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UNC Nanomedicines Characterization Core Facility

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Chapel Hill, North Carolina, US

About UNC Nanomedicines Characterization Core Facility

The University of North Carolina at Chapel Hill is a world leader in nanomedicine and drug delivery research. It houses a Center for Nanotechnology in Drug Delivery (CNDD), a joint venture between the UNC Eshelman School of Pharmacy and the UNC School of Medicine. The Center has established a new core facilitiy... Show more »

The University of North Carolina at Chapel Hill is a world leader in nanomedicine and drug delivery research. It houses a Center for Nanotechnology in Drug Delivery (CNDD), a joint venture between the UNC Eshelman School of Pharmacy and the UNC School of Medicine. The Center has established a new core facilitiy the Nanomedicines Characterization Core that accelerates translation of new Nanomedicines to clinic by providing their comprehensive physicochemical characterization.

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Our Services (15)


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Isoelectric Focusing (IEF)

Price on request

PA 800 Plus Pharmaceutical Analysis System (SCIEX, Framingham, MA)
- Automated and Quantitative Analysis of Biotherapeutics
- Highly reproducible data
Key applications:
- Quantitative protein purity analysis with SDS-Gel Capillary Electrophoresis
- Advanced capillary isoelectric focusing and hi-speed Capillary Zone Electrophoresis... Show more »

PA 800 Plus Pharmaceutical Analysis System (SCIEX, Framingham, MA)
- Automated and Quantitative Analysis of Biotherapeutics
- Highly reproducible data
Key applications:
- Quantitative protein purity analysis with SDS-Gel Capillary Electrophoresis
- Advanced capillary isoelectric focusing and hi-speed Capillary Zone Electrophoresis for charge heterogeneity analysis
- Glycan analysis
- Peptide and protein biotherapeutics beyond mAbs
- Plasmid/Nucleic Acid purity, heterogeneity and sizing analysis

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Glycan Analysis

Price on request

PA 800 Plus Pharmaceutical Analysis System (SCIEX, Framingham, MA)
- Automated and Quantitative Analysis of Biotherapeutics
- Highly reproducible data
Key applications:
- Quantitative protein purity analysis with SDS-Gel Capillary Electrophoresis
- Advanced capillary isoelectric focusing and hi-speed Capillary Zone Electrophoresis... Show more »

PA 800 Plus Pharmaceutical Analysis System (SCIEX, Framingham, MA)
- Automated and Quantitative Analysis of Biotherapeutics
- Highly reproducible data
Key applications:
- Quantitative protein purity analysis with SDS-Gel Capillary Electrophoresis
- Advanced capillary isoelectric focusing and hi-speed Capillary Zone Electrophoresis for charge heterogeneity analysis
- Glycan analysis
- Peptide and protein biotherapeutics beyond mAbs
- Plasmid/Nucleic Acid purity, heterogeneity and sizing analysis

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Western Blot

Price on request

Wes (Protein Simple, San Jose, CA)
- Highly sensitive automated Western blotting system
- Can run 25 samples simultaneously
- Can detect protein at the nanogram level in nanoliter-volume samples
- Three-hour run time
Sample Required: 0.3-1.2 µg
Volume Required: 3 µL/well
Size Range: 2-440 kDa
Resolution: ± 15-20% for MW <20... Show more »

Wes (Protein Simple, San Jose, CA)
- Highly sensitive automated Western blotting system
- Can run 25 samples simultaneously
- Can detect protein at the nanogram level in nanoliter-volume samples
- Three-hour run time
Sample Required: 0.3-1.2 µg
Volume Required: 3 µL/well
Size Range: 2-440 kDa
Resolution: ± 15-20% for MW <20 kDA, ± 10% for MW >20 kDa
Dynamic Range: 2-3 logs
Sensitivity: ng
Key applications:
- Qualitative detection of single proteins and protein-modifications
- Same-day verification of protein expression
- Quantitative protein expression data

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FT-IR

Fourier transform infrared spectroscopy
Price on request

Nicolet 380 (ThermoFisher Scientific, Waltham, MA)
- Reveal the composition of solids and liquids
- Easy to use, sensitive and fast
Key applications:
- Routine FT-IR analysis in the mid-IR region
- Material identification and verification
- Formulation development and validation
- Quality control processes for incoming and... Show more »

Nicolet 380 (ThermoFisher Scientific, Waltham, MA)
- Reveal the composition of solids and liquids
- Easy to use, sensitive and fast
Key applications:
- Routine FT-IR analysis in the mid-IR region
- Material identification and verification
- Formulation development and validation
- Quality control processes for incoming and outgoing materials
- Copolymer and blend assessment
- Additive identification and quantification
- Contaminant identification
- Molecular degradation assessment

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Zeta Potential Measurements

Price on request

Zetasizer Nano ZS (Malvern Panalytical, Ltd, UK)
- Simple, rapid, repeatable and non-destructive technique
- Low volume sample measurement (for valuable proteins and biopolymer samples)
Light Source: 633 nm
Accuracy: Better than +/-2% on NIST traceable latex standards 0.12µm.cm/V.s for aqueous systems using NIST, SRM1980 standard... Show more »

Zetasizer Nano ZS (Malvern Panalytical, Ltd, UK)
- Simple, rapid, repeatable and non-destructive technique
- Low volume sample measurement (for valuable proteins and biopolymer samples)
Light Source: 633 nm
Accuracy: Better than +/-2% on NIST traceable latex standards 0.12µm.cm/V.s for aqueous systems using NIST, SRM1980 standard reference material
Size range for Zeta potential: 3.8 nm to 100 μm
Key applications:
- Zeta potential measurements
- Stability over time in physiological buffers, cell culture medium, blood serum and polyelectrolyte substitution/exchange

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Dynamic Light Scattering

Price on request

Zetasizer Nano ZS (Malvern Panalytical, Ltd, UK)
- Simple, rapid, repeatable and non-destructive technique
- Low volume sample measurement (for valuable proteins and biopolymer samples)
Light Source: 633 nm
Accuracy: Better than +/-2% on NIST traceable latex standards 0.12µm.cm/V.s for aqueous systems using NIST, SRM1980 standard... Show more »

Zetasizer Nano ZS (Malvern Panalytical, Ltd, UK)
- Simple, rapid, repeatable and non-destructive technique
- Low volume sample measurement (for valuable proteins and biopolymer samples)
Light Source: 633 nm
Accuracy: Better than +/-2% on NIST traceable latex standards 0.12µm.cm/V.s for aqueous systems using NIST, SRM1980 standard reference material
Size range (diameter): 0.3 nm to 10 μm
Size range for Zeta potential: 3.8 nm to 100 μm
Key applications:
- Proteins and polymer analysis
- Size determination
- Polydispersity index determination
- Zeta potential measurements
- Stability over time in physiological buffers, cell culture medium, blood serum and polyelectrolyte substitution/exchange

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Environmental Contaminant Measurement

Price on request
  • Our Inductively Coupled Plasma Mass Spectrometry System is a great technique for Heavy metals poisoning, soils and water quality analysis, food and plant studies.
  • A Capillary Electrophoresis method has been developed and validated for determination of organic acids (oxalate, tartrate, malate, malonate, pyruvate, succinate,... Show more »
  • Our Inductively Coupled Plasma Mass Spectrometry System is a great technique for Heavy metals poisoning, soils and water quality analysis, food and plant studies.
  • A Capillary Electrophoresis method has been developed and validated for determination of organic acids (oxalate, tartrate, malate, malonate, pyruvate, succinate, acetate, citrate, and lactate) and inorganic anions (sulfate and phosphate) in red wines .
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Biodistribution Studies

Price on request
  • Inductively Coupled Plasma Mass Spectrometry provides an opportunity for concentration measurement of metal-containing proteins/formulations, cell uptake studies, bio distribution studies without use of radioactive materials.
  • Check our High Performance Liquid Chromatography System which can be used to identify the specific... Show more »
  • Inductively Coupled Plasma Mass Spectrometry provides an opportunity for concentration measurement of metal-containing proteins/formulations, cell uptake studies, bio distribution studies without use of radioactive materials.
  • Check our High Performance Liquid Chromatography System which can be used to identify the specific molecule or component for bioavailabilty studies, drug release from the formulation, dissolution studies etc.
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Protein Characterization

Price on request
  • Capillary Electrophoresis is robust analytical platform that provides characterization of product purity, charge heterogeneity, and glycan analysis with high reproducibility.
  • Simple Westerns/Western blot System lets you separate and analyze proteins by size from 2-440 kDa with just 3 µL of starting material.
  • NCore provide... Show more »
  • Capillary Electrophoresis is robust analytical platform that provides characterization of product purity, charge heterogeneity, and glycan analysis with high reproducibility.
  • Simple Westerns/Western blot System lets you separate and analyze proteins by size from 2-440 kDa with just 3 µL of starting material.
  • NCore provide the opportunity to run traditional BCA-Assay using our Multi-Mode Microplate Reader.
  • Our Western Blot and Gel Imager is optimized for superior analysis of chemiluminescent conventional Western blots.
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Nanoscale Analysis and Characterization

Price on request
  • Particle size and surface charge:
    Malvern Zetasizer Nano ZS is a non-destructive, simple and powerful tool for measuring hydrodynamic diameter (particle size), zeta potential (surface charge), and size distribution (polydispersity) as well as stability of the particles over the time and temperature dependence.
  • Particle size... Show more »
  • Particle size and surface charge:
    Malvern Zetasizer Nano ZS is a non-destructive, simple and powerful tool for measuring hydrodynamic diameter (particle size), zeta potential (surface charge), and size distribution (polydispersity) as well as stability of the particles over the time and temperature dependence.
  • Particle size and concentration:
    Nanoparticle Tracking Analysis System provides quantitative characterization data including particle size and sample concentration. The general size range varies from 40 nm – 1 µm. In addition to samples analyzed by conventional NTA also possesses additional capabilities to analyze fluorescently labeled nanomaterials.
    Single particles ICP-MS proving invaluable for detecting and sizing metallic nanoparticles at very low elemental concentrations. Its combination of elemental specificity, sizing resolution, and unmatched sensitivity makes it extremely applicable for the characterization of particles containing elements such as Ag, Au, Ti (TiO2), and others.
  • Composition of inorganic/organic components:
    Inductively Coupled Plasma Mass Spectrometer might be used to conduct elemental/isotope analysis of over 100 different elements present at concentrations as low as 1 ppt (depending on analyte nature).
    Determine total organic material content and the composition of the organic coating based on signature decomposition patterns using our Thermal gravimetric analysis System. Self- Service available.
  • Average molar mass, size and solubility:
    Static light scattering technique will help you to determine Average molecular mass of your polymer/nanoparticles as well as radius of gyration (size) and solubility (second virial coefficient). Self-
    GPC is an analytical technique in which particles/polymers are separated based on their hydrodynamic volume. Our technical capabilities can provide a distribution of absolute molecular weight, intrinsic viscosity as well as information on macromolecular structure, conformation aggregation and branching.
  • Formulation validation/Quality control:
    Our Fourier-transform infrared spectrometer will help you verify/validate your formulation as well as confirm quality and contamination absence. Self-Service available.
    High Performance Liquid Chromatography can be used in drug development, as it is a dependable way to obtain and ensure product purity.
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Exosome Isolation and Characterization

Price on request

Size/Concentration: NTA-based Exosome Characterization Service can give you an understanding of the quality of your exosomes. Send/Bring us your exosomes and we will give you a report with the particle analysis data - the mean and mode diameter size, standard deviation, distribution by sizes and particle concentration... Show more »

Size/Concentration: NTA-based Exosome Characterization Service can give you an understanding of the quality of your exosomes. Send/Bring us your exosomes and we will give you a report with the particle analysis data - the mean and mode diameter size, standard deviation, distribution by sizes and particle concentration (particles/ml all gathered in five replicates.
Dynamic Light Scattering (DLS) is a fast method to characterize your monodispersed exosomes. It will give you an information about size and polydispersity of your particles. Only 50uL of the samples required.
Surface charge: Zeta potential meter will help you analyze a surface charge of the particles.
Protein quantification: NCore provide the opportunity to run traditional BCA-Assay using our Multi-Mode Microplate Reader.
Simple Westerns/Western blot System lets you separate and analyze proteins by size from 2-440 kDa with just 3 µL of starting material. Got a lot of samples and no time? Wes runs up to 25 samples in 3 hours flat and gives you quantitative, size-based data including total protein. Self- Service available.

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Zetasizer Nano ZS ProteinSimple WES NanoSight NS500

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Nanoparticle Tracking Analysis

Price on request

NanoSight NS500 (Malvern Panalytical, Ltd, UK)
- Detailed and straight forward analysis of size distribution and concentration
- Visual validation of results gives extra confidence
- Minimal sample preparation
Laser Wavelength: 532 nm
Long pass fluorescent filter: 565 nm
Particles range: 30 nm to 1000 nm
Concentration: 10^7 to... Show more »

NanoSight NS500 (Malvern Panalytical, Ltd, UK)
- Detailed and straight forward analysis of size distribution and concentration
- Visual validation of results gives extra confidence
- Minimal sample preparation
Laser Wavelength: 532 nm
Long pass fluorescent filter: 565 nm
Particles range: 30 nm to 1000 nm
Concentration: 10^7 to 10^9 particles per ml
Sample volume: 20 – 100 ul
Key applications:
- Exosomes and microvesicles (extracellular vesicles) characterization
- Nanoparticles characterization
- Fluorescently labelled exosome and nanoparticles analysis
- Size distribution and polydispersity
- Sample concentration (particles/ml)
- Aggregation studies

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Capillary Electrophoresis

Price on request

PA 800 Plus Pharmaceutical Analysis System (SCIEX, Framingham, MA)
- Automated and Quantitative Analysis of Biotherapeutics
- Highly reproducible data
Key applications:
- Quantitative protein purity analysis with SDS-Gel Capillary Electrophoresis
- Advanced capillary isoelectric focusing and hi-speed Capillary Zone Electrophoresis... Show more »

PA 800 Plus Pharmaceutical Analysis System (SCIEX, Framingham, MA)
- Automated and Quantitative Analysis of Biotherapeutics
- Highly reproducible data
Key applications:
- Quantitative protein purity analysis with SDS-Gel Capillary Electrophoresis
- Advanced capillary isoelectric focusing and hi-speed Capillary Zone Electrophoresis for charge heterogeneity analysis
- Glycan analysis
- Peptide and protein biotherapeutics beyond mAbs
- Plasmid/Nucleic Acid purity, heterogeneity and sizing analysis

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ICP-MS

Inductively Coupled Plasma Mass Spectrometry
Price on request

NexION 300D (PerkinElmer, Inc., Waltham, MA)
- Ability to analyze most of the frequently use elements in the periodic table (Mg, Al, P, Sc, Ti, Cr, Mn, Fe, Ni, Cu, Zn, Ge, As, Zr, Mo, Ag, Cd, In, An, Ce, Gd, Tb, Ir, Pt, Au, Hg, Pb, Bi, and others)
- Wide dynamic range: Part-per-trillion to high part-per-million
- Only technique... Show more »

NexION 300D (PerkinElmer, Inc., Waltham, MA)
- Ability to analyze most of the frequently use elements in the periodic table (Mg, Al, P, Sc, Ti, Cr, Mn, Fe, Ni, Cu, Zn, Ge, As, Zr, Mo, Ag, Cd, In, An, Ce, Gd, Tb, Ir, Pt, Au, Hg, Pb, Bi, and others)
- Wide dynamic range: Part-per-trillion to high part-per-million
- Only technique which can detect toxic heavy metals As, Cd, Hg and Pb as low as 10 pg/ml
- Data system that allows corrections for isobaric interferences and the application of the internal standard technique
Resolution: less than or equal to 0.9 amu at 10% peak height from 6-253 amu and 1.0 amu at 5% peak height from 6-253 amu
Short-term precision: < 3% Relative Standard Deviation (RSD)
Long-term stability: < 4% RSD over 4 hours
Isotope-ratio precision: < 0.08*% RSD (*or within a factor of two of the counting statistics limit)
Mass calibration stability: < 0.05 amu over 8 hours of continuous operation

Key applications:
- Concentration measurement of metal-containing proteins
- Cell uptake studies
- Drug loading/drug release
- Biodistribution studies
- Heavy metals poisoning
- Soils and water quality analysis
- Food studies
- Plants studies

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Polymer Characterization

Price on request
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Olesia Gololobova

Research Specialist

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