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World Fusion US, Inc.

San Diego, California, US

World Fusion is a well-established (since 1996) bioinformatics and cheminformatics software developer and services supplier with offices in Japan and the US. We have been at the forefront of developing genomic and drug discovery research tools since our early work on the Human Genome Project, and offer unparalleled reliability and expertise in our services.

Our customizable services include NGS data analysis, in-silico research services, and we are annotation specialists offering the most comprehensive correlations between genes, proteins, diseases, and chemicals.

The majority of the information is generated from our proprietary genomic and drug discovery research platform and knowledge base that we have been upgrading and building upon for over 10 years. It is comprised of original in-house data, curated information from over 60 top public data sets, and a chemical dictionary containing over 75 million... Show more »

World Fusion is a well-established (since 1996) bioinformatics and cheminformatics software developer and services supplier with offices in Japan and the US. We have been at the forefront of developing genomic and drug discovery research tools since our early work on the Human Genome Project, and offer unparalleled reliability and expertise in our services.

Our customizable services include NGS data analysis, in-silico research services, and we are annotation specialists offering the most comprehensive correlations between genes, proteins, diseases, and chemicals.

The majority of the information is generated from our proprietary genomic and drug discovery research platform and knowledge base that we have been upgrading and building upon for over 10 years. It is comprised of original in-house data, curated information from over 60 top public data sets, and a chemical dictionary containing over 75 million non-redundant chemical compounds.

Our more recently added metagenomic and metaranscriptomic analysis services are carried out using state-of-the-art, original in-house software applications.

We offer MANY additional services, please contact us about your specific needs.

NGS Data Analysis:
Variant Analysis
Expression Data Analysis
Metagenome Analysis
Metatranscriptome Analysis

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DNA Sequencing Data Analysis
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Virtual Screening
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We have a chemical dictionary that contains over 75 million non-redundant chemical compounds, with a wealth of knowledge related to each compound, and a highly knowledgeable and experienced chemist on staff. We offer a wide range of in-silico drug discovery services, including target prediction, validation, and confirmation,... Show more »

We have a chemical dictionary that contains over 75 million non-redundant chemical compounds, with a wealth of knowledge related to each compound, and a highly knowledgeable and experienced chemist on staff. We offer a wide range of in-silico drug discovery services, including target prediction, validation, and confirmation, mechanism of action of hit compound, functions of membrane transporter proteins, much more, please inquire about your needs.
•Target prediction from chemical structure using predicted affinity as a score
•Target prioritization from a list of genes, proteins, gene expression/SNV data
•Target discovery from disease name
•Assay-based chemical interactions from genes/proteins
•Pharmacological actions to estimate gene/protein functions

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Chemoinformatics
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Target and Drug Discovery Services:
In-silico target exploration from disease - therapeutic targets, related drugs, gene and protein targets, etc. Includes an extensive annotation table with information about the disease and related diseases, SNPs, compounds, drugs, genes, proteins, and tissues.

Target prediction from chemical... Show more »

Target and Drug Discovery Services:
In-silico target exploration from disease - therapeutic targets, related drugs, gene and protein targets, etc. Includes an extensive annotation table with information about the disease and related diseases, SNPs, compounds, drugs, genes, proteins, and tissues.

Target prediction from chemical structure using predicted affinity- prediction of target proteins which is based on: 1.5M compounds, 5500 proteins, and 5M interactions.

Target Prioritization helps with the selection of gene/proteins for your research, from gene expression/SNV data - the analysis provides information about compounds and the activities, assays, SNPs, diseases, domains, pathways, and references.

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Multiplex Gene Expression Analysis
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Expression data analysis includes over 20 kinds of annotation such as: genes (ontology, pathways), proteins, diseases, domains, ligands, and compounds. Prioritization of genes and proteins can be executed from a variety of directions.
•Statistical processing from expression values
•Conversion and active compound information from... Show more »

Expression data analysis includes over 20 kinds of annotation such as: genes (ontology, pathways), proteins, diseases, domains, ligands, and compounds. Prioritization of genes and proteins can be executed from a variety of directions.
•Statistical processing from expression values
•Conversion and active compound information from proteins
•Inhibitor compounds and inhibitory active compounds
•Assay summary of the target listed by endpoint, such as Ki/IC50
•Positive control chemicals

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Genetic Variant Analysis
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Analysis focuses on the SNP variant amino acid change and includes annotations of related diseases, genes, proteins, assays, ligands, SNPs, domains, and chemical compounds (active compound information, crystal structure, chemical formula, activities, etc.).

•Non-synonomous SNPs and chemicals influenced by mutation... Show more »

Analysis focuses on the SNP variant amino acid change and includes annotations of related diseases, genes, proteins, assays, ligands, SNPs, domains, and chemical compounds (active compound information, crystal structure, chemical formula, activities, etc.).

•Non-synonomous SNPs and chemicals influenced by mutation location
•Information about the compounds and proteins affected by the amino acid change
•Compounds within 6Å likely affected by the amino acid mutations
•SNPs and SNPs related to the disease

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Gene Annotation
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  • Identify relationships beween genes and proteins or diseases
  • Cite connections between genes or proteins and chemicals
  • Extract bind/inhibit chemicals from proteins or genes
  • Examine SNP information and association with disease
  • Find bind/inhibit compounds and therapeutic targets from associated disease
  • Gene... Show more »
  • Identify relationships beween genes and proteins or diseases
  • Cite connections between genes or proteins and chemicals
  • Extract bind/inhibit chemicals from proteins or genes
  • Examine SNP information and association with disease
  • Find bind/inhibit compounds and therapeutic targets from associated disease
  • Gene expression prioritization from RNAseq data
  • Search known functions of miRNA and extract genes and related diseases
  • Identify chemical compounds associated with gene & amino acid mutations
  • Predict target proteins and activity values by mining similarities between protein and chemical structures
  • Examine pathways associated with significant genes and proteins
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Metagenomics Data Analysis
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High throughput sequencing data analysis of 16S/28S/ITS rRNA. Measurement of the composition and diversity of microbial or fungal species in natural environments from NGS data.

Metagenomic analysis of bacteria from species classification of taxonomic rank
Fungal metagenomics analysis can be performed from RDP Classifier... Show more »

High throughput sequencing data analysis of 16S/28S/ITS rRNA. Measurement of the composition and diversity of microbial or fungal species in natural environments from NGS data.

Metagenomic analysis of bacteria from species classification of taxonomic rank
Fungal metagenomics analysis can be performed from RDP Classifier results with ITS 1/2 array seq data from species or, 16S from genus
Taxonomic classification tables with read counts
Interactive sunburst chart
Summarized microbial diversity with pie charts and bar graphs for each rank
Clustering analysis - SOM, PCA and hierarchical clustering
Heat maps
Multiple Sample Analysis
Interactive HTML report of analysis results

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NGS data analysis
Next generation sequencing data analysis
Price on request

•Variant Analysis
•Expression Analysis
•16S/28S/ITS Metagenomic Data Analysis
•Metatranscriptomic Data Analysis

•Variant Analysis
•Expression Analysis
•16S/28S/ITS Metagenomic Data Analysis
•Metatranscriptomic Data Analysis

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Bioinformatics
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Analysis and annotation services.

Analysis and annotation services.

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Metatranscriptomics
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Analysis of the transcripts present in the RNA-seq data through frequency analysis of functional categories from the selected protein DB (such as COG). Result files include annotations from ligand information with related chemical compounds, pathways, and iPath.

•Biological function information
•Metabolic compound info from... Show more »

Analysis of the transcripts present in the RNA-seq data through frequency analysis of functional categories from the selected protein DB (such as COG). Result files include annotations from ligand information with related chemical compounds, pathways, and iPath.

•Biological function information
•Metabolic compound info from proteins
•Multiple sample analysis
•Bar charts, pie charts, and frequency tables

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DNA Sequencing
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Data Services
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Clinical Research
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Computational Modeling
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Biology
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Biostatistics & Bioinformatics
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Sequencing Data Analysis
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Nucleic Acid Analysis
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Nucleic Acid Data Analysis
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Next Generation Sequencing (NGS)
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Metagenomics
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Clinical Molecular Diagnostics
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Clinical Laboratory Services
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DNA
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RNA
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Drug Discovery & Development
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Biochemistry & Molecular Biology
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Drug Discovery
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Nucleic Acid Services
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Genetic Marker Screening Services
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