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Us4Cure, Inc

Agoura Hills, California, US

Us4Cure, Inc. is a biospecimen procurement company operated by a highly experienced management team. Our knowledge and experience allow us to organize tissue procurement projects in the most optimal way in accordance with the highest standards and regulations accepted in the field.

Our Values:

  • Personal Approach and Communication
  • Attention to Details
  • Responsiveness and Accountability
  • Operational Transparency
  • Quality Standards
  • Cost Effectiveness and Value Creation

Core Capabilities:

Project Planning
Site Management
Management of ongoing projects
Quality Compliance

Us4Cure, Inc has not listed any services.

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Human Biofluids
Price on request
  • Urine
  • Saliva
  • Ascites Fluid
  • Cerebrospinal Fluid (CSF)
  • Stool/Feces
  • Amniotic fluid
  • Urine
  • Saliva
  • Ascites Fluid
  • Cerebrospinal Fluid (CSF)
  • Stool/Feces
  • Amniotic fluid
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Human Tissue Procurement
Price on request

FFPE

FFPE tissue samples are fixed in 10% neutral-buffered formalin within 30 minutes of surgery excision. Tissue samples are fixed for 18 hours and embedded in IHC-grade paraffin. Standard sample size is 1 x 1 x 0.5 cm. The fixation agent and the embedding media can be customized upon request.

*Quality Control... Show more »

FFPE

FFPE tissue samples are fixed in 10% neutral-buffered formalin within 30 minutes of surgery excision. Tissue samples are fixed for 18 hours and embedded in IHC-grade paraffin. Standard sample size is 1 x 1 x 0.5 cm. The fixation agent and the embedding media can be customized upon request.

Quality Control Procedure

The initial review of the samples is performed by the Quality Control Manager at the Pathology laboratory.
Initial review assesses and confirms the following:

  • Proper sample format and condition
  • Sample size
  • Proper labeling
  • Tissue specimens should not be larger than 1 x 1 x 0.5 cm.

Pathology Review of the Samples

Basic quality control practice includes a morphologic review of H&E stained slides;
The review is performed by an independent MD pathologist.
Pathology review (made by a certified MD pathologist) includes:

  • Tissue type and assessment of diagnosis;
  • Tumor type;
  • Presence of tumor;
  • Cell content of tumor and stromal area by percentage;
  • Percentage of tumor necrosis;
  • Presence of artifacts.

The following standard clinical information will be provided for each sample:

  • Basic information (age, ethnicity, height, weight, gender)
  • Date of sample procurement
  • Clinical diagnosis (tumor location, type, stage, grade, TNM)

The pathology report can include information about standard molecular markers, for instance ER, PR, HER2 status for breast cancer.

FRESH FROZEN

Fresh frozen tissue samples are snap-frozen in liquid nitrogen within 30 minutes of surgery excision. Standard sample weight is 200-300 mg. Fresh frozen tissue sample collection is performed strictly following the Us4Cure SOP. Samples can be collected in embedding media upon request.

The following standard clinical information will be provided for each sample:

  • Basic information (age, ethnicity, height, weight, gender)
  • Date of sample procurement
  • Clinical diagnosis (tumor location, type, stage, grade, TNM)
  • Pathology report
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Human Whole Blood
Price on request

Us4Cure collects up to 30 - 50 ml of whole blood from one donor. Blood samples can be collected in:

  • Special tubes for further isolation of plasma, serum or PBMCs
  • Special tubes for further DNA or RNA extraction

Us4Cure collects up to 30 - 50 ml of whole blood from one donor. Blood samples can be collected in:

  • Special tubes for further isolation of plasma, serum or PBMCs
  • Special tubes for further DNA or RNA extraction
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Biospecimens
Price on request

All clinical materials are obtained following validated protocols, in conjunction with the Institutional Review Board (IRB)/Ethical committee's approval in accordance with ICH and GCP guidelines.


We provide electronic biospecimen tracking, storage and shipping services.
All our samples can be labeled with a matching... Show more »

All clinical materials are obtained following validated protocols, in conjunction with the Institutional Review Board (IRB)/Ethical committee's approval in accordance with ICH and GCP guidelines.


We provide electronic biospecimen tracking, storage and shipping services.
All our samples can be labeled with a matching barcode, QR code, and alpha-numeric identifier. We can print a secondary label for our samples according to your request.
Our biospecimens are consistent due to our rigorous staff training, exhaustive operating protocols for collections, and quality control system.
Certified pathologists validate biospecimens to ensure correct diagnosis, proper fixation, and to confirm the tissue characteristics.
All donors are screened for the absence of HCV, HBV and HIV infections before tissue procurement unless these diseases are a subject of the study requested by the client.

Type of Samples collection

Biospecimens are offered in several formats to meet research needs:

  • Fresh frozen (FF) tissue samples and biofluids, formalin fixed paraffin embedded (FPPE) tissue samples, or tissues otherwise preserved as requested. We can separate whole blood into different fractions (plasma, serum, PBMCs, buffy coat) and dissociate fresh tissue into individual viable cells.
  • A tumor and matched adjacent normal tissue.
  • A matched pair of specimens provided in both FFPE and fresh frozen (FF) formats that are derived from the same tumor.
  • A full set of specimens from the same patient: a matched pair of FF and FFPE tissues with an accompanying set of biofluids (whole blood, serum, plasma, etc.).
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Human Plasma and Serum
Price on request

Us4Cure collects up to 10 - 15 ml serum per donor per blood draw.

Serum samples are collected according to the Us4Cure SOPs.

Us4Cure can perform custom collection using clients' SOPs, protocols, and collection tubes.

Serum samples are processed and frozen at - 20°C within 2 hours after blood draw and then are... Show more »

Us4Cure collects up to 10 - 15 ml serum per donor per blood draw.

Serum samples are collected according to the Us4Cure SOPs.

Us4Cure can perform custom collection using clients' SOPs, protocols, and collection tubes.

Serum samples are processed and frozen at - 20°C within 2 hours after blood draw and then are transferred to - 80°C within 72 hours for long-term storage.

A standard serum aliquot is 1 mL. Different aliquot sizes can be collected upon client's request.

Serum samples are checked for hemolysis after processing by the research nurse.

Hemolyzed samples are discarded and not stored for distribution. The Quality Control Manager performs review of the samples before shipment.

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PBMC Isolation
Peripheral Blood Mononuclear Cell Isolation
Price on request

PBMCs or BMMCs can be isolated from whole blood or bone marrow aspirate respectively. Isolated cells are cryopreserved and stored in liquid nitrogen vapor. Each vial of viable PBMCs or BMMCs contains at least 5 x 10E6 cells.

PBMCs or BMMCs can be isolated from whole blood or bone marrow aspirate respectively. Isolated cells are cryopreserved and stored in liquid nitrogen vapor. Each vial of viable PBMCs or BMMCs contains at least 5 x 10E6 cells.

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DNA Extraction
Price on request

DNA and RNA specimens can be isolated from fresh tissue, FF tissue, FFPE tissue and peripheral blood procured from patients and normal donors.

DNA and RNA specimens can be isolated from fresh tissue, FF tissue, FFPE tissue and peripheral blood procured from patients and normal donors.

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RNA Extraction
Price on request

DNA and RNA specimens can be isolated from fresh tissue, FF tissue, FFPE tissue and peripheral blood procured from patients and normal donors.

DNA and RNA specimens can be isolated from fresh tissue, FF tissue, FFPE tissue and peripheral blood procured from patients and normal donors.

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Mutation Analysis
Price on request

Subcontracted laboratories of Us4Cure provide a wide offering of mutation screening using real-time PCR.
Us4Cure screens for the following gene mutations:

  • Breast Cancer KRAS, BRCA, PI3K
  • Lung cancer – EGFR, KRAS, EML4-ALK
  • Colorectal cancer – KRAS, BRAF, NRAS, PIK3CA
  • Melanoma – BRAF, NRAS
  • Leukemia – BCR-ABL,... Show more »

Subcontracted laboratories of Us4Cure provide a wide offering of mutation screening using real-time PCR.
Us4Cure screens for the following gene mutations:

  • Breast Cancer KRAS, BRCA, PI3K
  • Lung cancer – EGFR, KRAS, EML4-ALK
  • Colorectal cancer – KRAS, BRAF, NRAS, PIK3CA
  • Melanoma – BRAF, NRAS
  • Leukemia – BCR-ABL, PML-RARA, E2A-PBX1, AML1-ETO, MLL-AF4, TEL-AML1

Other types of cancer could be screened upon request of the client.

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Human Whole Blood & PBMCs
Price on request
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Nucleic Acid Services
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Human Biospecimens
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Mutagenesis
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Biology
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Human Biospecimen Collection
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Cells and Tissues
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RNA Services
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DNA Extraction and Purification
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Biochemistry & Molecular Biology
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DNA Services
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2018-03-09 02:04:37 -0800

Net Promoter Score of 10 received for Human Tissue Procurement.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 9.
2018-02-23 11:21:07 -0800

Net Promoter Score of 10 received for Human Tissue Procurement.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-12-22 06:32:23 -0800

Net Promoter Score of 10 received for Biospecimens.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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