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Tumor Imaging Metrics Core

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Boston, Massachusetts, US

About Tumor Imaging Metrics Core

Divison of: Harvard University

The Tumor Imaging Metrics Core (TIMC) provides standardized measurements of radiological scans for oncology clinical trials.

The TIMC's primary services include:
Consultation for protocol design
Image capture of radiological scans from local or remote sites
Quantitative and qualitative measurement of... Show more ยป

The Tumor Imaging Metrics Core (TIMC) provides standardized measurements of radiological scans for oncology clinical trials.

The TIMC's primary services include:
Consultation for protocol design
Image capture of radiological scans from local or remote sites
Quantitative and qualitative measurement of tumors according to trial protocol

TIMC's dedicated and experienced radiology staff is knowledgeable about all tumor types. Images are expertly interpreted from all major imaging modalities, including:
Computed Tomography (CT)
Magnetic Resonance Imaging (MRI)
Positron Emission Tomography (PET), PET/CT, and PET/MRI
X-Rays
Bone Scans

TIMC reviewers are trained and certified in current imaging assessment criteria for oncology clinical trials, including:
RECIST 1.0 and 1.1
WHO
EORTC
Cheson (Original and Revised)
Choi
irRC
PCWG for prostate cancer
Macdonald
Volumetric Assessment

The Tumor Imaging Metrics Core offers web-based order entry and online multi-media results reporting for scan analyses, designed to comply with HIPAA and 21 CFR Part 11 guidelines. Lesions are tracked longitudinally and results are stored in the TIMC database on a secure website accessible by authorized trial staff.

TIMC's streamlined data management process can transfer patient scans:
Via local area network (LAN) from DF/HCC sites to its central lab in DICOM format.
Uploaded from DICOM CD via secure Internet connection from any site.

Quantitative analysis of imaging studies are performed at a variety of modality-specific workstations. After scans are analyzed by TIMC imaging analysts, measurement results are reviewed and finalized by clinically-based Harvard faculty radiologists and/or nuclear medicine physicians.

Turnaround time is generally within 24 hours.

Results are stored in an SQL database and posted on the TIMC secure website where study staff can access annotated images, graphs, and numerical data to show the patient's tumor response. Independent site and central reads are also available.

Since its inception in 2005, TIMC has analyzed more than 60,000 scans for 1000 clinical trials, including 11 disease programs and 7 institutions.

In an anonymous survey, clinical trial staff reported that TIMC's services are fast, accurate, and greatly improve the reliability of tumor response measurement. An in-house study of inter-rater reliability among image analysts resulted in a reliability coefficient of 0.94.

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Our Services (9)


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Clinical Trials, Consulting, and Management

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Bone Scan Image Analysis

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Image Analysis

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CT Image Analysis

Computed tomography image analysis
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Positron Emission Tomography Image Analysis

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Magnetic Resonance Imaging (MRI) Image Processing

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Data Services

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Computational Modeling

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Data Management

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Gina Basinsky

Operations Manager
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Gordon Harris

Co-Director

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