Woodland Biosciences is a preclinical contract research organization (CRO). Originally located on the campus of Tufts Veterinary Medicine School in North Grafton, MA, in 2020 we joined Ichor Therapeutics in LaFayette, NY to increase capacity, capabilities and to remain an essential business to stay open for our clients and partners. We deliver and develop human disease relevant in vivo, preclinical, and efficacy modeling services for oncology & metabolic diseases in an AAALAC-accredited facility. We offer xenografts in select solid tumors, and the "STZ/HFD" NASH model in both male and female as well as CCl4 and TAA fibrosis and can customize protocols to your needs. Orthotopic and syngeneic models available with a focus on liver and pancreatic cancers. We have many partners rounding out a full discovery and preclinical offering.
NASH (Non-Alcoholic Steatohepatitis)
STZ + HFD induced. Moderate fibrosis in males. Extra chemical hit provides robust scores in females.
Carbon tetrachloride-induced liver fibrosis in mouse - CCl4 model
Thioacetamide-induced liver fibrosis in mouse or rats - TAA model
The standard readouts of liver fibrosis, ballooning degeneration, inflammation assessment and steatosis are routine. We can also run the more extended, high fat diet only model for liver fibrosis (Amylin model) and routinely do DIO (Diet-Induced Obesity) studies for anti-obesity and diabetic drug efficacy.
HTB-14 = U-87 MG
The diet-induced obesity model (DIO) is a rapid and efficient means to screen drugs for effects on weight loss.
IPGTT or OGTT analysis in normal, fat or diabetic mouse and rat models are available.
UNKC-6141 Syngeneic C57Bl/6 - IO model
CRL-1997 / HPAF-II
Liver Cancer (HCC) Xenografts - Orthotropic and Flank
MHCC-97H - Highly metastatic to lung
HTB-52 / SK-HEP-1
CRL-11997 / HEP-G2/2.2.1
CRL-11233 / THLE-3
CRL-10741 / C3A
Woodland has a number of human liver cancer (HCC predominantly) tumors banked. In addition, we have started to collect pancreatic cancer tumors and have a few growing. We have one patient GBM that has been successfully used in vitro.
We have a number of human cell lines (>400 AVAILABLE) not all are capable of forming tumors in animals, but inquire if you are interested in a specific line. In addition, we have 6 syngeneic (mouse tumors in immune-competent mice) - see our website for more details.
Woodland has experience in timed necropsies with up to 31 different tissues / organs removed and stored properly for histology, RNA or protein analyses. These can be done timed to match drug administration with precision. For the 31 tissues, we were able to have a whole team capable of doing this within 20 minutes per animal, staged necropsy so that organs like liver were taken first to maximize integrity of the samples.
See our cancer modeling for a fairly comprehensive list of cell lines we use for CDX modeling. Many have growth curves.
Lead Identification and Validation Services
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