It is crucial to match the pharmacological effects of a new drug to the target cells in a tissue, however this is seldom accomplished at a cellular level. To assess the true effects of a drug is of particular importance if the target cells are underrepresented in an organ/tumor to be analysed. Vivomicx is able... Show more »
It is crucial to match the pharmacological effects of a new drug to the target cells in a tissue, however this is seldom accomplished at a cellular level. To assess the true effects of a drug is of particular importance if the target cells are underrepresented in an organ/tumor to be analysed. Vivomicx is able to tell you what the effects of a (new) drug are on the gene expression profiles of subsets of cells in the organ where the disease is located. These subset cells may either be the target cells for desired effects of the drug or the non-target cells to study bystander effects of undesired toxicity, thus better supporting your compounds go-no-go decisions.
Selected Publications
Example 1: you identified molecules that are overexpressed in your cell culture systems when exposed to disease stimuli.
We can determine in animal tissue and in patient tissues their expression levels in cell types of interest. Within a restricted time frame you will know whether your target is a target with clinical... Show more »
Example 1: you identified molecules that are overexpressed in your cell culture systems when exposed to disease stimuli.
We can determine in animal tissue and in patient tissues their expression levels in cell types of interest. Within a restricted time frame you will know whether your target is a target with clinical opportunities that justifies follow up.
Example 2: you identified the existence of a gene that is essential for the efficacy of your new drug.
We can determine in series of patient biopsies, provided by the customer, the gene expression levels in predestined cells or tissue compartments.
The result is a well defined target for new medicine development.
Drugs in the development pipeline can exert different effects on different cells in complex tissues. If you want to know which cellular response is related to successful intervention that leads to improved disease status, we can provide you with the answer. All you have to do is send us snap-frozen tissue samples from your own... Show more »
Drugs in the development pipeline can exert different effects on different cells in complex tissues. If you want to know which cellular response is related to successful intervention that leads to improved disease status, we can provide you with the answer. All you have to do is send us snap-frozen tissue samples from your own animal models or clinical studies, without the need to exchange information on the nature or identity of the drug.
To allow you to make better drugs faster all we need is pre-clinical or clinical, snap frozen tissues, provided by the customer. In a step-by-step approach, we
To allow you to make better drugs faster all we need is pre-clinical or clinical, snap frozen tissues, provided by the customer. In a step-by-step approach, we
Depending on your interest, we can help you in choosing proper reference genes for the cells under study, and where preferred, genes can be analyse in a blinded fashion
Example 1: you identified molecules that are overexpressed in your cell culture systems when exposed to disease stimuli.
We can determine in animal tissue and in patient tissues their expression levels in cell types of interest. Within a restricted time frame you will know whether your target is a target with clinical... Show more »
Example 1: you identified molecules that are overexpressed in your cell culture systems when exposed to disease stimuli.
We can determine in animal tissue and in patient tissues their expression levels in cell types of interest. Within a restricted time frame you will know whether your target is a target with clinical opportunities that justifies follow up.
Example 2: you identified the existence of a gene that is essential for the efficacy of your new drug.
We can determine in series of patient biopsies, provided by the customer, the gene expression levels in predestined cells or tissue compartments.
The result is a well defined target for new medicine development.
Surrogate biomarkers represent a threat to successful drug development. If you want to know what the effect is of your drug on the diseased cells as a basis for relevant biomarker development, our services can help you out. We determine gene expression profiles in compartments of tissues from healthy, diseased and treated... Show more »
Surrogate biomarkers represent a threat to successful drug development. If you want to know what the effect is of your drug on the diseased cells as a basis for relevant biomarker development, our services can help you out. We determine gene expression profiles in compartments of tissues from healthy, diseased and treated conditions, based on which you can make a rational choice which biomarkers to use for drug efficacy determination.
Vivomicx has not received any reviews.
Vivomicx has not received any endorsements.