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UCSC Paleogenomics Lab

Santa Cruz, California, US

Welcome to our lab! The Paleogenomics Lab is a joint venture between two PIs: Beth Shapiro, and Richard (Ed) Green (see Ed's lab website in BME). Our research focuses on a wide range of evolutionary and ecological questions, mostly involving the application of genomics techniques to better understand how species and populations evolve through time. Our groups incorporate experimental and computational approaches. We generate new data and devise new approaches to their analysis, such as tools to assemble genomes and to analyze genomic and population genetic data. Our interests are broad, spanning human evolution, genome assembly and analysis, pathogen evolution, population genetics and the genomic consequences of long-term environmental change.

Recent Publications:

  • Heintzman PD, Zazula GD, Cahill JA, MacPhee RDE, Shapiro B, Genomic data from extinct North American Camelops revises camel evolutionary... Show more »

Welcome to our lab! The Paleogenomics Lab is a joint venture between two PIs: Beth Shapiro, and Richard (Ed) Green (see Ed's lab website in BME). Our research focuses on a wide range of evolutionary and ecological questions, mostly involving the application of genomics techniques to better understand how species and populations evolve through time. Our groups incorporate experimental and computational approaches. We generate new data and devise new approaches to their analysis, such as tools to assemble genomes and to analyze genomic and population genetic data. Our interests are broad, spanning human evolution, genome assembly and analysis, pathogen evolution, population genetics and the genomic consequences of long-term environmental change.

Recent Publications:

  • Heintzman PD, Zazula GD, Cahill JA, MacPhee RDE, Shapiro B, Genomic data from extinct North American Camelops revises camel evolutionary history. Molecular Biology and Evolution (2015)
  • Vohr SH, Green RE, Development: Aneuploidy and mother's genes. *Science *348: 180-181 (2015)
  • Cahill JA, Green RE, Kistler L, Salamzade R, Ersmark E, Fulton TL, Stiller M, Shapiro B, Genomic evidence of geographically widespread effect of gene flow from polar bears into brown bears. Molecular Ecology 24: 1205-1217 (2015)
  • Wooller M, Gaglioti B, Fulton TL, Shapiro B, Post-glacial dispersal of northern pike (Esox cf. lucius) in Eastern Beringia inferred using radiocarbon and ancient DNA results from an 8,800 year old fish skull preserved in Quartz Lake, interior Alaska. Quaternary Science Reviews 120: 118-125. (2015)
  • Seguin-Orlando A, Hoover C, Vasiliev S, Ovodov ND, Shapiro B, Cooper A, Rubin E, Willerslev E, Orlando L, Amplification bias in TruSeq DNA libraries uncovers ancient methylation signatures. Science and Technology of Archaeological Research (STAR) 1: 112054892315Y.0000000005 (2015)
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UCSC Paleogenomics Lab has not listed any services.

DNA quantification
Price on request
Service Within-UC Rate External Client Rate
DNA High Sensitivity Analysis (1-11 samples) $87 $134
Service Within-UC Rate External Client Rate
DNA High Sensitivity Analysis (1-11 samples) $87 $134
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Genomic DNA extraction
Price on request
Service Within-UC Rate External Client Rate
Ancient DNA Extraction (1st sample) $425 $653
Ancient DNA Extraction (samples 2-11) $54 $83
Service Within-UC Rate External Client Rate
Ancient DNA Extraction (1st sample) $425 $653
Ancient DNA Extraction (samples 2-11) $54 $83
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Illumina NGS
Illumina Next Generation Sequencing
Price on request
Service Within-UC Rate External Client Rate
MiSeq Run - 150 Cycle V3 $1514 $2324
MiSeq Run - 600 Cycle V3 $2279 $3499
MiSeq Run - 50 Cycle V2 $1419 $2179
MiSeq Run - 300 Cycle V2 $1680 $2579
MiSeq Run - 500 Cycle V2 $1814 $2785

NGS... Show more »

Service Within-UC Rate External Client Rate
MiSeq Run - 150 Cycle V3 $1514 $2324
MiSeq Run - 600 Cycle V3 $2279 $3499
MiSeq Run - 50 Cycle V2 $1419 $2179
MiSeq Run - 300 Cycle V2 $1680 $2579
MiSeq Run - 500 Cycle V2 $1814 $2785
NGS Library Prep (w/barcodes) (1st sample) $459 $705
NGS Library Prep (w/barcodes) (samples 2-11) $42 $65
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Data Management Services
Starting at $96.00 per hour
Service Within-UC Rate External Client Rate
Data Analysis (per hour) $62 $96
Service Within-UC Rate External Client Rate
Data Analysis (per hour) $62 $96
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July 22, 2016

Positive review received for Illumina NGS:

"I've now completed three orders with the UCSC Paleogenomics team. I've always been extremely happy with the standard of their work and the invaluable consultation they provide. I highly recommend making use of this rock-star team to assist you with your ancient DNA project."

February 16, 2016

Positive review received for Illumina NGS:

"The team at UCSC Paleogenomics Lab always provide work of the highest standard. The Science Exchange platform provides citizen scientists like me access to world leading experts. The implications of that improved accessibility are profound. I look forward to collaborating with the UCSC Paleogenomics Lab again in future."

September 22, 2015

Positive review received for Illumina NGS:

"Beth and Lily were extremely helpful and responsive. Beth went above and beyond the requirements of the order to give invaluable advice that will steer the direction of the Moa Revival Project in general. I look forward to working with the UCSC Paleogenomics Lab again in the near future."

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