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VivaCell Biotechnology GmbH

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Denzlingen, DE

About VivaCell Biotechnology GmbH

Type: Public Company

Vivacell Biotechnology GmbH is a privately owned contract-based research organisation (CRO) that provides specialised in vitro and in vivo models for the development and proving the health benefits of cosmetics, oral and personal care products, nutraceuticals, food and bevarages, pharmaceuticals, probiotcials,... Show more »

Vivacell Biotechnology GmbH is a privately owned contract-based research organisation (CRO) that provides specialised in vitro and in vivo models for the development and proving the health benefits of cosmetics, oral and personal care products, nutraceuticals, food and bevarages, pharmaceuticals, probiotcials, natural products, and botanicals.

Additional services for marketing studies are offered.

VivaCell’s preclinical services include standard protocols and protocols adapted to the needs of the customers using a variety of in vitro and in vivo systems.

VivaCell is combining highly qualified cellular and molecular biology knowledge and expertise in various fields.

At VivaCell we offer you complete research projects from basic R&D up to pre-clinical research (GLP) in one hand. Our clients do not have to gather the research data form various CROs.

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Our Services (44)


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In vitro Hair Growth Model

Price on request

We are offering various models to prove the benefits of products (herbal extracts, fractions, compounds etc.) on specific end-points of hair growth and the prevention of hair loss.

• Effects on the proliferation of dermal papilla cells
• Effects on various growth factors in dermal papilla cells (TGF, KGF, IGF, PDGF... Show more »

We are offering various models to prove the benefits of products (herbal extracts, fractions, compounds etc.) on specific end-points of hair growth and the prevention of hair loss.

• Effects on the proliferation of dermal papilla cells
• Effects on various growth factors in dermal papilla cells (TGF, KGF, IGF, PDGF etc.)
• Effects on caspase-3, 7 and 9 in dermal papilla cells
• Effects on cellular energy levels (ATP) in dermal papilla cells/keratinocytes/fibroblasts
• Effects on VEGF expression in keratinocytes
• Effects on TERT
• Effects on 5-alpha reductase I and II
• Effects on Wnt/-catenin pathway
• Effects on inflammation (TNFalpha, IL-1beta, IL-6)
• Effects on human dermal papilla cells/keratinocytes co-cultures/3D culture (all parameters)
• Other parameters on request

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In vitro Disease Models

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In vitro Neurodegeneration Models

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In vitro Angiogenesis Assays

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At VivaCell, we have adapted specific protocols “in vitro” to study the anti-tumoural activity of compounds, extracts etrc.. More than 100 parameters including cellular, molecular and biochemical techniques are offered to our client, and by using such parameters we run projects adapted to each drug and tailored to customer’s... Show more »

At VivaCell, we have adapted specific protocols “in vitro” to study the anti-tumoural activity of compounds, extracts etrc.. More than 100 parameters including cellular, molecular and biochemical techniques are offered to our client, and by using such parameters we run projects adapted to each drug and tailored to customer’s needs.

In vitro testing methods include proliferation inhibition assays using human tumour cell lines, as well as clonogenic assays with human tumor xenografts, human tumor cell lines, and hematopoetic stem cells. More than 350 solid tumor models have been established in serial passage as well as 20 permanent tumor cell lines (co-operation). In addition, a panel of 60 cell lines, commonly used in cancer research such as A549, MCF-7, Caco-2, HT29 or PC3, are also available. Cancer cell lines overexpressing the MDR1 gene are also available for drug research.

In vivo assays include subcutaneous models, orthotopic models with human xenografts, murine tumour models (co-operation) and models of topic co-carcinogenesis inducing papilloma-like skin tumours in athymic mice.

Angiogenesis(e.g. VEGF, angiopoietin I and II, nephrin, i.e.). In vitro3D assays (spheroids), HUVECs and Matrigel Basement Membrane Matrix, In vivocorneal neovascularization assays, 3D assays (spheroids injected s.c.),

Parameters:

  • Proliferation, XTT assays, determination of DNA content by FACS analyses
  • Cytokines (e.g. IL-6), growth factors (e.g. EGF) etc.
  • Cell cycle analyses, cytotoxicity by measuring PI staining
  • Determination of DNA fragmentation (apoptosis) by TUNEL
  • Transmembrane potential of the mitochondria, calcium and pH mobilisation
  • Reactive oxygen species (ROS)
  • Fas clustering and signalling in type I and II cells for apoptosis
  • Caspases (3, 7, 8, 6 and 9) activity by spectrofluorometry and western blots
  • Bcl-2, Bcl-X, Bax, Bid and cytoplasmic cytochrome C by western blots and PCR.
  • Apoptosis and cell cycle analyses in transfected MDR (pgp-1) cell lines
  • Phosphatidyl serine expression at the cell surface by Anexin V binding.
  • Integrity of tubulin and actin by fluorescence microscopy
  • In vitro assays for tubulin polimerization.
  • Cyclin activities by IP and Western blots
  • Activation of Transcription Factors
  • Signalling studies MAPKs, IKK, ie..
  • Determination of Telomerase activity in HeLa cells by Telomerase PCR ELISA
  • Customized “knock out” cell lines for specific genes
  • DNA microarrays for cancer-related genes in tumoural cell lines

Other specific cellular and molecular techniques are available upon request.

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Metabolic Disease Animal Models

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Cosmetic and Personal Care Product Testing

Price on request

Vivacell Biotechnology GmbH provides specialised in vitro models and assays for testing and developing ingredients, formulations, and end products for the cosmetic, dermato-cosmetic, hair, personal and oral care market.

Our major task is to support clients to prove the health benefits of their products in the following... Show more »

Vivacell Biotechnology GmbH provides specialised in vitro models and assays for testing and developing ingredients, formulations, and end products for the cosmetic, dermato-cosmetic, hair, personal and oral care market.

Our major task is to support clients to prove the health benefits of their products in the following topics.

  • Anti-Aging
  • Beauty/Aesthetic
  • Skin Protection
  • Skin Comfort
  • Skin Regeration
  • Immunocosmetic
  • Oral Care
  • Anti-Acne

and many others.

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Compound Profiling

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Histone Deacetylase (HDAC) Assays

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DNA Methylation Analysis

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ELISA

Enzyme-linked immunosorbent assay
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Western Blot

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Immunohistochemistry (IHC)

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qPCR

Quantitative PCR
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Luciferase Assays

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Cell Lines

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Tissue Preparation

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Human Monocytes

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Human Macrophages

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Human T Cells

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Scientific Manuscript Preparation

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DNA Services

Price on request

DNA Services

DNA Services

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Biochemistry & Molecular Biology

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Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

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In vitro Reporter Gene Assays

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In vitro Reporter Gene Assays Services

In vitro Reporter Gene Assays Services

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Cell-Based Assays

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Cell-Based Assays Services

Cell-Based Assays Services

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Tissue Processing

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Tissue Processing Services

Tissue Processing Services

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Human Primary Cells

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Human Primary Cells Services

Human Primary Cells Services

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Cells and Tissues

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Cells and Tissues Services

Cells and Tissues Services

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Biology

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Biology Services

Biology Services

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Editorial and Writing Services

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Editorial and Writing Services

Editorial and Writing Services

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Animal Models of Disease

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Animal Models of Disease Services

Animal Models of Disease Services

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Animal Models and Studies

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Animal Models and Studies Services

Animal Models and Studies Services

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Product Testing Services

Price on request

Product Testing Services

Product Testing Services

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Product Development, Testing, and Packaging

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Product Development, Testing, and Packaging Services

Product Development, Testing, and Packaging Services

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Lead Identification and Validation

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Lead Identification and Validation Services

Lead Identification and Validation Services

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Drug Discovery & Development

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Drug Discovery & Development Services

Drug Discovery & Development Services

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Hydrolase Assays

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Hydrolase Assays Services

Hydrolase Assays Services

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Enzyme Assays

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Enzyme Assays Services

Enzyme Assays Services

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Biochemical Assays

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Biochemical Assays Services

Biochemical Assays Services

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Epigenetic Studies

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Epigenetic Analysis Services

Epigenetic Analysis Services

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Protein Quantification

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Protein Quantification Services

Protein Quantification Services

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Immunostaining

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Immunostaining Services

Immunostaining Services

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Angiogenesis & Endothelial Cell Assays

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Angiogenesis & Endothelial Cell Assays Services

Angiogenesis & Endothelial Cell Assays Services

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Omics

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RT-PCR

Reverse transcription polymerase chain reaction
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