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Visikol Inc

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New Brunswick, New Jersey, US

About Visikol Inc

Visikol is a preclinical contract research organization that is focused on digital pathology, in vitro assays and whole mount tissue imaging. The company has an expertise in advanced 3D cell culture models, high content screening, 3D tissue imaging and quantitative image analysis.

Visikol’s mission is to... Show more »

Visikol is a preclinical contract research organization that is focused on digital pathology, in vitro assays and whole mount tissue imaging. The company has an expertise in advanced 3D cell culture models, high content screening, 3D tissue imaging and quantitative image analysis.

Visikol’s mission is to help clients accelerate their drug discovery efforts through acquiring more complete information from tissues and shifting the paradigm of tissue analysis from qualitative and human-driven to a quantitative data-driven approach.

Digital Pathology

Visikol works closely with pharmaceutical clients to shift their tissue characterization approach from qualitative to quantitative. Visikol has developed a suite of digital pathology tools which are leveraged in our services to develop customized image analysis algorithms for our clients. We help clients with very simple questions such as quantitatively analyzing IHC expression in slides all the way to developing potency assays for submission to the FDA.

To work with us on shifting slide analysis to a digital approach, clients can send us digital image files or can send along physical slides that we can scan and analyze. Our approach with our digital pathology assays and all of the services we offer is to distill terabytes of data down to a simple actionable report.

In Vitro Services

Visikol offers a wide-range of in vitro assays to clients and has a specific focus and expertise in 3D cell culture models. Because of large discrepancies in cost between 3D cell culture models, Visikol works closely with clients to determine the appropriate in vivo relevancy, validation criteria and throughput for a client’s assay. Visikol then leverages its in-house cell culturing capabilities to generate the appropriately scaled model, from simple, single cell type models to highly complex models, depending on the specific research question. Models can in turn be used to study the progression of a physiological or pathophysiological process, stipulated by client and validated in the customized model and/or to interrogate the effects of a client-developed therapeutic candidate on the disease model.

In assessing the model itself and the effects of any interventional approach assayed, Visikol works closely with the client to determine the specific type of data that should be acquired and can run assays employing techniques as simple as plate reading or as complex as high content confocal imaging. Importantly, when it comes to imaging-based endpoint measurements, with the patented Visikol HISTO-M technology, Visikol is the only CRO capable of characterizing the entirety of 3D cell culture models, even cells deep within the cortex of complex, multi-cellular spheroids. This results in more accurate quantitation of cell frequencies, co-localization of targets with various cell subtypes, and distinction of zoned cell subtypes, particularly in the context of more architecturally complex models. This all results in our clients obtaining more accurate results to inform the next stages of their drug discovery and development campaigns.

We see ourselves as an end-to-end provider of 3D cell culture assays and can work with clients in a number of ways. Clients can send us compounds and we can run entire assays all the way to a detailed final report or we can execute single components of a campaign such as model development and validation, imaging of developed and/or treated models, or image processing of client-provided data sets depending on a clients need.

Whole Mount Imaging Services

In addition to quantitative image analysis, Visikol is also focused on answering complex histological questions through 3D tissue imaging. Visikol has developed a patented tissue clearing technique called Visikol HISTO that allows for the rapid 3D visualization of tissues through confocal microscopy and fluorescent labeling. We work with clients on complex questions such as screening compounds for their effects on retina angiogenesis where we use 3D tissue imaging to distill terabytes of 3D retina data into vasculature maps and actionable insights such as the number of branch points and vasculature volume.

We combine our unique 3D tissue labeling, clearing, and imaging platform with our digital pathology tools to help answer a wide range of research questions for our clients and offer the following services in this space:

  • Tissue clearing and fluorescent 3D tissue imaging with confocal or light sheet microscopy
  • 1 mm thick whole mount tissue imaging
  • Antibody labeling optimization
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Our Services (76)


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Microbiome Studies

Price on request

Assessment of Microbial Metabolism of Drug Assay

Many drugs are metabolized via the biliary route and subsequently enter the intestines, where they are exposed to the gut microbiome. In addition, it is common for pills to be incompletely broken down, allowing unaltered parent drug to enter the intestines. Thus, our indigenous... Show more »

Assessment of Microbial Metabolism of Drug Assay

Many drugs are metabolized via the biliary route and subsequently enter the intestines, where they are exposed to the gut microbiome. In addition, it is common for pills to be incompletely broken down, allowing unaltered parent drug to enter the intestines. Thus, our indigenous microbes are exposed to both human metabolites and pure drug compound regularly. These bacteria, archaea, and fungi in the intestines partially metabolize many pharmaceutical compounds, often in very different ways than the human body metabolizes a drug. This process exposes our gut microbes and the host gut epithelial cells not only to the parent drug and human metabolite, but also to any microbial metabolites. The host epithelial cells may reabsorb microbial metabolites, as is the case with Irinotican. In this example patients exposed to the most microbial metabolite develop severe diarrhea. Our assay will qualitatively and quantitatively assess drug turnover by gut microbes, identifying new microbial metabolites of the drug. Further, if the microbial mechanism of drug turnover is known, we can quantitatively analyze interindividual differences in a particular mechanism to identify individuals with the highest rate of turnover.

Assessment of Drug and Metabolite Impact to Microbiome Structure and Function Assay

Many recent academic studies have focused on assessing the toxicity of drugs to the human microbiome. Approaches often include classic microbiology (microbial growth and metabolism), metabolomics, and changes to community structure. We have the capacity to analyze these effects both in pure culture and in complex communities. This type of profiling allows us to address complex questions, such whether a certain subset of the microbial community is particularly sensitive to a given drug.
1) Analysis: expose pure culture or whole community to drug, control non-exposed community
- Pure culture: growth changes
- Whole community: Next-generation sequence analysis

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3D Cell Culture Models

Starting at $150.00 per plate

Visikol has in-house 3D cell culturing capabilities and works with clients to generate models that meet their specific cost, throughput, in-vivo relevancy and validation requirements. Visikol recognizes that 3D cell culture models are not a one-size-fits-all tool and that these models need to be developed specifically for each... Show more »

Visikol has in-house 3D cell culturing capabilities and works with clients to generate models that meet their specific cost, throughput, in-vivo relevancy and validation requirements. Visikol recognizes that 3D cell culture models are not a one-size-fits-all tool and that these models need to be developed specifically for each assay. We partner closely with clients to determine the best type of model for their specific research question and testing requirements. Some assays can utilize inexpensive single cell type spheroids to better replicate the in vivo microenvironment than do 2D cell culture approaches whereas other assays might require highly complex multi-cell-type models.

After we have generated an appropriate model for a client or brought a model in from a 3rd party, we can run full screening campaigns using assays ranging from simple plate reading all the way to high content confocal assays with multi-channel immunolabeling and advanced image processing. We are the only CRO capable of characterizing 3D cell culture models in their entirety through our patented Visikol HISTO-M tissue clearing technology. Our clients consider us the industry leader in 3D cell culture characterization.

To get started with us, reach out and tell us about your research question.

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Thermo Scientific CX-7 CellInsight HCS reader Confocal microscope High content liquid handling Human Rabbit Guinea pig Mouse Rat Nonhuman primates Nile Red monoclonal antibodies DAPI AlexaFluor Polyclonal antibodies Secondary antibodies Live/Dead staining Caspase 3/7 substrate LipidTOX ImageJ Custom image processing and commercial image processing software CellProfiler Immunology Oncology CNS/Neurology Cardiovascular Nephrology and Urology Metabolism and Endocrinology Hepatology Cancer Fibrosis Colorectal cancer Diabetes Breast cancer Non-Alcoholic Steatohepatitis (NASH) Lung Cancer Liver cancer Liver Disease Drug-induced liver injury Cardiac hypertrophy Neurotoxicity High Content Analysis High content imaging Antibodies Primary Cells Stem Cells Biology Drug Discovery Toxicology Neuroscience Show 49 more tags Show less

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3D Cell Culture Model Analytics

Starting at $1,200.00 per plate

Visikol has an expertise in quantitative tissue imaging and executes end-to-end 3D cell culture assays for its clients from model generation to compound/antibody screening, analysis and reporting. Visikol offers simple plate reading analysis all the way to high resolution, high content, multi-channel confocal microscopy for its... Show more »

Visikol has an expertise in quantitative tissue imaging and executes end-to-end 3D cell culture assays for its clients from model generation to compound/antibody screening, analysis and reporting. Visikol offers simple plate reading analysis all the way to high resolution, high content, multi-channel confocal microscopy for its clients. The Visikol team is comprised of experts in image analysis and have developed a suite of digital pathology tools that allow 3D cell culture models to be assessed in any way that a client desires. Additionally, Visikol is the only CRO capable of acquiring all of the data from 3D cell culture models, as its Visikol HISTO-M 3D clearing technique enables complete quantitation of cells throughout the entirety of complex, multi-cellular models, even deep within the 3D model cortex. All other CRO's bias 3D cell culture image based analysis to only the cells on the periphery of models, which can provide highly misleading results.

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Thermo Scientific CX-7 CellInsight HCS reader Confocal microscope High content liquid handling Human Rabbit Guinea pig Mouse Rat Nonhuman primates ImageJ CellProfiler Custom, in-house image processing software Immunology Oncology CNS/Neurology Cardiovascular Metabolism and Endocrinology Hepatology Cancer Fibrosis Diabetes Breast cancer Non-Alcoholic Steatohepatitis (NASH) Lung Cancer Liver cancer Bladder cancer Drug-induced liver injury Cardiac hypertrophy Neurotoxicity High Content Analysis High content imaging Primary Cells Stem Cells Biology Drug Discovery Toxicology Neuroscience Show 37 more tags Show less

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Cytotoxicity Assays

Price on request

Understanding the effects of a test compound on cell health and viability can be a crucial early step in the drug discovery and development process. Visikol's 2D or 3D in vitro cytotoxicity assays offer a high-content/high-throughput format for assessing cytotoxic effects.

Particularly in the assessment of cell... Show more »

Understanding the effects of a test compound on cell health and viability can be a crucial early step in the drug discovery and development process. Visikol's 2D or 3D in vitro cytotoxicity assays offer a high-content/high-throughput format for assessing cytotoxic effects.

Particularly in the assessment of cell subtype-specific cytotoxic effects of compounds in more complex, multicellular models, Visikol exceeds the standard in the field by offering an analysis of cell subtype breakdown of non-viable cells in whole spheroids or tissues when paired with our immunolabeling and clearing services.

Moreover, determining whether cell death is the result of a model flaw, such as the development of a necrotic core in larger, more complex multicellular microtissue models or the true result of test-compound treatment can be crucial to drawing accurate conclusions in drug screening campaigns. Therefore, Visikol offers a quantitative analysis of non-viable cell location within microtissues; Localization to the central core typically indicates necrosis due to lack of adequate nutrient supply in larger models, whereas localization to the outer cell layers or even distribution throughout the model is typically more indicative of test-compound effects. With our proprietary clearing technology, Visikol is the only CRO capable of characterizing all of the cells within 3D models, enabling this service to be performed.

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3D Vasculature Imaging

Starting at $500.00 per sample

Vasculature is a complex three-dimensional feature which is challenging to quantitatively evaluate using traditional two-dimensional histology. Using our patented Visikol HISTO tissue clearing technique combined with fluorescent labeling and 3D imaging (confocal and light sheet microscopy), we are able to visualize vasculature in... Show more »

Vasculature is a complex three-dimensional feature which is challenging to quantitatively evaluate using traditional two-dimensional histology. Using our patented Visikol HISTO tissue clearing technique combined with fluorescent labeling and 3D imaging (confocal and light sheet microscopy), we are able to visualize vasculature in 3D. When analyzed with our digital pathology algorithms, we are then able to transform these 3D vasculature networks into quantitative end-points (volume, branching, etc.) for your studies. This allows researchers to quantitatively address a number of research questions. For example, the impact of a compound or antibody on the process of angiogenesis can be assessed in a reliable, quantitative fashion. We can conduct in-depth vasculature studies on a few tissues at a time in preliminary studies or screens on hundreds of tissues as part of a larger campaign.

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Thermo Scientific CX-7 CellInsight HCS reader Confocal microscope Human Rabbit Guinea pig Mouse Rat Nonhuman primates monoclonal antibodies DAPI Polyclonal antibodies Secondary antibodies ImageJ Cell Profiler Custom image processing and commercial image processing software Regenerative Medicine Oncology CNS/Neurology Cardiovascular Cancer Breast cancer Lung Cancer Gastric Cancer Bladder cancer FFPE tissue Frozen Tissue Human tissue Fresh Tissue Tumor tissue Whole organs Biology Drug Discovery Toxicology Neuroscience Show 34 more tags Show less

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Organoids

Starting at $150.00 per plate

Visikol has in-house 3D cell culturing capabilities and works with clients to generate models that meet their specific cost, throughput, in-vivo relevancy and validation requirements. Visikol recognizes that 3D cell culture models are not a one-size-fits-all tool and that these models need to be developed specifically for each... Show more »

Visikol has in-house 3D cell culturing capabilities and works with clients to generate models that meet their specific cost, throughput, in-vivo relevancy and validation requirements. Visikol recognizes that 3D cell culture models are not a one-size-fits-all tool and that these models need to be developed specifically for each assay. We partner closely with clients to determine the best type of model for their specific research question and testing requirements. Some assays can utilize inexpensive single cell type spheroids to better replicate the in vivo microenvironment than do 2D cell culture approaches, whereas other assays might require highly complex multi-cell-type models.

After we have generated a model for a client or brought a model in from a 3rd party, we can run full screening campaigns using assays ranging from simple plate reading all the way to high content confocal assays with multi-channel immunolabeling and advanced image processing. We are the only CRO capable of characterizing 3D cell culture models in their entirety through our patented Visikol HISTO-M tissue clearing technology. As a result, our clients consider us the industry leader in 3D cell culture characterization.

To get started with us, reach out and tell us about your research question.

Show less
Thermo Scientific CX-7 CellInsight HCS reader Confocal microscope High content liquid handling Human Rabbit Guinea pig Mouse Rat Nonhuman primates Nile Red monoclonal antibodies DAPI AlexaFluor Polyclonal antibodies Secondary antibodies Live/Dead staining Caspase 3/7 substrate LipidTOX ImageJ Cell Profiler Custom, in-house image processing software Immunology Oncology CNS/Neurology Cardiovascular Metabolism and Endocrinology Hepatology Cancer Fibrosis Colorectal cancer Diabetes Prostate Cancer Breast cancer Non-Alcoholic Steatohepatitis (NASH) Lung Cancer Liver cancer Bladder cancer Drug-induced liver injury Cardiac hypertrophy Neurotoxicity High Content Analysis High content imaging Primary Cells Stem Cells Biology Drug Discovery Toxicology Neuroscience Show 48 more tags Show less

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Organotypic Cell Culture

Starting at $150.00 per plate

Visikol has in-house 3D cell culturing capabilities and works with clients to generate models that meet their specific cost, throughput, in-vivo relevancy and validation requirements. Visikol recognizes that 3D cell culture models are not a one-size-fits-all tool and that these models need to be developed specifically for each... Show more »

Visikol has in-house 3D cell culturing capabilities and works with clients to generate models that meet their specific cost, throughput, in-vivo relevancy and validation requirements. Visikol recognizes that 3D cell culture models are not a one-size-fits-all tool and that these models need to be developed specifically for each assay. We partner closely with clients to determine the best type of model for their specific research question and testing requirements. Some assays can utilize inexpensive single cell type spheroids to better replicate the in vivo microenvironment than do 2D cell culture approaches, whereas other assays might require highly complex multi-cell-type models.

After we have generated a model for a client or brought a model in from a 3rd party, we can run full screening campaigns using assays ranging from simple plate reading all the way to high content confocal assays with multi-channel immunolabeling and advanced image processing. We are the only CRO capable of characterizing 3D cell culture models in their entirety through our patented Visikol HISTO-M tissue clearing technology. As a result, our clients consider us the industry leader in 3D cell culture characterization.

To get started with us, reach out and tell us about your research question.

Show less
Thermo Scientific CX-7 CellInsight HCS reader Confocal microscope High content liquid handling Human Rabbit Guinea pig Mouse Rat Nonhuman primates Nile Red monoclonal antibodies DAPI AlexaFluor Polyclonal antibodies Secondary antibodies Live/Dead staining Caspase 3/7 substrate LipidTOX ImageJ Cell Profiler Custom image processing and commercial image processing software Immunology Oncology CNS/Neurology Cardiovascular Metabolism and Endocrinology Hepatology Cancer Fibrosis Colorectal cancer Diabetes Breast cancer Non-Alcoholic Steatohepatitis (NASH) Lung Cancer Epilepsy Liver cancer Drug-induced liver injury Cholestasis Cardiac hypertrophy Neurotoxicity High Content Analysis High content imaging Primary Cells Stem Cells Biology Drug Discovery Toxicology Neuroscience Show 48 more tags Show less

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Confocal Microscopy

Starting at $220.00 per sample

We offer fee-for-service 3D tissue labeling and imaging. Our standard service consists of 1 mm tissue section labeling and imaging where clients send us a tissue and we send back a digital stack of optical Z-sections from your tissue.

Our standard service is comprised of:
- 10X magnification imaging with 10 um Z steps.
-... Show more »

We offer fee-for-service 3D tissue labeling and imaging. Our standard service consists of 1 mm tissue section labeling and imaging where clients send us a tissue and we send back a digital stack of optical Z-sections from your tissue.

Our standard service is comprised of:
- 10X magnification imaging with 10 um Z steps.
- Nuclear label plus one antibody label (from list of Visikol HISTO validated antibodies).
- USB stick shipped back to customer
- Two week turnaround time

We can also conduct up to four channel imaging and can optimize antibody labeling for new antibodies.

Also, please see our image analysis services to add quantitative insights to any confocal microscopy services.

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Thermo Scientific CX-7 CellInsight HCS reader Confocal microscope Human Rabbit Guinea pig Mouse Rat Dog Nonhuman primates monoclonal antibodies DAPI AlexaFluor Polyclonal antibodies Secondary antibodies ImageJ Custom image processing and commercial image processing software CellProfiler Immunology Oncology CNS/Neurology Cardiovascular Metabolism and Endocrinology Hepatology Cancer Melanoma Fibrosis Colorectal cancer Diabetes Prostate Cancer Breast cancer Alzheimers Disease Ovarian Cancer Traumatic brain injury (TBI) Pancreatic cancer Liver cancer Bladder cancer Fluorescent labeling Immunofluorescence Fluorescent insitu hybridization Optical Imaging 3D imaging FFPE tissue Frozen Tissue Human tissue Fresh Tissue Tumor tissue Whole organs Biology Drug Discovery Toxicology Neuroscience Show 51 more tags Show less

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Digital Pathology Image Analysis

Starting at $20.00 per slide

At Visikol our core focus is on advanced optical imaging and digital image analysis to provide researchers with quantitative and actionable insights as a service. We have developed a portfolio of digital pathology tools that we use to help you transition from qualitative to quantitative histopathology analysis. Typically, clients... Show more »

At Visikol our core focus is on advanced optical imaging and digital image analysis to provide researchers with quantitative and actionable insights as a service. We have developed a portfolio of digital pathology tools that we use to help you transition from qualitative to quantitative histopathology analysis. Typically, clients will send us tissues, slides or just digital files and we will work with the client to answer a specific research question such as developing a quantitative quality control assay or quantifying the specific phenotypic effect of a drug compound. We offer a full spectrum of digital pathology solutions including:

  • Customizable feature extraction for morphology of interest
  • Automated feature quantification from digital pathology slides using 3Screen software.
  • Reproducible and accurate quantitative data for developing quality control assays, understanding dose response effects, and addressing complex biological questions.
  • Suite of algorithms that include: co-localization, area analysis, H-score, biomarker analysis, intensity thresholding and structure differentation.
  • Generation of multi-dimensional data outputs that can be processed using 3Screen clustering analysis.

Through our suite of digital pathology tools we can extract thousands of features (e.g. nuclei size, distribution etc) from slides instantaneously. This means that complex questions and quantitative assays (e.g. transplant quality control) can be developed in circumstances where a traditional qualitative approach would be limited. The shift to quantitative histology means that quantitative fingerprints can be identified facilitating ranking and comparison across hundreds of dimensions (e.g. necrosis, cell death) in the context of our clients' drug discovery and pre-clinical efforts.

We also understand that the jump to digital pathology can be big one for many research groups that have relied on traditional histopathology. Therefore, we typically begin all of our service projects with short, inexpensive pilot studies, so our clients can quickly see how digital pathology fits into their research workflows.

How our services work:

1) Define your research question, morphological features and desired end-points.
2) Send Visikol slides for slide scanning or digital renderings of slides.
3) Visikol extracts key features from digital renderings and analyzes based upon research question.
4) Visikol returns quantitative analysis report back to the customer.

Please reach out to us about your research needs

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Tissue Clearing

Starting at $500.00 per sample

At Visikol our main focus is on transforming tissues into three-dimensional data sets that can be analyzed for actionable insights. We have developed a suite of Visikol HISTO tissue clearing reagents that we sell to researchers as well as use within our portfolio of imaging and image analysis assays. We have developed our Visikol... Show more »

At Visikol our main focus is on transforming tissues into three-dimensional data sets that can be analyzed for actionable insights. We have developed a suite of Visikol HISTO tissue clearing reagents that we sell to researchers as well as use within our portfolio of imaging and image analysis assays. We have developed our Visikol HISTO-1 and Visikol HISTO-2 reagents for use with whole tissues (e.g. mouse brains) and to be compatible with immunolabeling and fluorescent protein. Additionally, we have developed our Visikol HISTO-M tissue clearing reagent to be compatible with 3D cell culture models (e.g. organoids, spheroids, microtissues) and high-throughput process. The Visikol HISTO reagents are also reversible which means that 3D imaging can be followed up with traditional histopathological analysis.

If you are interested in using tissue clearing in your lab you can purchase our Visikol HISTO tissue clearing reagents or send us tissues to label, clear, image and analyze. Our Visikol HISTO Starter Kits start at $489.99 and our services start at $499.99 per sample.

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High Content Screening

Price on request

We currently offer a suite of best-in-class 2D and 3D in vitro high content screening assays and are the only CRO capable of complete 3D cell culture characterization through the use of our patented tissue clearing technology. We work closely with our clients to determine the optimal model, data output and analysis for each... Show more »

We currently offer a suite of best-in-class 2D and 3D in vitro high content screening assays and are the only CRO capable of complete 3D cell culture characterization through the use of our patented tissue clearing technology. We work closely with our clients to determine the optimal model, data output and analysis for each individual research question while balancing throughput, cost and in vivo relevancy. Our capabilities stretch the full spectrum of data density and throughput from high throughput 2D cell culture based dissolution assays to high resolution 3D organoid confocal imaging and digital image analysis.

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Thermo Scientific CX-7 CellInsight HCS reader Confocal microscope High content liquid handling Human Rabbit Guinea pig Mouse Rat Nonhuman primates Nile Red monoclonal antibodies DAPI AlexaFluor Polyclonal antibodies Secondary antibodies Live/Dead staining Caspase 3/7 substrate LipidTOX ImageJ Cell Profiler Custom image processing and commercial image processing software Immunology Oncology CNS/Neurology Cardiovascular Metabolism and Endocrinology Hepatology Cancer Fibrosis Colorectal cancer Diabetes Prostate Cancer Breast cancer Non-Alcoholic Steatohepatitis (NASH) Lung Cancer Liver cancer Drug-induced liver injury Cardiac hypertrophy Neurotoxicity Hepatotoxicity High Content Analysis High content imaging Antibodies Primary Cells Stem Cells Monoclonal antibodies Biology Drug Discovery Toxicology Neuroscience Show 50 more tags Show less

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3D Immunostaining

Starting at $500.00 per sample

Visikol has optimized its Visikol HISTO tissue clearing and immunolabeling approach for uniform whole tissue labeling and 3D imaging. We offer 3D tissue labeling and imaging services using our suite of 3D optimized immunolabels and advanced 3D microscopy.

We offer 3D tissue labeling and imaging services for as little as $500... Show more »

Visikol has optimized its Visikol HISTO tissue clearing and immunolabeling approach for uniform whole tissue labeling and 3D imaging. We offer 3D tissue labeling and imaging services using our suite of 3D optimized immunolabels and advanced 3D microscopy.

We offer 3D tissue labeling and imaging services for as little as $500 per 1 mm tissue sample where the tissue sample is transformed into 1,800 images (2 channels). The data from tissues is sent back to a client within two weeks upon receipt of the tissue.

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Whole Slide Imaging/Digital Slide Scanning

Price on request

At Visikol we offer a full suite of digital pathology solutions from slide scanning to developing customized digital pathology solutions for clients. For slide scanning we currently offer:

  • Whole slide imaging
  • High resolution images up to 40x preserved digitally
  • H&E, IHC, and fluorescent stains
  • Images are compatible... Show more »

At Visikol we offer a full suite of digital pathology solutions from slide scanning to developing customized digital pathology solutions for clients. For slide scanning we currently offer:

  • Whole slide imaging
  • High resolution images up to 40x preserved digitally
  • H&E, IHC, and fluorescent stains
  • Images are compatible with most image-analysis systems
  • Raw images can be returned via hard drive or viewed online
  • Secure and simple access to files
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Aperio Human Rabbit Mouse Rat Custom image processing and commercial image processing software IHC H&E staining whole slide imaging FFPE tissue Show 10 more tags Show less

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Light Sheet Microscopy

Starting at $500.00 per sample

We have offer fee-for-service 3D tissue labeling and imaging. Our standard service consists of 1 mm tissue section labeling and imaging where you send us a tissue and we send back a digital stack of optical Z-sections from your tissue.

Our standard service is comprised of:
- 10X magnification imaging with 10 um Z steps.
-... Show more »

We have offer fee-for-service 3D tissue labeling and imaging. Our standard service consists of 1 mm tissue section labeling and imaging where you send us a tissue and we send back a digital stack of optical Z-sections from your tissue.

Our standard service is comprised of:
- 10X magnification imaging with 10 um Z steps.
- Nuclear label plus one antibody label (from list of Visikol HISTO validated antibodies).
- USB stick shipped back to customer
- Two week turnaround time

We can also conduct up to four channel imaging and can optimize antibody labeling for new antibodies.

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Human Rabbit Mouse Rat Nonhuman primates Custom image processing and commercial image processing software Fluorescent labeling Immunofluorescence FFPE tissue Frozen Tissue Human tissue Fresh Tissue Show 12 more tags Show less

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3D Cell-Based Assays

Price on request

Visikol leverages its Visikol HISTO-M tissue clearing technology combined with high content confocal imaging and advanced 3D cell culture models to offer best-in-class 3D cell culture assays. We work closely with clients to determine the specific type of model and end-points required to address their specific research question. We... Show more »

Visikol leverages its Visikol HISTO-M tissue clearing technology combined with high content confocal imaging and advanced 3D cell culture models to offer best-in-class 3D cell culture assays. We work closely with clients to determine the specific type of model and end-points required to address their specific research question. We offered standardized assays for the following applications as well as customized assays.

Antibody Penetration
Apoptosis
Angiogenesis
Cell-cell Junctions and Cadherins
Cell Proliferation
Cell Migration
Cell Viability
Cholestasis
Steatosis
Drug Induced Liver Injury
Fibrosis
Immune Cell Invasion
Inflammatory Signaling
Mitochondrial Health + Toxicity
NASH
ROS

All you need to do is send us plates of compounds or antibodies and we can send back insights.

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Thermo Scientific CX-7 CellInsight HCS reader Confocal microscope Human Mouse Rat Custom image processing and commercial image processing software Cancer Fibrosis Colorectal cancer Breast cancer Non-Alcoholic Steatohepatitis (NASH) Lung Cancer Liver cancer Pancreatitis Immunofluorescence Fluorescence High Throughput Screening High Content Analysis Antibodies Monoclonal antibodies Show 20 more tags Show less

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Immunohistochemistry (IHC)

Price on request
Request a quote for more information about this service.

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Assay Development

Price on request

3Screen™ - Assay development services based on cleared-tissue image analysis

Customized assay endpoints based on tissue clearing.
Let us help you get the most out of your tissues.

With our extensive portfolio of over 50 High Content Screening assays enhanced by tissue clearing, we are able to tailor any assay to meet your needs.

3Screen™ - Assay development services based on cleared-tissue image analysis

Customized assay endpoints based on tissue clearing.
Let us help you get the most out of your tissues.

With our extensive portfolio of over 50 High Content Screening assays enhanced by tissue clearing, we are able to tailor any assay to meet your needs.

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Cell-Based Compound Screening

Price on request
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Quantitative Histology

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Biology

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Hit Identification

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Biochemistry & Molecular Biology

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Cell-Based Assays

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Clinical Research

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Project Management

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Cell-Based Screening Methods

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Drug Discovery

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Protein Services

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Specialized Cell-Based Assays

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Specialized Cell-Based Assays Services

Specialized Cell-Based Assays Services

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Fluorescence-Based Microscopy

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Fluorescence-Based Microscopy Services

Fluorescence-Based Microscopy Services

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Optical Microscopy

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Optical Microscopy Services

Optical Microscopy Services

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Histopathological Examination

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Immunostaining

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Microscopy

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Microscopy Services

Microscopy Services

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Imaging & Spectroscopy

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Imaging & Spectroscopy Services

Imaging & Spectroscopy Services

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Microscopy Consulting

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Protein Expression Visualization

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Immunofluorescence

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Clinical and Anatomic Pathology

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Drug Discovery & Development

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Image Analysis

Price on request

Image Analysis Services

Image Analysis Services

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Tissue Preparation

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Tissue Preparation Services

Tissue Preparation Services

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Digital Microscopy

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Tissue Processing

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Tissue Processing Services

Tissue Processing Services

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Data Services

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Biospecimens

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Biospecimens Services

Biospecimens Services

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Animal Models and Studies

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Cells and Tissues

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Cells and Tissues Services

Cells and Tissues Services

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Pathology Reports

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Automated Image Analysis

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Visikol is a CRO that is focused on transforming images into insights through the use of advanced optical imaging modalities and digital image analysis. We have developed a suite of automated image analysis tools that we leverage to assist our clients with their image analysis projects. Typically, clients send us either physical... Show more »

Visikol is a CRO that is focused on transforming images into insights through the use of advanced optical imaging modalities and digital image analysis. We have developed a suite of automated image analysis tools that we leverage to assist our clients with their image analysis projects. Typically, clients send us either physical tissues that we transform into digital data sets or digital data sets that we analyze based upon a clients specification. Additionally, we have worked with clients to develop and implement custom automated image analysis algorithms for on-site applications. Our team are experts in image analysis and regularly work with traditional histopathology files (e.g. H&E, IHC) as well as images from optical coherence tomography (OCT) and computed tomography. However, we are agnostic in our approach to image analysis and can develop customized solutions for novel applications.

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Custom Cell-Based Assay Development

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Cell and Tissue Culture

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Tissue Sectioning

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Tissue Embedding

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Histological Staining

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Microscopy Image Analysis

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Histopathology Consulting

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Mammalian Cell Culture

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Mammalian Cell Culture Services

Mammalian Cell Culture Services

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Tissue Section Imaging

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Whole Section Image Analysis

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Preclinical Histology

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Tissue Analysis

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Quantitative Image Analysis

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Histomorphological Analysis

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Ex Vivo Models and Assays

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Histomorphometric Analysis

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Histopathologic Scoring

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Microscopic Analysis

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Preclinical Study Design

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Image Acquisition and Slide Digitization

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Imaging Technology Platforms

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Histology and Pathology Services

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High Throughput Screening (HTS)

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Digital Pathology Services

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Toxicology

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Toxicology Services

Toxicology Services

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Pharmacology & Toxicology

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Pharmacology & Toxicology Services

Pharmacology & Toxicology Services

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