on request

UPLC-based quantitation of free proteinogenic and non-proteinogenic amino acids, including:

  • alanine
  • arginine
  • asparagine
  • aspartate
  • citrulline
  • cystin/cysteine*
  • glutamate
  • glutamine
  • glycine
  • histidine
  • hydroxyproline
  • isoleucine
  • leucine
  • lysine
  • methionine
  • ornithine
  • phenylalanine
  • proline
  • serine
    -... Show more »

UPLC-based quantitation of free proteinogenic and non-proteinogenic amino acids, including:

  • alanine
  • arginine
  • asparagine
  • aspartate
  • citrulline
  • cystin/cysteine*
  • glutamate
  • glutamine
  • glycine
  • histidine
  • hydroxyproline
  • isoleucine
  • leucine
  • lysine
  • methionine
  • ornithine
  • phenylalanine
  • proline
  • serine
  • taurine
  • threonine
  • tryptophane
  • tyrosine
  • valine

Standard Sample Preparation:

  1. Centrifuge an appropriate volume of fresh cell culture sample for 5-10 min at 200 x g.

  2. Filter supernatant with a 0.2 µm filter into an appropriate tube/container.

  3. Store your samples at -20 °C.

Standard Sample Requirements:
• Your samples have to be free of bacterial and viral contamination.
• Your samples have to be non-hazardous and classified as Biosafety Level 1.
• Please attach the sample declaration sheet to your samples.
• Most samples should be sent frozen on dry ice/wet ice!
• For accurate information on how and where to send your samples please contact us.

Approximate turnaround time: 2-3 weeks

Deliverables:
A short report with absolute amino acid concentrations will be provided. Free cysteine usually oxidizes rapidly to form cystine in aqueous solutions such as cell culture media samples. We will provide a quantitative value for the cystine concentration, and a relative concentration for cysteine if detectable.

Prices: We offer graduated prices, depending on the actual amount of samples.

Show less

ic

Spent Media Analysis

Price on request

As a cell culture media company, we routinely use a broad range of analytical methods for the quantitation of cell culture media constituents and metabolites. Our portfolio of fast and accurate quantitation methods covers the following substance classes:

  • Amino acids (proteogenic, non-proteogenic)
  • Ammonium
  • Ascorbate (vitamin... Show more »

As a cell culture media company, we routinely use a broad range of analytical methods for the quantitation of cell culture media constituents and metabolites. Our portfolio of fast and accurate quantitation methods covers the following substance classes:

  • Amino acids (proteogenic, non-proteogenic)
  • Ammonium
  • Ascorbate (vitamin C)
  • Glucose and lactate
  • Water-soluble vitamins (choline, folate, panthothenate, biotin, thiamine, etc.)
  • Inorganic anions (chloride, sulfate, phosphate, etc.)
  • Inorganic cations (sodium, potassium, calcium, magnesium, etc.)
  • Pyruvate and other organic acids
  • Saccharides (galactose, mannose, saccharose, etc.)
Show less

ic

Protein Characterization

Price on request

The analysis of product quantity and quality is the most important benchmark for a biological production process. Monitoring and maintaining the stability and consistency of these factors is essential when designing new media or processes.

We can provide you with a broad range of product analytics:

The analysis of product quantity and quality is the most important benchmark for a biological production process. Monitoring and maintaining the stability and consistency of these factors is essential when designing new media or processes.

We can provide you with a broad range of product analytics:

  • Protein quantitation (SEC, RP, AC, SDS-PAGE, etc.)
  • Protein characterization (peptide mapping, lysine clipping, glyco analysis, etc.)
Show less

ic

Cell Line Characterization

Price on request

With our broad range of analytical methods, we offer detailed characterization of your cell lines. Selection pressure and cell line stability are possible issues to be addressed. Depending on the culture medium, the concentration of selection reagents may need to be adapted to guarantee stable production while maintaining high... Show more »

With our broad range of analytical methods, we offer detailed characterization of your cell lines. Selection pressure and cell line stability are possible issues to be addressed. Depending on the culture medium, the concentration of selection reagents may need to be adapted to guarantee stable production while maintaining high process performance. Furthermore, we recommend the evaluation of long-term stability, which can be critical when extended seed-train periods are necessary.

Show less

ic

Physicochemical Testing

Price on request

We offer physico-chemial analysis of cell culture media and feeds:

  • pH
  • Turbitiy
  • Osmolality
  • Redox potential
  • Moisture in powder
  • Powder particle size distribution

We offer physico-chemial analysis of cell culture media and feeds:

  • pH
  • Turbitiy
  • Osmolality
  • Redox potential
  • Moisture in powder
  • Powder particle size distribution
Show less

ic

Raw Material Testing

Price on request

In general, raw materials and medium manufacturer are crucial factors influencing the quality of the final medium product. On the one hand, raw materials can vary due to production and origin. On the other hand, manufacturers differ in their production technology and raw material supply chain. As a result, the same medium... Show more »

In general, raw materials and medium manufacturer are crucial factors influencing the quality of the final medium product. On the one hand, raw materials can vary due to production and origin. On the other hand, manufacturers differ in their production technology and raw material supply chain. As a result, the same medium formulation can lead to deviating process performances.

It is therefore recommended to test several raw material sources and to compare different suppliers. We offer respective biological testing of potential raw materials and evaluation of products from different suppliers with regard to process performance and production. Powder and liquid media characterization as well as solubility studies of your products are also part of our portfolio.

Show less

ic

Batch Release Testing

Price on request

Lot-to-lot variation is a well-known effect in media production and can occur even in chemically defined media. It can be caused e.g. by minor changes in the powder production process or the solubilization procedure. Furthermore, lot-to-lot variation can occur due to impurities in raw materials.

For example, components such as... Show more »

Lot-to-lot variation is a well-known effect in media production and can occur even in chemically defined media. It can be caused e.g. by minor changes in the powder production process or the solubilization procedure. Furthermore, lot-to-lot variation can occur due to impurities in raw materials.

For example, components such as amino acids in USP/pharma grade with ≥ 98-99% purity may still contain foreign amino acids and trace metals. To evaluate variation in your media lots, we highly recommend biological performance tests. For that, we can establish and perform respective lot testing.

Show less

ic

Vitamin Measurement in Animal Samples

Price on request

HPLC-MS-based quantitation of water-soluble vitamins, vitaminoids and precursors*, including:

  • Vitamin B1 (thiamine)
  • Vitamin B2 (riboflavin)
  • Vitamin B3 (nicotinamid)
  • Vitamin B5 (calcium pantothenate)
  • Vitamin B6 (pyridoxal, pyridoxine)
  • Vitamin B7 (biotin)
  • Vitamin B9 (folic acid, aminobenzoic acid*)
  • Vitamin B12... Show more »

HPLC-MS-based quantitation of water-soluble vitamins, vitaminoids and precursors*, including:

  • Vitamin B1 (thiamine)
  • Vitamin B2 (riboflavin)
  • Vitamin B3 (nicotinamid)
  • Vitamin B5 (calcium pantothenate)
  • Vitamin B6 (pyridoxal, pyridoxine)
  • Vitamin B7 (biotin)
  • Vitamin B9 (folic acid, aminobenzoic acid*)
  • Vitamin B12 (cyanocobalamin)
  • Vitaminoids (choline chloride)

Standard Sample Preparation:

  1. Centrifuge an appropriate volume of fresh cell culture sample for 5-10 min at 200 x g.

  2. Filter supernatant with a 0.2 µm filter into an appropriate tube/container.

  3. Store your samples at -20 °C.

Standard Sample Requirements:

  • Your samples have to be free of bacterial and viral contamination.
  • Your samples have to be non-hazardous and classified as Biosafety Level 1
  • Please attach the sample declaration sheet to your samples
  • Most samples should be sent frozen on dry ice/wet ice!
  • For more information on how and where to send your samples, please contact us

Approximate turnaround time: 2-3 weeks

Deliverables:
A short report with absolute concentrations of the target compounds listed above will be provided.

Prices: We offer graduated prices, depending on the actual amount of samples.

Ascorbate Analysis

HPLC-MS-based quantitation of ascorbic acid / ascorbate / vitamin C

Standard Sample Preparation:

  1. Centrifuge an appropriate volume of fresh cell culture sample for 5-10 min at 200 x g.

  2. Filter supernatant with a 0.2 µm filter into an appropriate tube/container.

  3. Store your samples at -20 °C.

Standard Sample Requirements:

  • Your samples have to be free of bacterial and viral contamination
  • Your samples have to be non-hazardous and classified as Biosafety Level 1
  • Please attach the sample declaration sheet to your samples
  • Most samples should be sent frozen on dry ice/wet ice!
  • For more information on how and where to send your samples, please contact us

Approximate turnaround time: 2-3 weeks

Deliverables:
A short report with the absolute ascorbate concentration(s) will be provided.

Prices: We offer graduated prices, depending on the actual amount of samples.

Show less
Vitamin B12 Mass Spectrometry Liquid Chromatography cell culture supernatant

Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.
Missing Avatar

Lara Riedel

Sales Manager / Scientist
Missing Avatar

Tim Steffens

Business Development/ Scientist

Xell AG has not received any reviews.

Xell AG has not received any endorsements.