1352590645684 a79d132dd09fb2bf9d53b735ace69c63

Trudeau Institute Contract Research Organization (TICRO)

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Saranac Lake, New York, US

About Trudeau Institute Contract Research Organization (TICRO)

Divison of: Trudeau Institute

TICRO is a full-service contract research organization providing high-quality research project execution to both academic scientists and the biopharmaceutical industry. For nearly 50 years, the Trudeau Institute has been a world-renowned research center with a focus towards understanding the immunological,... Show more »

TICRO is a full-service contract research organization providing high-quality research project execution to both academic scientists and the biopharmaceutical industry. For nearly 50 years, the Trudeau Institute has been a world-renowned research center with a focus towards understanding the immunological, biological and molecular basis of infectious diseases and immune disorders, particularly in the respiratory tract.

TICRO works closely with clients to create the comprehensive study design, management, and execution strategies needed to achieve project objectives with exceptional efficiency. Our highly skilled experts are able to anticipate the challenges of infectious disease research and offer clients creative and personalized project design, while maintaining consistent performance with quality-focused SOPs throughout project execution. Our risk assessment experience, project management insights, established processes, and specialized infrastructure enable us to provide clients with high-quality, cost-effective research project design and execution.

TICRO’s animal models facilitate the evaluation of candidate therapeutics, vaccines and adjuvants for toxic side effects leading to impaired immune cell function and impaired immunity to infections. We offer murine models of infection using a broad range of pathogens, with a focus on respiratory infections, including: Influenza A and B viruses, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Yersinia enterocolitica, Yersinia pestis, Listeria monocytogenes, Campylobacter jejunii, and Francisella tularensis (strain LVS).

TICRO offers specialized expertise and facilities for:
- Immunophenotyping using models of infection and host defense, including murine models of influenza, tuberculosis and pneumonia
- Immunogenicity and immunotoxicology evaluation of candidate therapeutics, vaccines and adjuvants
- Preclinical efficacy testing of antibacterials, antivirals and vaccines with microbiological and clinical endpoints

KEY CAPABILITIES:
- Mouse models of infection with a broad range of pathogens, including many that target the respiratory tract
- Animal facilities and technical services, including bio-safety level 2 and 3 suites with select agent capabilities, surgery, rederivation, cryopreservation, breeding and aging
- Flow cytometry services, including design and execution of multi-parameter phenotyping of low frequency cells and isolation of specific cell populations from infected samples
- Microscopy and imaging services including advanced histology, immunohistochemistry, immunofluorescence, and imaging
- Molecular biology services, including investigations of the impact of candidate therapeutics, infectious disease, vaccines, and adjuvants on immune cell function at the molecular and gene expression levels
- Microscopy and imaging services including advanced histology, immunohistochemistry, immunofluorescence, and imaging

Certifications: BSL-2, BSL-3

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Certifications & Qualifications

BSL-2 BSL-3

Our Services (101)


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Influenza Animal Models

Price on request
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ADCC and CDC Assays

Price on request

Vaccine/infection-induced antibody responses
Neutralizing antibody assays

Vaccine/infection-induced antibody responses
Neutralizing antibody assays

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Animal Husbandry

Price on request

Animal models facilitate the study of the pathogenesis and complications of infectious disease, as well as allowing for the evaluation of treatment protocols that are not immediately feasible or ethical in human patients. Murine models provide populations of genetically uniform subjects that can be maintained under environmentally... Show more »

Animal models facilitate the study of the pathogenesis and complications of infectious disease, as well as allowing for the evaluation of treatment protocols that are not immediately feasible or ethical in human patients. Murine models provide populations of genetically uniform subjects that can be maintained under environmentally controlled conditions. Initial in vivo testing of new pharmaceutical agents in mouse models allows for critical early stage evaluation of potential toxicity and unexpected side effects of therapeutics prior to human application.

Our Animal Facilities and Technical Services Core offer the following services:

• Animal bio-safety level 2 and 3 suites
• Aerosol exposure and select agent capabilities
• Complex mouse surgery
• Production of hematopoietic chimeras
• Mouse rederivation and cryopreservation
• Contract breeding
• Mouse aging services

All animals are housed in individually ventilated micro isolator cages. More than 95 percent of the mice used each year are bred on site in the mouse breeding facility, which houses more than 100 inbred, congenic, transgenic, and mutant strains. A comprehensive sentinel monitoring program is in place for all animal facilities.

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Animal Surgery

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Antigen Expression and Purification

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Custom antigen-specific cell detection

Custom antigen-specific cell detection

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Bacterial Infection Animal Models

Price on request

Mouse models of infection with a broad range of pathogens, including many that target the respiratory tract including:

Influenza A and B viruses, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Yersinia enterocolitica, Yersinia pestis, Listeria... Show more »

Mouse models of infection with a broad range of pathogens, including many that target the respiratory tract including:

Influenza A and B viruses, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Yersinia enterocolitica, Yersinia pestis, Listeria monocytogenes, Campylobacter jejunii, and Francisella tularensis (strain LVS). We have the scientific expertise to tailor these models to client specifications and develop new infectious disease models to meet the needs of clients.

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Complete Blood Count

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Cryosectioning

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Cytokine Analysis

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ELISA, Luminex array, ELISPOT, intracellular cytokine staining,

ELISA, Luminex array, ELISPOT, intracellular cytokine staining,

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Drug Absorption Studies

Price on request

There is an ever-growing demand for vaccines and therapeutics that can effectively prevent or treat a wide range of infectious diseases. Preclinical efficacy testing determines the efficacy of vaccine and therapeutic candidates and provides insights into dose and dose scheduling.

TICRO scientists have established expertise with... Show more »

There is an ever-growing demand for vaccines and therapeutics that can effectively prevent or treat a wide range of infectious diseases. Preclinical efficacy testing determines the efficacy of vaccine and therapeutic candidates and provides insights into dose and dose scheduling.

TICRO scientists have established expertise with in vivo infectious disease models. We offer a broad spectrum of established infection models to assess preclinical efficacy of vaccine candidates in challenge studies and anti-infective agents. We offer murine models of infection using a broad range of pathogens, with a focus on respiratory infections, including: Influenza A and B viruses, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Yersinia enterocolitica, Yersinia pestis, Listeria monocytogenes, Campylobacter jejunii, and Francisella tularensis (strain LVS). We have the scientific expertise to tailor these models to client specifications and develop new infectious disease models to meet the needs of clients.

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ELISA

Enzyme-linked immunosorbent assay
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FACS

Fluorescence Activated Cell Sorting
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Flow Cytometry

Price on request

14-color/16-parameter BD LSRII flow cytometry for analysis of low frequency cells

11-color/13-parameter BD Influx with BSL2+ biocontainment for viable cell separation of infected samples

8-color BD FACSCanto II flow cytometry for multi-parameter analysis for complex cell phenotyping

4-color BDFACSCaliburs and 3-color... Show more »

14-color/16-parameter BD LSRII flow cytometry for analysis of low frequency cells

11-color/13-parameter BD Influx with BSL2+ biocontainment for viable cell separation of infected samples

8-color BD FACSCanto II flow cytometry for multi-parameter analysis for complex cell phenotyping

4-color BDFACSCaliburs and 3-color BDFACScans for high throughput flow cytometry sample screening

Multicolor immunofluorescent panel design assistance

Flow cytometry experiment and protocol design and sample preparation assistance

Acquisition and analysis of flow cytometric data

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Flow Cytometry Data acquisition

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Flow Cytometry Data Analysis

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Immunofluorescence

Price on request

5-color immunofluorescence with laser scanning confocal microscopy and imaging

5-color immunofluorescence with laser scanning confocal microscopy and imaging

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Immunohistochemistry (IHC)

Price on request

Immunohistochemistry for pathogen, epithelial cell and immune cell markers

Immunohistochemistry for pathogen, epithelial cell and immune cell markers

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Immunophenotyping

Price on request

Evaluation of effects on immune function is an essential component of when evaluating the safety of new drugs and biotechnology products. Changes in immunity may alter the desired clinical effects of drugs, and some therapeutic agents may increase susceptibility to infectious diseases.

Animal models facilitate the study of the... Show more »

Evaluation of effects on immune function is an essential component of when evaluating the safety of new drugs and biotechnology products. Changes in immunity may alter the desired clinical effects of drugs, and some therapeutic agents may increase susceptibility to infectious diseases.

Animal models facilitate the study of the pathogenesis and complications of diseases. They permit the evaluation of treatment protocols that are not immediately feasible or ethical in human patients. Animal models of infection provide populations of genetically uniform subjects that can be maintained under environmentally controlled conditions.

TICRO offers an immunology and immunophenotyping program tailored to the needs of both academic researchers and the biopharmaceutical industry. We also offer in vivo assessment of immune cell phenotype and immune cell function in response to drug administration in the context of in vivo murine models of vaccination and infectious disease.

Immunology and immunophenotyping can be assessed using in vivo and in vitro assays of immune function. The following assays are currently available, and custom assays can be developed according to customer specifications:
• Complete blood count, differential white blood cell count
• Lymphoid organ weights, body weight and temperature
• Histopathology, gross and microscopic
• ELISA
• T-Cell phenotype and function
• B-Cell phenotype and function
• Cytokine quantitation
• Cytotoxicity assays
• Vaccine/infection-induced antibody responses
• Neutralizing antibody assays
• Pathogen burden quantitation
• Flow cytometry
• Immunohistochemistry
• Molecular biology assays

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Viral Infection Animal Models

Price on request

TICRO’s animal models facilitate the evaluation of candidate therapeutics, vaccines and adjuvants for toxic side effects leading to impaired immune cell function and impaired immunity to infections. We offer murine models of infection using a broad range of pathogens, with a focus on respiratory infections, including: Influenza A... Show more »

TICRO’s animal models facilitate the evaluation of candidate therapeutics, vaccines and adjuvants for toxic side effects leading to impaired immune cell function and impaired immunity to infections. We offer murine models of infection using a broad range of pathogens, with a focus on respiratory infections, including: Influenza A and B viruses, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Yersinia enterocolitica, Yersinia pestis, Listeria monocytogenes, Campylobacter jejunii, and Francisella tularensis (strain LVS).

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Mouse Influenza

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Molecular Cloning

Price on request

Custom gain of function (over-expression) and loss of function (shRNA) retroviral constructs and retrovirus production

Custom gain of function (over-expression) and loss of function (shRNA) retroviral constructs and retrovirus production

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Rodent Rederivation

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Mouse

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Animal Organ Harvesting

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Paraffin Embedding

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In vivo PK/PD Studies

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Pneumonia Animal Models

Price on request

Immunophenotyping

TICRO offers an immunology and immunophenotyping program tailored to the needs of both academic researchers and the biopharmaceutical industry. We also offer in vivo assessment of immune cell phenotype and immune cell function in response to drug administration in the context of in vivo murine models of... Show more »

Immunophenotyping

TICRO offers an immunology and immunophenotyping program tailored to the needs of both academic researchers and the biopharmaceutical industry. We also offer in vivo assessment of immune cell phenotype and immune cell function in response to drug administration in the context of in vivo murine models of vaccination and infectious disease.

Immunology and immunophenotyping can be assessed using in vivo and in vitro assays of immune function. The following assays are currently available, and custom assays can be developed according to customer specifications:
- Complete blood count, differential white blood cell count
- Lymphoid organ weights, body weight and temperature
- Histopathology, gross and microscopic
- ELISA
- T-Cell phenotype and function
- B-Cell phenotype and function
- Cytokine quantitation
- Cytotoxicity assays
- Vaccine/infection-induced antibody responses
- Neutralizing antibody assays
- Pathogen burden quantitation
- Flow cytometry
- Immunohistochemistry
- Molecular biology assays

TICRO’s animal models facilitate the evaluation of candidate therapeutics, vaccines and adjuvants for toxic side effects leading to impaired immune cell function and impaired immunity to infections. We offer murine models of infection using a broad range of pathogens, with a focus on respiratory infections, including: Influenza A and B viruses, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Yersinia enterocolitica, Yersinia pestis, Listeria monocytogenes, Campylobacter jejunii, and Francisella tularensis (strain LVS).

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RNA Extraction and Purification

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Recombinant Protein Expression

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Retroviral Production

Price on request

Custom gain of function (over-expression) and loss of function (shRNA) retroviral constructs and retrovirus production

Custom gain of function (over-expression) and loss of function (shRNA) retroviral constructs and retrovirus production

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Paraffin Sectioning

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Veterinary Pathology

Price on request

Lymphoid organ weights, body weight and temperature

Lymphoid organ weights, body weight and temperature

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Special Slide Staining

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Routine and specialty staining of tissue sections

Routine and specialty staining of tissue sections

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Temperature Measurement

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Tissue Preparation

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Processing tissues for paraffin and cryosectioning

Processing tissues for paraffin and cryosectioning

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Genetically Engineered Mice

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Tuberculosis Animal Models

Price on request

Immunophenotyping

TICRO offers an immunology and immunophenotyping program tailored to the needs of both academic researchers and the biopharmaceutical industry. We also offer in vivo assessment of immune cell phenotype and immune cell function in response to drug administration in the context of in vivo murine models of... Show more »

Immunophenotyping

TICRO offers an immunology and immunophenotyping program tailored to the needs of both academic researchers and the biopharmaceutical industry. We also offer in vivo assessment of immune cell phenotype and immune cell function in response to drug administration in the context of in vivo murine models of vaccination and infectious disease.

Immunology and immunophenotyping can be assessed using in vivo and in vitro assays of immune function. The following assays are currently available, and custom assays can be developed according to customer specifications:
- Complete blood count, differential white blood cell count
- Lymphoid organ weights, body weight and temperature
- Histopathology, gross and microscopic
- ELISA
- T-Cell phenotype and function
- B-Cell phenotype and function
- Cytokine quantitation
- Cytotoxicity assays
- Vaccine/infection-induced antibody responses
- Neutralizing antibody assays
- Pathogen burden quantitation
- Flow cytometry
- Immunohistochemistry
- Molecular biology assays

TICRO’s animal models facilitate the evaluation of candidate therapeutics, vaccines and adjuvants for toxic side effects leading to impaired immune cell function and impaired immunity to infections. We offer murine models of infection using a broad range of pathogens, with a focus on respiratory infections, including: Influenza A and B viruses, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Yersinia enterocolitica, Yersinia pestis, Listeria monocytogenes, Campylobacter jejunii, and Francisella tularensis (strain LVS).

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Widefield Fluorescence Microscopy

Price on request

Wide-field imaging in both bright-field and fluorescence

Wide-field imaging in both bright-field and fluorescence

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Human Tumor Xenograft Models

Price on request

TICRO’s animal models facilitate the evaluation of candidate therapeutics, vaccines and adjuvants for toxic side effects leading to impaired immune cell function and impaired immunity to infections. We offer murine models of infection using a broad range of pathogens, with a focus on respiratory infections, including: Influenza A... Show more »

TICRO’s animal models facilitate the evaluation of candidate therapeutics, vaccines and adjuvants for toxic side effects leading to impaired immune cell function and impaired immunity to infections. We offer murine models of infection using a broad range of pathogens, with a focus on respiratory infections, including: Influenza A and B viruses, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Yersinia enterocolitica, Yersinia pestis, Listeria monocytogenes, Campylobacter jejunii, and Francisella tularensis (strain LVS).

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cDNA Synthesis

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qPCR

Quantitative PCR
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Biospecimens

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Computational Modeling

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RNA Services

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Virus Production

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Animal Physiology Analyses

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Microbiology

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Imaging & Spectroscopy

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Fluorescence-Based Microscopy

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Toxicology

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Xenograft Models

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Protein Production

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Tissue Processing

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Biospecimen Management and Storage

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Clinical Laboratory Services

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Clinical Research

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Animal Models of Disease

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Blood Count

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DNA Synthesis and Probe Development

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Animal Model Housing and Maintenance

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Transgenic Animal Model Development

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Biochemistry & Molecular Biology

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Cryostorage and Cryoprocessing

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Cytotoxicity Assays

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Data Services

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Respiratory Disease Animal Models

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Animal Model in vivo Analyses

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Sequencing data in FASTQ

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Cells and Tissues

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Cytometry

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Protein Quantification

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Pharmacology & Toxicology

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Biomarkers

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Histological Staining

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Animal Models and Studies

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Cryopreservation

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Optical Microscopy

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Transgenic Mouse Services

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Virology Services

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Protein Expression Visualization

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Infectious Disease Animal Models

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Antibody Services

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Immunostaining

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Protein Services

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Veterinary Research & Diagnostics

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Nucleic Acid Services

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Bioanalysis

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Oncology Animal Models

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Discovery Pathology

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Tissue Embedding

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Physical Analysis Methods

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Microscopy

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PCR

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Thermal Analysis Services

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Genetic Engineering

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DNA Services

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Engineering and Fabrication

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Veterinary Laboratory Services

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Clinical Hematology

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Tissue Sectioning

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Immunoassays

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Clinical and Anatomic Pathology

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