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VascularStrategies LLC

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North Wales, Pennsylvania, US

About VascularStrategies LLC

Partner with us for access to cutting-edge research services for your drug development. VascularStrategies’ research services portfolio includes both in vitro and in vivo approaches to investigate the role of lipoprotein function in cardiovascular disease. Our company is a complete resource for functional... Show more »

Partner with us for access to cutting-edge research services for your drug development. VascularStrategies’ research services portfolio includes both in vitro and in vivo approaches to investigate the role of lipoprotein function in cardiovascular disease. Our company is a complete resource for functional testing and development of therapeutic candidates for arresting and reversing atherosclerosis through modulation of HDL, Reverse Cholesterol Transport (RCT), and Immune Mediators.

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Our Services (22)


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Cell-Based Assays

Price on request

Additional in vitro and cell-based assays available:

– Human Aortic Endothelial Cell cytokine / adhesion molecule expression assays
– Macrophage cytokine and adhesion molecule expression
– Serum Lipid and Lipoprotein quantitation
– Lipid transfer proteins (CETP, PLTP)
– Lipase activity assays (EL, HL, LPL)
– Serum... Show more »

Additional in vitro and cell-based assays available:

– Human Aortic Endothelial Cell cytokine / adhesion molecule expression assays
– Macrophage cytokine and adhesion molecule expression
– Serum Lipid and Lipoprotein quantitation
– Lipid transfer proteins (CETP, PLTP)
– Lipase activity assays (EL, HL, LPL)
– Serum Apoprotein ELISAs (apo A1, apoB48, apoB100, apo E, apo C3)

VS will also acquire or develop new assays/methodologies to meet client needs.

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Lipid Analysis

Price on request

IN VITRO/EX VIVO ASSAYS

VS provides assessment of serum or therapeutic compound effects on lipoprotein function using the most current in vitro/ex vivo assays:

– ABCA1 cellular cholesterol efflux
– Global cellular cholesterol efflux
– SR-BI cellular cholesterol efflux
– Ex Vivo LCAT activity
– SR-BI mediated cellular... Show more »

IN VITRO/EX VIVO ASSAYS

VS provides assessment of serum or therapeutic compound effects on lipoprotein function using the most current in vitro/ex vivo assays:

– ABCA1 cellular cholesterol efflux
– Global cellular cholesterol efflux
– SR-BI cellular cholesterol efflux
– Ex Vivo LCAT activity
– SR-BI mediated cellular cholesterol uptake
– Cell-free HDL Inflammatory Index (HII)

VS offers preclinical in vivo approaches to assess lipoprotein function in response to therapeutic compounds that can be performed using the most relevant rodent models of atherosclerosis:

– Reverse Cholesterol Transport (RCT)
– Lipoprotein Clearance (HDL, LDL, VLDL)
– Atherosclerosis lesion progression and regression

Newly Licensed First-in-class in vivo technology to measure RCT in humans is breakthrough for assessing cholesterol efflux and RCT selectively from macrophages, and is suitable for clinical trials.

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Lipoprotein Analysis

Price on request
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Atherosclerosis Animal Models

Price on request
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Pharmacology & Toxicology

Price on request
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Assay Development

Price on request

VS will also acquire or develop new assays/methodologies to meet client needs.

VS will also acquire or develop new assays/methodologies to meet client needs.

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Drug Discovery & Development

Price on request
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Lipid Services

Price on request
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Biomarkers

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Bioanalysis

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Drug Discovery

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Cardiovascular Animal Models

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Cardiovascular Animal Models Services

Cardiovascular Animal Models Services

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Animal Models of Disease

Price on request

Animal Models of Disease Services

Animal Models of Disease Services

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Animal Models and Studies

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Animal Models and Studies Services

Animal Models and Studies Services

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Biology

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Biochemistry & Molecular Biology

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Project Management

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Animal Model in vivo Analyses

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In vivo Drug Efficacy Testing

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Pharmacology

Price on request

Pharmacology Services

Pharmacology Services

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In vivo Pharmacology Studies

Price on request

In vivo Pharmacology Studies Services

In vivo Pharmacology Studies Services

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Custom Cardiovascular Animal Models

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Steven Adelman

President and CEO

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