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Ubigene Biosciences Co., Ltd.

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Guangzhou, Guangdong, CN

About Ubigene Biosciences Co., Ltd.

Ubigene Biosciences is co-founded by biological academics and elites from China, the United States, and France. We are located in Guangzhou Science City, which serves as a global center for high technology and innovation. Ubigene Biosciences has 1000㎡ office areas and laboratories, involving genome editing, cell biology technology, and zebrafish research. We provide...

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Ubigene Biosciences is co-founded by biological academics and elites from China, the United States, and France. We are located in Guangzhou Science City, which serves as a global center for high technology and innovation. Ubigene Biosciences has 1000㎡ office areas and laboratories, involving genome editing, cell biology technology, and zebrafish research. We provide products and services for plasmids, viruses, cells, and zebrafish. We aim to provide customers with better gene-editing tools for cell or animal research.

 

Make genome editing easier is the goal of Ubigene. We developed CRISPR-U™ (based on CRISPR/Cas9 technology) which is more efficient than general CRISPR/Cas9 in double-strand breaking, and CRISPR-U™ can greatly improve the efficiency of homologous recombination, easily achieve knockout (KO), point mutation (PM) and knockin (KI) in vitro and in vivo. With CRISPR-U™, Ubigene has successfully edit genes on more than 100 cell lines.

 

Ubigene developed CRISPR-B™ which optimizes the microbial gene-editing vectors and process. The efficiency and accuracy are much higher than traditional methods. CRISPR-B™ can be used in gene editing of bacteria and fungi. Easily achieve microbial gene knockout (KO), point mutation (PM) and knockin (KI).

 

Ubigene has more than 400 types of primary cells, including epithelial cells, endothelial cells, smooth muscle cells and fibroblasts from different species, such as human, rat, and mouse. We can provide a validation report for each primary cell. Our primary cells have been widely used in many research institutes and pharmaceutical enterprises.

 

Pragmatism, efficiency, integrity are our business principles. We are committed to providing the best services and products to every customer who chooses us.

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Our Services (13)


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Knockout Cell Lines

Price on request

$2020  For HEK293, CHO, Hela, HCT116, A549!

$3030  For Vero, HuH-7, HepG2, THP-1, MDA-MB-231, AGS, NCI-H1299, U251, KYSE-150, H9C2.

$4040 For 100 types of cell lines Ubigene had successfully modified!

Inquiry for iPSC & ESC!

CRISPR-U™, developed by Ubigene, is more efficient than... Show more »

$2020  For HEK293, CHO, Hela, HCT116, A549!

$3030  For Vero, HuH-7, HepG2, THP-1, MDA-MB-231, AGS, NCI-H1299, U251, KYSE-150, H9C2.

$4040 For 100 types of cell lines Ubigene had successfully modified!

Inquiry for iPSC & ESC!

CRISPR-U™, developed by Ubigene, is more efficient than general CRISPR/Cas9 in double-strand breaking, and CRISPR-U™ can greatly improve the efficiency of homologous recombination, easily achieve knockout (KO), point mutation (PM) and knockin (KI) in vitro and in vivo.

 

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Biology Drug Discovery Neuroscience Toxicology Pharmacology CRISPR Cas9 CRISPR Cas9 Gene Editing Technology CRISPER Cas9 cell lines Cell lines Human Mice Rat Gene List Show 14 more tags Show less

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Cell Line Engineering - gene repression

Starting at $2,980.00 per cell line

RNAi stable cell line/Knockdown cell line: 2980 USD, 6-7 weeks.

The knockdown vector would be transferred into the cells by lentivirus transduction. After drug screening, WT cells die out and a positive cell pool obtained.

 

RNAi stable cell line/Knockdown cell line: 2980 USD, 6-7 weeks.

The knockdown vector would be transferred into the cells by lentivirus transduction. After drug screening, WT cells die out and a positive cell pool obtained.

 

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Cell Line Engineering - Expression of Exogenous Gene

Starting at $3,980.00 per cell line

Gene overexpression stable cell line service: 3980 USD, 6-8 weeks

The overexpression vector would be transferred into the cells by lentivirus transduction or piggyBac transposition. After drug screening, WT cells die out and a positive cell pool obtained.

Gene overexpression stable cell line service: 3980 USD, 6-8 weeks

The overexpression vector would be transferred into the cells by lentivirus transduction or piggyBac transposition. After drug screening, WT cells die out and a positive cell pool obtained.

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Knockout Bacteria

Starting at $3,880.00 per cell line

Genome Editing Microbes    3880 USD
Genome Editing E. Coli         2020 USD

Ubigene optimized the microbial gene-editing vectors and process, and developed CRISPR-B™. The efficiency and accuracy are 20 times higher than traditional methods.

Genome Editing Microbes    3880 USD
Genome Editing E. Coli         2020 USD

Ubigene optimized the microbial gene-editing vectors and process, and developed CRISPR-B™. The efficiency and accuracy are 20 times higher than traditional methods.

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Cell Line Engineering - Knock-In

Starting at $9,980.00 per cell line

Point Mutation Cell Lines : The cells would be co-transfected with gRNA, Cas9 and donor oligo by electroporation, and then screened. After drug screening, single clones would be generated. Positive clones would be validated by sequencing.

CRISPR-U™, developed by Ubigene, is more efficient than general CRISPR/Cas9... Show more »

Point Mutation Cell Lines : The cells would be co-transfected with gRNA, Cas9 and donor oligo by electroporation, and then screened. After drug screening, single clones would be generated. Positive clones would be validated by sequencing.

CRISPR-U™, developed by Ubigene, is more efficient than general CRISPR/Cas9 in double-strand breaking, and CRISPR-U™ can greatly improve the efficiency of homologous recombination, easily achieve knockout (KO), point mutation (PM) and knockin (KI) in vitro and in vivo.

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Adenovirus Production

Price on request

Adenovirus is a linear and double-stranded DNA virus that without a surface envelope. It can infect both divisive and non-divisive cells. Recombinant adenovirus can enter cells through receptor-mediated endocytosis, while its genome is not integrated with the host cell genome. Adenovirus is widely used in the researches of... Show more »

Adenovirus is a linear and double-stranded DNA virus that without a surface envelope. It can infect both divisive and non-divisive cells. Recombinant adenovirus can enter cells through receptor-mediated endocytosis, while its genome is not integrated with the host cell genome. Adenovirus is widely used in the researches of cardiovascular, liver, muscle, lung, cancer and other fields. It has the characteristics of wide host range, strong immunogenicity, large capacity, no integration with the genome, transient expression and so on. To ensure the safety, human adenovirus type 5 (Ad5), which is a replication-incompetent (E1 and E3 genes deleted) adenovirus, is used. E1 is essential for the replication of adenovirus. The absence of E1 prevents its self-replication. Its replication depends on packaging cells such as 293A cells, which provide trans-complementary replication for adenovirus. The protein expressed by the E3 gene can resist the host's antiviral defense system, and the removal of the E3 region can reduce the host's immune response. The adenovirus particles provided by Ubigene would be centrifuged and filtered by gradient ultracentrifugation, and the titer would be determined by chitin immunoassay. The titer of adenovirus is in the range of 10 ^ 10 ~ 10 ^ 12pfu / ml.

Product Specs

  Titer Turnaround Application
Standard Size 1*10^10 PFU 3-4weeks Cell transduction
Large size 1*10^11 PFU 3-4weeks Cell transduction
Ultra-purified 1*10^10 PFU 3-4weeks In vivo injection
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AAV Production

Adeno-associated virus (AAV) production
Price on request

Ubigene’s AAV will be purified by ultracentrifugation, and its titer will be determined by qPCR. The titer of AAV ranged from 10^12 to 10^13 v. g. / ml.

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Ubigene’s AAV will be purified by ultracentrifugation, and its titer will be determined by qPCR. The titer of AAV ranged from 10^12 to 10^13 v. g. / ml.

Services Turnaround Deliverable Price (USD)
shRNA 4-6 weeks 1E+12GC 1490
Overexpression 5-7 weeks 1E+12GC 1690

Serotype: Tissues
AAV1: SM,CNS,lung,retina,pancreas,heart,liver
AAV2: SM,SNS,liver,kidney,retina
AAV4: CNS,retina,lung,kidney
AAV5: SM,CNS,lung,retina
AAV6: SM,heart,lung,adipose,liver
AAV7: SM,retina,CNS,liver
AAV8: SM,CNS,retina,liver,pancreas,heart,kidney,adipose
AAV9: SM,lung,liver,heart,pancreas,CNS,retina,testes,kidney
AAVrh10: SM,lung,liver,heart,pancreas,CNS,retina,kidney
AAVPHP.B: CNS
AAVDJ/8: SM, liver, CNS, retina
AAVPHP.S: PNS
AAVPHP.eB: CNS(stronger than AAVPHP.B)

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Lentivirus Production

Price on request

Lentiviral systems have been widely used in various cell lines for gene knockout, overexpression, RNA interference, microRNA related researches and in vivo experiments.

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Lentiviral systems have been widely used in various cell lines for gene knockout, overexpression, RNA interference, microRNA related researches and in vivo experiments.

Services Titer Turnaround Price
gRNA/Cas9 1*10^8 TU 3-4 weeks 559
shRNA 1*10^8 TU 3-4 weeks 559
Overexpression 1*10^8 TU 4-6 weeks 928
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Plasmid Construction

Price on request
Service Turnaround Deliverable Show more »
Service Turnaround Deliverable Price (USD)
gRNA/Cas9 1-2 weeks E. coli stock 80
shRNA 1-2 weeks E. coli stock 80
Overexpression 2 weeks E. coli stock 249

Ubigene offers plasmid construction services for various purposes, including gene knockout, knockin, point mutation, interference, and overexpression.

Validation: Restriction enzyme digestion and sequencing

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Knock-In Cell Lines

Starting at $13,980.00 per cell line

Protein fusion

Replacement of specific locus

CRISPR-U™, developed by Ubigene, is more efficient than general CRISPR/Cas9 in double-strand breaking, and CRISPR-U™ can greatly improve the efficiency of homologous recombination, easily achieve knockout (KO), point mutation (PM) and knockin (KI) in vitro and in vivo.

Protein fusion

Replacement of specific locus

CRISPR-U™, developed by Ubigene, is more efficient than general CRISPR/Cas9 in double-strand breaking, and CRISPR-U™ can greatly improve the efficiency of homologous recombination, easily achieve knockout (KO), point mutation (PM) and knockin (KI) in vitro and in vivo.

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Zebrafish Transgenic Services

Price on request

Ubigene uses Tol2 transposon system to construct transgenic Zebrafish. The transposon system includes transposon and transposase. The target expression frame is located between the two transposons of the expression plasmid. The transposase plasmid is transcribed into mRNA in vitro and co-injected with the expression plasmid.... Show more »

Ubigene uses Tol2 transposon system to construct transgenic Zebrafish. The transposon system includes transposon and transposase. The target expression frame is located between the two transposons of the expression plasmid. The transposase plasmid is transcribed into mRNA in vitro and co-injected with the expression plasmid. The transposase can cut the sequence between the two transposons and paste it into the genome of zebrafish zygote. After genotyping, the individuals with successful integration of target gene will be selected for passage.

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Zebrafish Genome Editing

Price on request

Zebrafish, a tropical freshwater fish, is originally from the Himalayas. Zebrafish is a popular ornamental fish, and it is also an important and widely used model animal in the field of scientific research. 

Ubigene offers Zebrafish gene-editing and transgenic services.

Applications: Drug screening; Disease models; Gene function study.

Zebrafish, a tropical freshwater fish, is originally from the Himalayas. Zebrafish is a popular ornamental fish, and it is also an important and widely used model animal in the field of scientific research. 

Ubigene offers Zebrafish gene-editing and transgenic services.

Applications: Drug screening; Disease models; Gene function study.

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Recombinant Protein Expression

Price on request

Ubigene provides over 2000 recombinant proteins, involving in the following expression systems:

  • Baculovirus
  • E.coli
  • Human Cells
  • P. pastoris
  • P.pichia
  • Yeast

Ubigene provides over 2000 recombinant proteins, involving in the following expression systems:

  • Baculovirus
  • E.coli
  • Human Cells
  • P. pastoris
  • P.pichia
  • Yeast
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Dora Pan

Overseas Marketing
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Jinying Xu

Overseas Marketing

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