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Toxys

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Leiden, NL

About Toxys

Toxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development. We aim to bring information to our customers that is essential to make... Show more »

Toxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development. We aim to bring information to our customers that is essential to make informed decisions on which compounds to progress in the drug/compound development pipeline, thereby contributing to the development of better medicines and products and to reduce animal testing.

Toxicity is a major reason why compounds fail in drug or product development. Being able to quickly and accurately identifying toxic compounds and prevent incorrect labeling as toxic is important to reduce late stage attrition. Current toxicity assays have various downsides; they are low in sensitivity and specificity and fail to provide mechanistic insight. The consequences are unnecessary investment in hazardous compounds, loss of high potential lead compounds and needless animal testing. We offer assays which helps to identify toxic compounds quickly and accurately, and prevents incorrect labelling as toxic.

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Our Services (3)


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In vitro Genotoxicity Testing

Price on request

ToxTracker Assay - For Understanding Mode-of-Action in Genotoxicity
ToxTracker is an unique genotoxicity assay that combines multiple biomarkers to gain mechanistic insight into the of action of genotoxic compounds. The assay not only includes markers for DNA damage as predictors for standard genotoxicity assays, but also... Show more »

ToxTracker Assay - For Understanding Mode-of-Action in Genotoxicity
ToxTracker is an unique genotoxicity assay that combines multiple biomarkers to gain mechanistic insight into the of action of genotoxic compounds. The assay not only includes markers for DNA damage as predictors for standard genotoxicity assays, but also includes markers for non-genotoxic MOA, including oxidative stress, protein misfolding and general cellular stress. All these types of cellular damage have been associated with increased cancer risk. The assay is currently being used by various of the top 10 pharma, chemistry and cosmetics companies.

Key features
• Unique genotocicity screening platform
• stem-cell based in vitro assay for mechanistic toxicity testing
• Unsurpassed sensitivity and specificity
• Excellent correlation with regulatory assays

Unique biomarkers
The ToxTracker assays consist of 6 reporter cell lines which are developed for unique biomarkers that discriminate between induction of DNA damage, oxidative stress, protein damage and general cellular stress.

Extensively validated
The assays is extensively validated, over 450 compounds have been tested, including a selection of compounds form the ECVAM library and Toxcast library and various types of customer compounds. The ToxTracker assay showed a very high sensitivity (94%) and specificity (95%) for the detection of genotoxic compounds and has a strong correlation with the regulatory assays.

Delivered Results
• Extensive cytotoxicity profile
• Assessment of mechanism of toxicity
• EC 10/25/50 and LC 10/25/50
• Toxicity profile ± metabolising system
• Comparison of ToxTracker profile to reference compounds

Sample requirements
To be discussed, depending on substance type/purpose.
15/150 mg supplied as dry powder or dissolved in H2O/DMSO.

Turnaround time
Typically 2-3 weeks upon receiving test compound.
Express service for delivery within 3 days possible.

More information on ToxTracker Assay
https://toxys.com/services/genetic-toxicology-assays/toxtracker/
https://www.youtube.com/watch?v=fmR82YMNSjU

ToxTracker ACE
ToxTracker ACE (Aneugen Clastogen Evaluation) is an extended version of ToxTracker assay and includes direct discrimination between an aneugenic and a clastogenic mode-of-action of genotoxic compounds.
https://toxys.com/services/genetic-toxicology-assays/toxtrackerace/

ToxTracker MoA extensions
We have developed several extensions to the standard ToxTracker protocol that can be applied to further assess the underlying mode-of-action of toxic compounds. We can address a.o. separating clastogens from aneugens, identification of kinase inhibitors and the contribution of oxidate stress by introducing ROS scavengers.
https://toxys.com/services/genetic-toxicology-assays/toxtracker-plus/

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Nanoparticles Compounds agrochemicals milligram Toxicology Environmental Science Small Molecule Drugs Show 7 more tags Show less

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In vitro Toxicity Testing

Price on request

Kindly view our offer within In vitro genotoxicity testing for a detailed description of our ToxTracker assay and related services.

Kindly view our offer within In vitro genotoxicity testing for a detailed description of our ToxTracker assay and related services.

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Toxicology

Price on request

Kindly view our offer within In vitro genotoxicity testing for a detailed description of our ToxTracker assay and related services.

Kindly view our offer within In vitro genotoxicity testing for a detailed description of our ToxTracker assay and related services.

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ToxTracker ACE Factsheet.pdf

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ToxTracker Factsheet-share.pdf

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ToxTracker MoA Extensions-share.pdf

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