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Velocity Laboratories, LLC

2 Orders Completed
Glen Ellyn, Illinois, US

About Velocity Laboratories, LLC

As innovators in the development of operant pain assays, nobody knows more about the execution and interpretation of preclinical operant pain testing. With over 20 years of experience in preclinical models of pain and addiction, Velocity Laboratories gives in-depth and thorough interpretations, placing your... Show more »

As innovators in the development of operant pain assays, nobody knows more about the execution and interpretation of preclinical operant pain testing. With over 20 years of experience in preclinical models of pain and addiction, Velocity Laboratories gives in-depth and thorough interpretations, placing your results in context to help you identify the most effective analgesic treatments with the least abuse liability.

Key Publications

  • Anderson EM, Mills R, Nolan TA, Jenkins AC, Mustafa G, Lloyd C, Caudle RM, Neubert JK. Use of the Operant Orofacial Pain Assessment Device (OPAD) to measure changes in nociceptive behavior. J Vis Exp. 2013 Jun 10;(76):e50336. doi: 10.3791/50336.
    PMID:23792907
  • Mustafa G, Anderson EM, Bokrand-Donatelli Y, Neubert JK, Caudle RM. Anti-nociceptive effect of a conjugate of substance P and light chain of botulinum neurotoxin type A. Pain. 2013 Nov;154(11):2547-53. doi: 10.1016/j.pain.2013.07.041. Epub 2013 Aug 8.
    PMID:23933181
  • Murphy NP, Mills RH, Caudle RM, Neubert JK. Operant assays for assessing pain in preclinical rodent models: highlights from an orofacial assay. Curr Top Behav Neurosci. 2014;20:121-45. doi: 10.1007/7854_2014_332.
    PMID:25103871
  • Taylor BF, Ramirez HE, Battles AH, Andrutis KA, Neubert JK Analgesic Activity of Tramadol and Buprenorphine after Voluntary Ingestion by Rats (Rattus norvegicus). J Am Assoc Lab Anim Sci. 2016 Jan;55(1):74-82.
    PMID:26817983
  • Rohrs EL, Neubert JK, Caudle RM, Allen KD. Behavioral characteristics of capsaicin mediated cutaneous, myogenic, and arthrogenic orofacial nociception in rats. Arch Oral Biol. 2018 Aug;92:18-24. doi: 10.1016/j.archoralbio.2018.04.013. Epub 2018 Apr 30.
    PMID:29738922
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Our Services (6)


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Pain/Neuropathy Animal Models

Price on request

Velocity Laboratories provides an independent third-party, high-throughput service for preclinical operant pain testing. Our validated reward-conflict-based operant assay evaluates the sensory and affective aspects of pain, better reflecting the human pain condition and offering a major advantage over standard reflex-based pain... Show more »

Velocity Laboratories provides an independent third-party, high-throughput service for preclinical operant pain testing. Our validated reward-conflict-based operant assay evaluates the sensory and affective aspects of pain, better reflecting the human pain condition and offering a major advantage over standard reflex-based pain testing systems.

Different preclinical pain assays mean different things. Velocity Laboratories specializes in operant pain assays that allow access to the higher cognitive aspects of pain.

  • | OPERANT PAIN ASSAYS | REFLEXIVE PAIN ASSAYS
    ------|--------|-----------
    CLINICAL FACE VALIDITY | Yes | No
    REQUIRES | Learned, motivated behavior; spinal-cerebrospinal integration and cortical input | Spinal, supraspinal pathways; motor-efferent pathways
    ASSESSMENT | Cognitive, sensory, emotional | Reflex and unlearned
    INVESTIGATOR | Independent | Dependent
    EXAMPLES | Reward/conflict; place conditioning | Von Frey filaments; thermal plantar
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Analgesic Animal Models

Price on request
Request a quote for more information about this service.

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Substance Abuse Animal Models

Price on request
Request a quote for more information about this service.

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Animal Models of Disease

Price on request

Animal Models of Disease Services

Animal Models of Disease Services

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Animal Models and Studies

Price on request

Animal Models and Studies Services

Animal Models and Studies Services

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CNS/Neurology Animal Models

Price on request

CNS/Neurology Animal Models Services

CNS/Neurology Animal Models Services

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RC

Robert Caudle

Senior Scientist
RM
JN

John Neubert

Senior Scientist
ER

Eric Rohrs

Senior Scientist

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