Tissue Solutions is a virtual biobank, sourcing ethically acquired, fully consented tissue from our extensive global network of more than 150 sources. Our collaborating partners include direct hospital sources, commercial biobanks as well as prospective post—mortem organ and tissue collection agencies. One of the advantages of working with us is that we can widen our scope to include multiple storage facilities, thus allowing us to meet stringent requirements and tight deadlines more efficiently, and to supply a greater variety of tissues than a single biobank; Because our tissue service is a customised approach we are not restricted to a specific disease area in the types of tissue we are most likely to source. Every source in our network has the required ethics or institutional review board (IRB) approvals in place, and we ensure that we have copies of this and their patient consent forms. Copies of our sources’ IRB / Ethics approval and template donor consent forms are available on request. As part of our ISO 9001:2015 certification, we guarantee the quality of our samples, and continually review our suppliers for their product and service provision.
Our Tissue Procurement Team is extremely experienced in efficient and ethical prospective collection of human specimens for research.
Ante— and Post—Mortem Tissue Collections
Feasibility Studies
Our specialist tissue aquisitionists have more than 30 years of experience in sourcing human tissue for research. Our feasibility studies include the following:
All contact details of those potentially involved, and a brief description of their role, would be provided.
Establishing Clinical Collaborations
We are able to establish direct agreements between you and the human tissue source if required. For prospective collections we can prepare the project plan, recruit collaborating clinicians, and secure an agreement with the source, all on your behalf.
Obtaining UK Ethical Approval
For our clients in the UK, we also offer advice on the ethics application process. This can include:
Human Sample Transport Logistics
We coordinate tissue delivery direct from the source to you and deal with all logistics and paperwork, including expediting materials through customs in cross—border deliveries. We can implement logistics programmes anywhere in the world for efficient transport, and guarantee the maintenance of sample integrity whether it is banked or fresh, chilled or frozen.
Our experienced logistics team review transit requirements for each project and ship using validated packaging with the most appropriate courier. We work with a number of specialist couriers worldwide and continually review their performance.
We provide a range of fresh human tissue samples to our clients in the UK, Europe and USA on a prospective basis. The viability of this will obviously vary depending on the locations of both the source and the client.
We can deliver a range of both normal and cancer samples from surgical resection for use in for example ex vivo and cell based assays.
Fresh Tissue | Normal | Cancer |
---|---|---|
Bloods | x | x |
Urine | x | x |
Skin | x | |
Breast | x | x |
Colon | x | x |
Kidney | x | x |
Lung | x | x |
Bladder | x | x |
Pancreas | x | x |
Ovarian | x | |
Head & Neck | x | x |
Prostate | x |
In addition, post mortem samples can be provided from organ donors that are not suitable for transplantation.
Fresh bloods and urine samples can also be obtained from healthy and diseased volunteers on a prospective collection basis.
Fresh human skin is available for use in your drug discovery and development applications such as drug permeation studies, skin irritation and toxicology models and for the isolation of primary and stem cells.
We provide surgical excess tissue following cosmetic procedures and can supply sheets of fresh skin from abdomen (full thickness and dermatomed), breast, scalp, and occasionally from arm, upper and lower eye lid and back.
Post mortem skin can also be obtained from most areas of the body (depending on donor consent) and the typical post mortem intervals (PMIs) are 6-8 hours. The donor age range does vary but donors over the age of 65 will be more common.
All fresh skin samples can be shipped in your medium of choice and are supplied with details of the donors HCV, HBV and HIV status.
Cryopreserved human PBMCs and Cord Blood Mononuclear Cells are now available immediately, with functionality comparable to fresh isolations. We also offer highly purified monocyte, T-cells and B-cell subsets. These are available with basic or enhanced Characterization.
PBMCs available from normal and diseased donors (includes autoimmune diseases: RA, SLE,
Crohn’s, MS)
Basic Characterization — includes age, gender, ethnicity, HLA-I data
Enhanced Characterization — includes age, gender, ethnicity, HLA Class-I and Class-II data and ELISpot-IFNγ responses to PHA, CEF and CMV peptide pools
All cells are supplied with donor information including age, sex, liver pathology and medical history. We can also supply subcellular fractions: microsomes, S9 fractions (non—induced or induced and cytosols).
We are continually adding to our range of cells isolated from fresh human tissue. These are a valuable, physiologically relevant in vitro research tool. We can offer:
These can be shipped as live cultures or cryopreserved.
Hepatocytes:
All cells are supplied with donor information including age, sex, liver pathology and medical history. We can also supply subcellular fractions: microsomes, S9 fractions (non—induced or induced and cytosols).
Peripheral Blood Mononuclear Cells (PBMC):
Cryopreserved human PBMCs and Cord Blood Mononuclear Cells are now available immediately, with functionality comparable to fresh isolations. We also offer highly purified monocyte, T-cells and B-cell subsets. These are available with basic or enhanced Characterization.
All cells are supplied with donor information including age, sex, liver pathology and medical history. We can also supply subcellular fractions: microsomes, S9 fractions (non—induced or induced and cytosols).
Human Keratinocytes:
Normal adult keratinocytes prepared from breast or abdominal skin.
Human Fibroblasts:
Isolated from abdominal skin, breast skin or scalp samples.
Human Melanocytes:
Epidermal melanocytes isolated from the skin of healthy donors.
Human Adipocytes & Pre—adipocytes:
Subcutaneous adipocytes and pre—adipocytes purified from surgical excess normal material. Protocols for culture and differentiation are provided.
Human Pancreatic Islets:
High quality, characterised human pancreatic islets are available for research use, including normal human islets and pancreatic islets from type 1 and type 2 diabetic donors.
All our human cells have been isolated from donors that are negative for HIV1/2, HCV and HBV infection and certified free of mycoplasmal, bacterial, yeast and fungal contamination. Please contact us for details of our current stock availability.
Cryopreserved human PBMCs and Cord Blood Mononuclear Cells are now available immediately, with functionality comparable to fresh isolations. We also offer highly purified monocyte, T-cells and B-cell subsets. These are available with basic or enhanced Characterization.
All cells are supplied with donor information including age, sex, liver pathology and medical history. We can also supply subcellular fractions: microsomes, S9 fractions (non—induced or induced and cytosols).
Cell and Tissue Culture Services
Human Tissue Services
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