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Woodland Biosciences

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Worcester, Massachusetts, US

About Woodland Biosciences

Woodland Biosciences is a preclinical contract research organization (CRO) on the campus of Tufts Veterinary Medicine School in North Grafton, MA offering in vivo, preclinical, efficacy modeling services for oncology & metabolic diseases in an AAALAC-accredited facility. We offer xenografts in select solid... Show more »

Woodland Biosciences is a preclinical contract research organization (CRO) on the campus of Tufts Veterinary Medicine School in North Grafton, MA offering in vivo, preclinical, efficacy modeling services for oncology & metabolic diseases in an AAALAC-accredited facility. We offer xenografts in select solid tumors, and the "STZ/HFD" NASH model in both male and female as well as CCl4 and TAA fibrosis and can customize protocols to your needs. Orthotopic and syngeneic models available with a focus on liver and pancreatic cancers. We have many partners rounding out a full discovery and preclinical offering.

Recent Publications

  • Jennifer Johnson, Maria Libera Ascierto, Sandeep Mittal, David Newsome, Liang Kang, Michael Briggs, Kirk Tanner, Francesco M. Marincola, Michael E. Berens, George F. Vande Woude, and Qian Xie, Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma. Journal of Translational Medicine 2015 13:306
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Diversity Certificates

Small business

Our Services (42)


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NAFLD/NASH Mouse Model

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Liver Disease Animal Models

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Liver Fibrosis Animal Models

Price on request

NASH (Non-Alcoholic Steatohepatitis)

STZ + HFD induced. Moderate fibrosis in males. Extra chemical hit provides robust scores in females.

Carbon tetrachloride-induced liver fibrosis in mouse - CCl4 model

Thioacetamide-induced liver fibrosis in mouse or rats - TAA model

The standard readouts of liver fibrosis,... Show more »

NASH (Non-Alcoholic Steatohepatitis)

STZ + HFD induced. Moderate fibrosis in males. Extra chemical hit provides robust scores in females.

Carbon tetrachloride-induced liver fibrosis in mouse - CCl4 model

Thioacetamide-induced liver fibrosis in mouse or rats - TAA model

The standard readouts of liver fibrosis, ballooning degeneration, inflammation assessment and steatosis are routine. We can also run the more extended, high fat diet only model for liver fibrosis (Amylin model) and routinely do DIO (Diet-Induced Obesity) studies for anti-obesity and diabetic drug efficacy.

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Mouse Non-Alcoholic Steatohepatitis (NASH)

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In vivo PK/PD Studies

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Animal Tissue Procurement

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Colon Xenograft

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Colo-205
HT-29 (HTB-38)
HCT-116
C2BBe1(CACO-2)
CACO-2
SW-403
SW-1417
WiDr
SW-48
SW-480
LS-180
LS-174T
Colo-320DM
Colo-320HSR
DLD-1
HCT-15
SW-620
LoVo
Colo-201
SW-948
NCI-H747
NCI-H508
SW-837
SK-CO-1
SW-1116
RKO
GP2d
SNU-C2A
HCT-8
GP5d
T84
LS-411N

Colo-205
HT-29 (HTB-38)
HCT-116
C2BBe1(CACO-2)
CACO-2
SW-403
SW-1417
WiDr
SW-48
SW-480
LS-180
LS-174T
Colo-320DM
Colo-320HSR
DLD-1
HCT-15
SW-620
LoVo
Colo-201
SW-948
NCI-H747
NCI-H508
SW-837
SK-CO-1
SW-1116
RKO
GP2d
SNU-C2A
HCT-8
GP5d
T84
LS-411N

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Brain Tumor Models

Price on request

UCH-1
UCH-2
SH-SY5Y
CCF-STTG1
HTB-14 = U-87 MG
U-118
U-138
U-251MG
LN-18
A-172
LN-229
T98G
M059J
M059K

UCH-1
UCH-2
SH-SY5Y
CCF-STTG1
HTB-14 = U-87 MG
U-118
U-138
U-251MG
LN-18
A-172
LN-229
T98G
M059J
M059K

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Obesity Animal Models

Price on request

The diet-induced obesity model (DIO) is a rapid and efficient means to screen drugs for effects on weight loss.

The diet-induced obesity model (DIO) is a rapid and efficient means to screen drugs for effects on weight loss.

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Animal Food Intake Monitoring

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Diabetes Animal Models

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IPGTT or OGTT analysis in normal, fat or diabetic mouse and rat models are available.

IPGTT or OGTT analysis in normal, fat or diabetic mouse and rat models are available.

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Animal Model in vivo Analyses

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Custom Oncology Animal Models

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In vitro Oncology Models

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Human Tumor Xenograft Models

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Pancreas Patient Derived Xenograft (PDX)

Price on request

UNKC-6141 Syngeneic C57Bl/6 - IO model
L3.6pl
CAPAN-1
MiaPaCa-2
PANC-1
BxPC-3
CRL-1997 / HPAF-II
PL-45
PANC-10.05
AsPC-1
HPAC
PA-TU-8988S
PA-TU-8988T
PA-TU-8902

UNKC-6141 Syngeneic C57Bl/6 - IO model
L3.6pl
CAPAN-1
MiaPaCa-2
PANC-1
BxPC-3
CRL-1997 / HPAF-II
PL-45
PANC-10.05
AsPC-1
HPAC
PA-TU-8988S
PA-TU-8988T
PA-TU-8902

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Liver Cancer Patient Derived Xenograft (PDX)

Price on request

Liver Cancer (HCC) Xenografts - Orthotropic and Flank

MHCC-97H - Highly metastatic to lung
MHCC-97L
MHCC-97L-M6
SNU-398
SNU-449
SNU-182
SNU-475
SNU-387
SNU-423
Hep-3B
HEP-G2
HTB-52 / SK-HEP-1
CRL-11997 / HEP-G2/2.2.1
CRL-11233 / THLE-3
CRL-10741 / C3A
NeHepLxHT
BEL 7402
LS-11
SMMC 7721

Liver Cancer (HCC) Xenografts - Orthotropic and Flank

MHCC-97H - Highly metastatic to lung
MHCC-97L
MHCC-97L-M6
SNU-398
SNU-449
SNU-182
SNU-475
SNU-387
SNU-423
Hep-3B
HEP-G2
HTB-52 / SK-HEP-1
CRL-11997 / HEP-G2/2.2.1
CRL-11233 / THLE-3
CRL-10741 / C3A
NeHepLxHT
BEL 7402
LS-11
SMMC 7721

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Metabolic Animal Models

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Oncology Animal Models

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Animal Models and Studies

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Hepatic Animal Models

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Patient-Derived Xenograft (PDX)

Price on request

Woodland has a number of human liver cancer (HCC predominantly) tumors banked. In addition, we have started to collect pancreatic cancer tumors and have a few growing. We have one patient GBM that has been successfully used in vitro.

Woodland has a number of human liver cancer (HCC predominantly) tumors banked. In addition, we have started to collect pancreatic cancer tumors and have a few growing. We have one patient GBM that has been successfully used in vitro.

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Cell Line Derived Xenograft (CDX) Models

Cell Line Derived Xenograft Models
Price on request

We have a number of human cell lines (>400 AVAILABLE) not all are capable of forming tumors in animals, but inquire if you are interested in a specific line. In addition, we have 6 syngeneic (mouse tumors in immune-competent mice) - see our website for more details.

We have a number of human cell lines (>400 AVAILABLE) not all are capable of forming tumors in animals, but inquire if you are interested in a specific line. In addition, we have 6 syngeneic (mouse tumors in immune-competent mice) - see our website for more details.

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Animal Biospecimens

Price on request

Woodland has experience in timed necropsies with up to 31 different tissues / organs removed and stored properly for histology, RNA or protein analyses. These can be done timed to match drug administration with precision. For the 31 tissues, we were able to have a whole team capable of doing this within 20 minutes per animal,... Show more »

Woodland has experience in timed necropsies with up to 31 different tissues / organs removed and stored properly for histology, RNA or protein analyses. These can be done timed to match drug administration with precision. For the 31 tissues, we were able to have a whole team capable of doing this within 20 minutes per animal, staged necropsy so that organs like liver were taken first to maximize integrity of the samples.

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Animal Models of Disease

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Animal Physiology Analyses

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In vitro Disease Models

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Carcinogenesis Animal Models

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Animal Surgery

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Animal Tumor Volume Measurement

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Project Management

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Cell-Based Assays

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Cell Lines

Price on request

See our cancer modeling for a fairly comprehensive list of cell lines we use for CDX modeling. Many have growth curves.

See our cancer modeling for a fairly comprehensive list of cell lines we use for CDX modeling. Many have growth curves.

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Compound Profiling

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Drug Discovery & Development

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Drug Discovery & Development Services

Drug Discovery & Development Services

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Drug Discovery

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Drug Discovery Services

Drug Discovery Services

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Lead Identification and Validation

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Lead Identification and Validation Services

Lead Identification and Validation Services

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Xenograft Models

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Xenograft Models Services

Xenograft Models Services

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Model Organisms

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Model Organisms Services

Model Organisms Services

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Mammalian Models

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Mammalian Models Services

Mammalian Models Services

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Rodent Models

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Rodent Models Services

Rodent Models Services

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Mouse Models

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Mouse Models Services

Mouse Models Services

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