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Vivomicx

Groningen, NL

It is crucial to match the pharmacological effects of a new drug to the target cells in a tissue, however this is seldom accomplished at a cellular level. To assess the true effects of a drug is of particular importance if the target cells are underrepresented in an organ/tumor to be analysed. Vivomicx is able to tell you what the effects of a (new) drug are on the gene expression profiles of subsets of cells in the organ where the disease is located. These subset cells may either be the target cells for desired effects of the drug or the non-target cells to study bystander effects of undesired toxicity, thus better supporting your compounds go-no-go decisions.

Selected Publications

  • Langenkamp E, Kamps JA, Mrug M, Verpoorte E, Niyaz Y, Horvatovich P, Bischoff R, Struijker-Boudier H, Molema G (2013). Innovations in studying in vivo cell behaviour and pharmacology in complex tissues - microvascular... Show more »

It is crucial to match the pharmacological effects of a new drug to the target cells in a tissue, however this is seldom accomplished at a cellular level. To assess the true effects of a drug is of particular importance if the target cells are underrepresented in an organ/tumor to be analysed. Vivomicx is able to tell you what the effects of a (new) drug are on the gene expression profiles of subsets of cells in the organ where the disease is located. These subset cells may either be the target cells for desired effects of the drug or the non-target cells to study bystander effects of undesired toxicity, thus better supporting your compounds go-no-go decisions.

Selected Publications

  • Langenkamp E, Kamps JA, Mrug M, Verpoorte E, Niyaz Y, Horvatovich P, Bischoff R, Struijker-Boudier H, Molema G (2013). Innovations in studying in vivo cell behaviour and pharmacology in complex tissues - microvascular endothelial cells in the spotlight. Cell Tissue Res, 354(3):647-69.
  • Dieterich LC, Mellberg S, Langenkamp E, Zhang L, Zieba A, Salomaki H, Teichert M, Huang H, Edqvist PH, Kraus T, Augustin HG, Olofsson T, Larsson E, Soderberg O, Molema G, Ponten F, Georgii-Hemming P, Alafuzoff I, and Dimberg A (2012), Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGF-beta2 in vascular abnormalization. J Pathol, 228 (3):378-390.
  • Langenkamp E, Zwiers PJ, Moorlag HE, Leenders WP, St Croix B, and Molema G (2012). Vascular endothelial growth factor receptor 2 inhibition in-vivo affects tumor vasculature in a tumor type-dependent way and downregulates vascular endothelial growth factor receptor 2 protein without a prominent role for miR-296. Anticancer Drugs; 23: 161-172.
  • Langenkamp E, vom Hagen FM, Zwiers PJ, Moorlag HE, Schouten JP, Hammes HP, Gouw AS, and Molema G (2011), Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged. ISRN Oncology ePub:article ID 409308.
  • Sikkema AH, de Bont ES, Molema G, Dimberg A, Zwiers PJ, Diks SH, Hoving EW, Kamps WA, Peppelenbosch MP, and den Dunnen WF (2011). VEGFR-2 signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells. Neuropathol Appl Neurobiol; 37(5): 538-548.
  • Katta K, Boersema M, Adepu S, Rienstra H, Celie JW, Mencke R, Molema G, van Goor H, Berden JH, Navis G, Hillebrands JL, van den Born J (2013). Renal heparan sulphate proteoglycans modulate fibroblast growth factor 2 signaling in experimental chronic transplant dysfunction. Am J Pathol, 183(5):1571-84.
  • Dickinson MG, Bartelds B, Molema G, Borgdorff MA, Boersma B, Takens J, Weij M, Wichers P, Sietsma H, and Berger RM (2011). Egr-1 expression during neointimal development in flow-associated pulmonary hypertension. Am J Pathol; 179: 2199-2209.
  • van Meurs M, Fisheri NK, Wulfert FM, Asgeirsdottir SA, de Graaf IA, Satchell SC, Mathieson PW, Jongman RM, Kumpers P, Zijlstra JG, Heeringa P, and Molema G (2009). Shock induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function. Am.J Physiol Renal Physiol 297 (2): F272-281.
  • Asgeirsdottir SA, van SC, Kurniati NF, Zwiers PJ, Heeringa P, van MM, Satchell SC, Saleem MA, Mathieson PW, Banas B, Kamps JA, Rabelink TJ, van Zonneveld AJ, and Molema G (2012), MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation. Am J Physiol Renal Physiol; 302(12):F1630-9.
  • Yuan L, Sacharidou A, Stratman AN, Le Bras A, Zwiers PJ, Spokes K, Bhasin M, Shih SC, Nagy JA, Molema G, Aird WC, Davis GE, and Oettgen P (2011). RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG. Blood; 118(4):1145-1153.
  • Asgeirsdottir SA, Kamps JAAM, Bakker HI, Zwiers PJ, Heeringa P, van der Weide K, Van Goor H, Petersen AH, Morselt HW, Moorlag HE, Steenbergen E, Kallenberg CGM, and Molema G (2007), Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium. Mol Pharmacol 72(1): 121-131.
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Drug Target Identification
Price on request

Example 1: you identified molecules that are overexpressed in your cell culture systems when exposed to disease stimuli.

We can determine in animal tissue and in patient tissues their expression levels in cell types of interest. Within a restricted time frame you will know whether your target is a target with clinical... Show more »

Example 1: you identified molecules that are overexpressed in your cell culture systems when exposed to disease stimuli.

We can determine in animal tissue and in patient tissues their expression levels in cell types of interest. Within a restricted time frame you will know whether your target is a target with clinical opportunities that justifies follow up.

Example 2: you identified the existence of a gene that is essential for the efficacy of your new drug.

We can determine in series of patient biopsies, provided by the customer, the gene expression levels in predestined cells or tissue compartments.

The result is a well defined target for new medicine development.

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Biochemical Assays
Price on request

Drugs in the development pipeline can exert different effects on different cells in complex tissues. If you want to know which cellular response is related to successful intervention that leads to improved disease status, we can provide you with the answer. All you have to do is send us snap-frozen tissue samples from your own... Show more »

Drugs in the development pipeline can exert different effects on different cells in complex tissues. If you want to know which cellular response is related to successful intervention that leads to improved disease status, we can provide you with the answer. All you have to do is send us snap-frozen tissue samples from your own animal models or clinical studies, without the need to exchange information on the nature or identity of the drug.

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Drug Discovery
Price on request

To allow you to make better drugs faster all we need is pre-clinical or clinical, snap frozen tissues, provided by the customer. In a step-by-step approach, we

  • check biomolecule integrity in the samples
  • determine the histological quality of the samples
  • analyse gene expression profiles in tissue compartments chosen by... Show more »

To allow you to make better drugs faster all we need is pre-clinical or clinical, snap frozen tissues, provided by the customer. In a step-by-step approach, we

  • check biomolecule integrity in the samples
  • determine the histological quality of the samples
  • analyse gene expression profiles in tissue compartments chosen by the customer.

Depending on your interest, we can help you in choosing proper reference genes for the cells under study, and where preferred, genes can be analyse in a blinded fashion

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Drug Target Validation
Price on request

Example 1: you identified molecules that are overexpressed in your cell culture systems when exposed to disease stimuli.

We can determine in animal tissue and in patient tissues their expression levels in cell types of interest. Within a restricted time frame you will know whether your target is a target with clinical... Show more »

Example 1: you identified molecules that are overexpressed in your cell culture systems when exposed to disease stimuli.

We can determine in animal tissue and in patient tissues their expression levels in cell types of interest. Within a restricted time frame you will know whether your target is a target with clinical opportunities that justifies follow up.

Example 2: you identified the existence of a gene that is essential for the efficacy of your new drug.

We can determine in series of patient biopsies, provided by the customer, the gene expression levels in predestined cells or tissue compartments.

The result is a well defined target for new medicine development.

« Show less
Biomarker Discovery
Price on request

Surrogate biomarkers represent a threat to successful drug development. If you want to know what the effect is of your drug on the diseased cells as a basis for relevant biomarker development, our services can help you out. We determine gene expression profiles in compartments of tissues from healthy, diseased and treated... Show more »

Surrogate biomarkers represent a threat to successful drug development. If you want to know what the effect is of your drug on the diseased cells as a basis for relevant biomarker development, our services can help you out. We determine gene expression profiles in compartments of tissues from healthy, diseased and treated conditions, based on which you can make a rational choice which biomarkers to use for drug efficacy determination.

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Biology
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Lead Identification and Validation
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Pharmacology & Toxicology
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Bioanalysis
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Biomarkers
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Drug Discovery & Development
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Biochemistry & Molecular Biology
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