Here at the Christchurch Heart Institute we help save thousands of lives and increase survival of those suffering from heart disease, through research into improved diagnosis, better prediction and advanced treatments.
Our research is focussed on
At the Translational Biodiscovery Lab, we focus on the development of novel biomarker assays for the diagnosis and prognosis of disease, in both clinical and pre-clinical settings. Most assays have been developed to detect the human, rodent and ovine forms of these hormones. In addition, HPLC technology is employed to assess the kinetics and mechanisms underlying the metabolism of peptides in plasma and tissue. The lab is well equipped with high-throughput Roche and BRAHMS Kryptor analysers, as well as RIA, ELISA and Luminex technologies. We also have in vitro cell culture and ex vivo isolated heart facilities for further biodiscovery applications.
Cardiovascular biomarker research measurement and biochemical analysis of over 30 different important markers (including troponins, BNP/ANP/CNP peptides, neprilysin activity, endothelins, angiotensin, catecholamines) and more. All assays are quality controlled to ISO15189-like standard and we have undertaken contracts for multiple research and industry providers.
Assays that have been developed within the laboratory include;
Biochemical characterisation of targets can be carried out using reverse phase, size exclusion and ion exchange HPLC modalities. Mass spectroscopy analysis to augment results can also be arranged.
In house multiplex assays to differential BNP peptide forms and singleplex for CNP peptides are available. In house assays for ANP peptides are in development. Externally provided cytokine, growth factor and cardiovascular markers are available on request.
A full suite of tissue and plasma ELISAs are available for cardiovascular, metabolic, immunology and emergency medicine studies in clinical and experimental settings.
Protein Purification and Quantification Services
Translational Biodiscovery Lab, Christchurch Heart Institute has not received any reviews.
Translational Biodiscovery Lab, Christchurch Heart Institute has not received any endorsements.