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Genuity Science

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Boston, Massachusetts, US

About Genuity Science

Genuity Science (formerly WuXi NextCODE) is a contract genomics and data-sourcing, –analytics and –insights organization headquartered in Boston, Massachusetts, USA with offices in Dublin, Ireland, and Reykjavik, Iceland. Genuity partners with global biopharma companies to offer deep end-to-end discovery services aimed at catalyzing precision health and improving the quality of life for patients around the world. Services include population-scale, disease-specific data sourcing, high-quality sequencing, robust statistical analysis, and software tools for analyzing large datasets and artificial intelligence (AI). The company operates advanced CAP/CLIA genomics laboratories in Woburn, Massachusetts, USA, and in Dublin, Ireland, and is deeply committed to data stewardship and data governance across its global offices. For more information, see www.genuitysci.com.

Our Services (32)


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Biomarkers

Price on request

TruSight Oncology 500 - DNA and RNA and TruSight Oncology 500 -DNA only available 


  • 523 cancer relevant genes (DNA) and 55 genes for aberrant transcripts (RNA)
  • Optimized for FFPE tumor tissue samples — no germline control samples are required 
  • Combined workflow and simultaneous analysis for RNA and DNA means you use the same sample in a single assay — only 40 ng DNA & 40 ng RNA input required from FFPE tissue 
  • Reduced sequencing error rates through the addition of unique molecular identifiers (UMIs) during library preparation coupled with Illumina’s proprietary informatics pipelines 
  • Distributable kit that is being developed as a companion diagnostic tool 
  • Assesses multiple variant types in a single assay including Small Nucleotide Variants (SNVs), InDels, splice variants, fusions, and emerging immunotherapy biomarkers that rely on analysis of multiple genomic loci, such as Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI) 
  • Delivers accurate quantitative MSI status vs traditional qualitative PCR and immunohistochemistry methodologies 
  • Reproducibly detects 5% variant allele frequency (VAF) in FFPE samples


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DNA Extraction

Price on request

Isolation of genomic DNA from multiple raw input materials. The product includes sample receipt, DNA extraction, and DNA QC.


Whole Blood Sample Requirement:

Standard - 3 ml whole blood

Minimum - 1.5 ml whole blood

Isolation Kit Used - Maxwell RSC Whole Blood DNA Kit

Isolation Kit Used - Autogen Fresh-Frozen Blood Kit


Cell Sample Requirement:

Standard: >=1x106 cells/sample

Isolation Kit Used - Maxweel RSC cell culture DNA kit


Fresh Tissue Sample Requirement:

Standard: ≥10mg fresh tissues, cut immediately into small pieces with dimension < 0.5 cm2.

Isolation Kit Used - Maxwell RSC Tissue DNA kit


Saliva Sample Requirement:

Standard: Oragene 600 tube with 3-4 ml of saliva

Isolation Kit Used - FlexSTAR Oragene Saliva Kit


Deliverables

Sample QC report


Turnaround time

1 week from sample receipt when the sample number is <200 a batch

2 weeks from sample receipt when sample numbers are between 200-400 a batch.

Genomics Blood FFPE tissue Cells Fresh Tissue saliva Human Show 7 more tags Show less

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Whole Genome Sequencing

Price on request

Whole Genome Sequencing of gDNA using Illumina's TruSeq DNA PCR-Free Library Kit.

PE 150 sequencing on a NovaSeq 6000 sequencer. 


Sample Requirement:

Standard: 2μg gDNA in 100μl TE

Minimum: 1μg gDNA in 100μl TE


Data yields: 

30x coverage; >90Gb Total PF data

Data QC criteria: average Q30 > 90%


60x coverage; >180Gb Total PF data

Data QC criteria: average Q30 > 90%


Deliverables:

FASTQ Files

Sample QC Report

Data QC Report

gDNA DNA Human

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Whole Genome Sequencing Data Analysis

Price on request

BAM and VCF File generation for Data files from 30x – 70x WGS data


Standard Pipeline Components:

• FASTQ Quality: FASTQC v0.11.7

• Phred scores per base: BBmap v37.97

• Alignment: Sentieon v201808.03 - BWA

• Mark Duplicates: Sentieon v201808.03 – Dedup

• Coverage Depth: Sentieon v201808.03 - WGSMetricsAlgo

• Somatic Variant Calling (SNVs/InDels): Sentieon v201808.03 - Realigner, QualCal, TNsnv (Sentieon MuTect counterpart), TNscope (Sentieon Tumor caller)


Reference Genomes:

• hg38


Deliverables:

• BAM Alignment File

• Variant (SNP/Indel) VCF files

• Raw output files from the above methods



Advanced Germline Pipeline Details:

• Adaptor Trimming: Skewer v0.2.1

• Coverage Depth: Sentieon v201808.03 - HSMetricsAlgo or WGSMetricsAlgo

• Mark Duplicates: Sentieon v201808.03 - markduplication

• Variant Calling: Sentieon v201808.03 - Realigner, QualCal, Haplotyper, GVCFtyper


Deliverables:

1. BAM Alignment File

2. Variant (SNP/Indel) VCF files

3. Raw output files from the above methods

Human

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Whole Exome Sequencing (WES)

Price on request

Whole Exome Sequencing, PE 150 sequencing on a NovaSeq 6000 Sequencer using the Exome Capture Kit Agilent SureSelect Human All Exon V6 kit.  


Sample  Requirement:

For DNA extracted from FFPE or Fresh Frozen Tissue

Standard: 2μg in 50μl

Minimum: 500 ng in 50μl


For DNA extracted from Blood

Standard: 4μg in 100μl

Minimum: 4μg in 100μl


Data yields:

50x coverage; >7Gb Total PF data

Data QC criteria: average Q30 > 90%


100x average on-target coverage; output >13G PF data

Data QC criteria: average Q30 > 90%


200x average on-target coverage; output > 22G PF data

Data QC criteria: average Q30 > 90%


300x coverage; >39Gb Total PF data

Data QC criteria: average Q30 > 90%


Deliverables:

FASTQ File(s),

Sample QC Report,

Data QC Report


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Whole Exome Sequencing Data Analysis

Price on request
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PBMC Isolation

Peripheral Blood Mononuclear Cell Isolation
Price on request
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Single Cell RNA-Seq

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Single Cell Isolation

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Single-Cell Sequencing Library Preparation

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Single Cell Sequencing Data Analysis

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Single Cell Gene Expression Analysis

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Statistical Analysis

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Machine Learning and AI Solutions

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Protein-DNA Interaction Analysis

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NGS Data Analysis

Next generation sequencing data analysis
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DNA Microarrays

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Bioinformatics Data Analysis

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Data Analysis

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Database Management Software

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Genome-Wide Association Studies

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Big Data Analytics and Consulting

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Computational Systems Biology

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Clinical Genomic Testing

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Biomarker Clinical Utility

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Biochemistry & Molecular Biology

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Epigenetic Studies

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Biomarker Discovery

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Microsatellite Instability Testing

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In silico Genomics/Transcriptomics Analysis

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Pharmacogenomics/Pharmacogenetics

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Real-World Evidence (RWE) Studies

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Supriya Harnal

Product Manager
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Cara Harrington

Marketing Manager
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Steven Hepburn

Director of Business Development
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Jessica Klopp

Project Manager
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Aditya Pai

Director of Business Development
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Sabrina Paradis

Director of Commercial Operations

FileType/PDF Created with Sketch. Genuity_Datasheet_SeqPlus.pdf

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FileType/PDF Created with Sketch. Genuity_Datasheet_TSO500.pdf

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FileType/PDF Created with Sketch. Genuity_Datasheet_WES.pdf

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FileType/PDF Created with Sketch. Genuity_Datasheet_WGS.pdf

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