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Translational Pathology Laboratory (TPL)

Chapel Hill, North Carolina, US

The Translational Pathology Laboratory (TPL) is a core facility in the UNC School of Medicine administered by the Lineberger Comprehensive Cancer Center and the Department of Pathology and Laboratory Medicine. We offer access to sophisticated digital pathology platforms and study design support to all UNC investigators to enhance translational research.

Recent Publications

  • Karginova O, Siegel MB, Van Swearingen AE, Deal AM, Adamo B, Sambade MJ, et al. Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer. Mol Cancer Ther. 2015;14(4):920-30. Epub 2015/04/01. doi: 10.1158/1535-7163.MCT-14-0474. PubMed PMID: 25824335; PubMed Central PMCID: PMC4394032.
  • Chang EHea. Palladin is Upregulated in Kidney Disease and Contributes to Epithelial Cell Migration After Injury. Sci Rep. 2015;5(7695).
  • Carson CC,... Show more »

The Translational Pathology Laboratory (TPL) is a core facility in the UNC School of Medicine administered by the Lineberger Comprehensive Cancer Center and the Department of Pathology and Laboratory Medicine. We offer access to sophisticated digital pathology platforms and study design support to all UNC investigators to enhance translational research.

Recent Publications

  • Karginova O, Siegel MB, Van Swearingen AE, Deal AM, Adamo B, Sambade MJ, et al. Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer. Mol Cancer Ther. 2015;14(4):920-30. Epub 2015/04/01. doi: 10.1158/1535-7163.MCT-14-0474. PubMed PMID: 25824335; PubMed Central PMCID: PMC4394032.
  • Chang EHea. Palladin is Upregulated in Kidney Disease and Contributes to Epithelial Cell Migration After Injury. Sci Rep. 2015;5(7695).
  • Carson CC, Moschos SJ, Edmiston SN, Darr DB, Nikolaishvili-Feinberg N, Groben PA, et al. IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma. Clin Cancer Res. 2015;21(9):2167-76. Epub 2015/05/03. doi: 10.1158/1078-0432.CCR-14-1826. PubMed PMID: 25934889; PubMed Central PMCID: PMC4418029.
  • Zhou B, Damrauer JS, Bailey ST, Hadzic T, Jeong Y, Clark K, et al. Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal. J Clin Invest. 2014;124(2):553-63. Epub 2014/01/18. doi: 10.1172/JCI69804. PubMed PMID: 24435044; PubMed Central PMCID: PMC3904607.
  • Zhang L YH, Burk LM, Inscoe CR, Hadsell MJ, Chtcheprov P, Lee YZ, Lu J, Chang S, Zhou O. Image-guided microbeam irradiation to brain tumour bearing mice using a carbon nanotube x-ray source array. Phys Med Biol. 2014;59:1283-303. PubMed Central PMCID: PMCPMC4028041.
  • Wyss AB WM, Avery CL, Herring AH, Bensen JT, Barnholtz-Sloan JS, Funkhouser WK, Olshan AF. Single nucleotide polymorphisms in nucleotide excision repair genes, Cancer Treatment, and the Head and Neck Cancer Survival. Cancer Causes & Control 2014;25:437, 2014. PubMed Central PMCID: PMC PMC4096829.
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Immunofluorescence
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Immunohistochemistry (IHC)
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