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Xell AG

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Bielefeld, DE

About Xell AG

Xell is an experienced partner for companies in the biotech and pharmaceutical industry providing highly-efficient solutions in cell culture technology. Meeting our customers’ specific needs is the objective of our dedicated team – our personal approach to challenging tasks is key to our success. With years of industry experience, we bring our extensive expertise in ultra-high performance media and feed development, and apply our powerful analytical tools for in-depth characterization of biological systems and pharmaceutical proteins, guaranteeing optimal solutions for our customers’ bioprocesses. We are ISO 9001 certified.

Certifications & Qualifications

ISO 9001

Our Services (13)


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HPLC-MS/MS

High Performance Liquid Chromatography Coupled Tandem Mass Spectrometry
Price on request

Small peptide analysis

UHPLC-MS/MS-based measurement of small peptides (e.g. dipeptides) from cell culture media supernatant
 
Standard Sample Requirements: 

• For instructions on sample preparation see our sample preparation protocol.

• Samples have to be free of bacterial and viral contamination and non-hazardous and classified as Biosafety Level 1. 

• Please attach the sample declaration sheet. 

Sample shipping costs: borne by customer 

Turnaround time: appr. 2-3 weeks 

Deliverables: short report on the results

Graduate prices: depending on the actual number of samples e.g. 50+ samples 136.00 USD/sample


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ICP-MS

Inductively Coupled Plasma Mass Spectrometry
Price on request

ICP-MS based analysis of ions, including:
• sodium

• phosphate

• calcium

• magnesium

 

Matrices: spent media and feed, food and animal feed samples

Standard Sample Requirements: 

• For instructions on sample preparation contact us or see our sample preparation protocol.

• Samples have to be free of bacterial and viral contamination and non-hazardous and classified as Biosafety Level 1. 

• Please attach the sample declaration sheet. 

• For shipping instructions please contact us. 

Sample shipping costs: borne by customer 

Turnaround time: appr. 2-3 weeks 

Deliverables: short report on the results

Graduate prices: Depending on the actual number of samples e.g. 50+ samples 50.40 USD/sample


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Antibody Validation

Price on request

Our HPLC method for quantification of antibodies is based on protein A affinity chromatography.
If you are unsure whether your antibody can be measured using protein A affinity.

Standard Sample Requirements: 

• For instructions on sample preparation see our sample preparation protocol.

• Samples have to be free of bacterial and viral contamination and non-hazardous and classified as Biosafety Level 1. 

• Please attach the sample declaration sheet. 

Sample shipping costs: borne by customer 

Turnaround time: appr. 2-3 weeks 

Deliverables: short report on the results

Graduate prices: depending on the actual number of samples e.g. 50+ samples 48.10 USD/sample


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Hydrolyzed Amino Acid Analysis

Starting at $169.10 per sample

Our UHPLC method will be applied after HCl hydrolysis and appropriate sample preparation to perform hydrolyzed amino acid anaylsis.

 

Matrices: spent media and feed, food and animal feed samples

Standard Sample Requirements: 

• For instructions on sample preparation see our sample preparation protocol.

• Samples have to be free of bacterial and viral contamination and non-hazardous and classified as Biosafety Level 1. 

• Please attach the sample declaration sheet

 

Sample shipping costs: borne by customer 

Turnaround time: appr. 2-3 weeks 

Deliverables: short report on the results

Graduate prices: depending on the actual number of samples e.g. 50+ samples 89.60 USD/sample

ISO 9001 Agilent Agilent 1290 UHPLC animal feed food spent media Show 6 more tags Show less

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Vitamin Content Determination

Starting at $222.80 per sample

UHPLC-based quantitation of water-soluble vitamins, vitaminoids and precursors*, including:

Vitamin B1 (thiamine) Vitamin B2 (riboflavin) Vitamin B3 (nicotinamid)
Vitamin B5 (calcium pantothenate) Vitamin B6 (pyridoxal, pyridoxine) Vitamin B7 (biotin)
Vitamin B9 (folic acid, aminobenzoic acid*) Vitamin B12 (cyanocobalamin) Vitaminoids (choline chloride)

Matrices: spent media and feed, food and animal feed samples

Standard Sample Requirements: 

• For instructions on sample preparation see our sample preparation protocol.

• Samples have to be free of bacterial and viral contamination and non-hazardous and classified as Biosafety Level 1. 

• Please attach the sample declaration sheet

Sample shipping costs: borne by customer 

Turnaround time: appr. 2-3 weeks 

Deliverables: short report on the results

Graduate prices: Depending on the actual number of samples e.g. 50+ samples 185.90 USD/sample

Agilent 1290 UHPLC Agilent spent media food animal feed Agilent 6470 triple quad MS Show 6 more tags Show less

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Trace Metal Analysis

Starting at $134.40 per sample

ICP-MS-based determination of trace elements, including:

Chromium (Cr) Manganese (Mn) Iron (Fe) Cobald (Co) Nickel (Ni)
Copper (Cu) Zinc (Zn) Selenium (Se) Molybdenum (Mo) Cadmium (Cd)

Additional elements on request.  

Matrices: spent media and feed, food and animal feed samples

Standard Sample Requirements: 

• For instructions on sample preparation see our sample preparation protocol.

• Samples have to be free of bacterial and viral contamination and non-hazardous and classified as Biosafety Level 1. 

• Please attach the sample declaration sheet

 

Sample shipping costs: borne by customer 

Turnaround time: appr. 2-3 weeks 

Deliverables: short report on the results

ICP-MS spent media food animal feed Agilent 7800 ICP-MS Agilent Show 6 more tags Show less

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Free Amino Acid Analysis

Starting at $123.20 per sample

UHPLC-based quantitation of free proteinogenic and non-proteinogenic amino acids, including

alanine  arginine  arginine 
aspartate  citrulline  cystin/cysteine*
glutamate  glutamine  glycine 
histidine  hydroxyproline  isoleucine 
leucine  lysine  methionine 
ornithine  phenylalanine  proline 
serine  taurine  threonine 
tryptophane  tyrosine  valine 

*Free cysteine usually oxidizes rapidly to form cystine in aqueous solutions such as cell culture media samples. We will provide a quantitative value for the cystine concentration, and a relative concentration for cysteine if detectable. 

 

Matrices: spent media and feed, food and animal feed samples

Standard Sample Requirements: 

• For instructions on sample preparation see our sample preparation protocol.

• Samples have to be free of bacterial and viral contamination and non-hazardous and classified as Biosafety Level 1. 

• Please attach the sample declaration sheet

 

Sample shipping costs: borne by customer 

Turnaround time: appr. 2-3 weeks 

Deliverables: short report on the results

Graduate prices: depending on actual amount of samples e.g. 50+ samples 61.60 USD/sample

 

Agilent 1290 UHPLC Amino Acid Analysis Agilent spent media food animal feed Show 6 more tags Show less

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Spent Media Analysis

Starting at $413.20 per sample

As a cell culture media company, we routinely use a broad range of analytical methods for the quantitation of cell culture media constituents and metabolites. Out of our extensive portfolio, we selected a group of highly informative parameters and created for you the culture media analysis bundle. It includes the analysis of:

• glucose and lactate

• amino acids

• water-soluble vitamins

• trace elements

 

Further parameters available on request.

 

Standard Sample Requirements: 

• For instructions on sample preparation contact us or see our sample preparation protocol.

• Samples have to be free of bacterial and viral contamination and non-hazardous and classified as Biosafety Level 1. 

• Please attach the sample declaration sheet

• For shipping instructions please contact us

Sample shipping costs: borne by customer 

Turnaround time: appr. 2-3 weeks 

Deliverables: short report on the results

Graduate prices: Depending on the actual number of samples e.g. 50+ samples 313.50 USD/sample

spent media

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Protein Characterization

Price on request

The analysis of product quantity and quality is the most important benchmark for a biological production process. Monitoring and maintaining the stability and consistency of these factors is essential when designing new media or processes.

We can provide you with a broad range of product analytics:

  • Protein quantitation (SEC, RP, AC, SDS-PAGE, etc.)
  • Protein characterization (peptide mapping, lysine clipping, glyco analysis, etc.)


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Cell Line Characterization

Price on request

With our broad range of analytical methods, we offer detailed characterization of your cell lines. Selection pressure and cell line stability are possible issues to be addressed. Depending on the culture medium, the concentration of selection reagents may need to be adapted to guarantee stable production while maintaining high process performance. Furthermore, we recommend the evaluation of long-term stability, which can be critical when extended seed-train periods are necessary.


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Physicochemical Testing

Price on request

We offer physico-chemial analysis of cell culture media and feeds:

  • pH
  • Turbitiy
  • Osmolality
  • Redox potential
  • Moisture in powder
  • Powder particle size distribution


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Raw Material Testing

Price on request

In general, raw materials and medium manufacturer are crucial factors influencing the quality of the final medium product. On the one hand, raw materials can vary due to production and origin. On the other hand, manufacturers differ in their production technology and raw material supply chain. As a result, the same medium formulation can lead to deviating process performances.

It is therefore recommended to test several raw material sources and to compare different suppliers. We offer respective biological testing of potential raw materials and evaluation of products from different suppliers with regard to process performance and production. Powder and liquid media characterization as well as solubility studies of your products are also part of our portfolio.


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Batch Release Testing

Price on request

Lot-to-lot variation is a well-known effect in media production and can occur even in chemically defined media. It can be caused e.g. by minor changes in the powder production process or the solubilization procedure. Furthermore, lot-to-lot variation can occur due to impurities in raw materials.

For example, components such as amino acids in USP/pharma grade with ≥ 98-99% purity may still contain foreign amino acids and trace metals. To evaluate variation in your media lots, we highly recommend biological performance tests. For that, we can establish and perform respective lot testing.


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LR

Lara Riedel

Sales Manager / Scientist
TS

Tim Steffens

Business Development/ Scientist

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