Translational Mouse Model Core Facility

Translational mouse models of human disease are very important tools that serve as a bridge between basic research and clinical application. Over the last several years the field of humanized mice has matured and developed into an essential component of translational research. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research.

The Core will provide humanized mouse models to the researchers at UNMC and also at other institutions around the nation, in the form of collaborations.

For any pilot projects or for grant applications involving humanized mice, contact us for free consultations to discuss and develop the experimental plan. We will also help with the budget and preparing the subcontract for grant application.

Selected Publications

1: Araínga M, Su H, Poluektova LY, Gorantla S, Gendelman HE. HIV-1 cellular and tissue replication patterns in infected humanized mice. Sci Rep. 2016 Mar 21;6:23513. doi: 10.1038/srep23513. PubMed PMID: 26996968; PubMed Central PMCID: PMC4800734.
2: Zhang G, Guo D, Dash PK, Araínga M, Wiederin JL, Haverland NA, Knibbe-Hollinger J, Martinez-Skinner A, Ciborowski P, Goodfellow VS, Wysocki TA, Wysocki BJ, Poluektova LY, Liu XM, McMillan JM, Gorantla S, Gelbard HA, Gendelman
HE. The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy. Nanomedicine. 2016 Jan;12(1):109-22. doi: 10.1016/j.nano.2015.09.009. PubMed PMID: 26472049; PubMed Central PMCID: PMC4728028.
3: Boska MD, Dash PK, Knibbe J, Epstein AA, Akhter SP, Fields N, High R, Makarov E, Bonasera S, Gelbard HA, Poluektova LY, Gendelman HE, Gorantla S. Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice. Mol Neurodegener. 2014 Dec 18;9:58. doi:10.1186/1750-1326-9-58. PubMed PMID: 25523827; PubMed Central PMCID: PMC4297430.
4: Gutti TL, Knibbe JS, Makarov E, Zhang J, Yannam GR, Gorantla S, Sun Y, Mercer DF, Suemizu H, Wisecarver JL, Osna NA, Bronich TK, Poluektova LY. Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned
uPA-NOG mice. Am J Pathol. 2014 Jan;184(1):101-9. doi: 10.1016/j.ajpath.2013.09.008. PubMed PMID: 24200850; PubMed Central PMCID: PMC3873481.