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Vanderbilt University Center for Molecular Probes - Radiochemistry

Nashville, Tennessee, US

In conjunction with the VUIIS synthetic chemistry laboratories, a total of four distinct laboratories are currently setup for the exclusive purpose of radiochemical and radiopharmaceutical preparations. Given the great need for both non-invasive and sensitive diagnostic imaging, both PET and SPECT have seen a reemergence in recent years with a variety of new molecular targeting agents going into clinical trials. Here at VUIIS we have developed a radiochemistry core to stay at the forefront of the exciting developments within this field.

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Radioligand Synthesis/Radiolabeling
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Radiotracers and Radiopharmaceuticals
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Radionuclide Precursors and Intermediates:

[18F]F- in aqueous solution

[18F]F2

68GaCl3 in solution

[11C]CO2 gas

[11C]CH3I methyl iodide

[11C]HCN

[11C]CO

[64Cu]CuCl2 in dilute HCl

[111In] InCl3 in solution

[13N] NH3 - Commercial Products

[18F]FDG (2-fluoro-2-deoxyglucose; glucose... Show more »

Radionuclide Precursors and Intermediates:

[18F]F- in aqueous solution

[18F]F2

68GaCl3 in solution

[11C]CO2 gas

[11C]CH3I methyl iodide

[11C]HCN

[11C]CO

[64Cu]CuCl2 in dilute HCl

[111In] InCl3 in solution

[13N] NH3 - Commercial Products

[18F]FDG (2-fluoro-2-deoxyglucose; glucose metabolism)

[18F]fluoride (bone, fluoride metabolism)

Human Radiopharmaceuticals

[11C]acetate (acetate metabolism, tumor imaging)

[18F]fallypride (dopamine D2/D3)

[18F]FLT for human imaging

[18F]setoperone (serotonin 5-HT2a receptor)

[18F]PBR06

Animal Radiopharmaceuticals:

[18F]FDTBZ (vesicular monoamine transporter)

[18F]FECNT (dopamine transporter)

[18F]FLT (cell proliferation, nucleoside metabolism)

[18F]FMISO (hypoxia, tumor imaging) § [64Cu]copper-
ATSM (cell hypoxia, tumor imaging)

[11C]DTBZ (VMAT2, vesicular monoamine transporter)

[18F]FPEB (mGluR5, metabotropic glutamate receptor)

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Radiochemistry
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Chemistry and Materials
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