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Timur Yarovinsky, MD, PhD

Woodbridge, Connecticut, US

More than 20 years of biomedical research experience in academic settings. Consulting biomedical startup companies and providers of biomedical supplies, equipment and software.

Education & Training:

PhD - Russian State Medical University Moscow (1996)
MD - Russian State Medical University (Moscow) (1994)
Postdoctoral Fellow - The University of Iowa

Selected Publications:

Phospholipid scramblase 1 mediates type i interferon-induced protection against staphylococcal α-toxin. Lizak M, Yarovinsky TO. Cell Host Microbe. 2012 Jan 19;11(1):70-80. doi: 10.1016/j.chom.2011.12.004. PMID: 22264514

Macrophage β2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis. Zhang J, Modi Y, Yarovinsky T, Yu J, Collinge M, Kyriakides T, Zhu Y, Sessa WC, Pardi R, Bender JR. Am J Pathol. 2012 Apr;180(4):1751-60. doi: 10.1016/j.ajpath.2011.12.025. Epub... Show more »

More than 20 years of biomedical research experience in academic settings. Consulting biomedical startup companies and providers of biomedical supplies, equipment and software.

Education & Training:

PhD - Russian State Medical University Moscow (1996)
MD - Russian State Medical University (Moscow) (1994)
Postdoctoral Fellow - The University of Iowa

Selected Publications:

Phospholipid scramblase 1 mediates type i interferon-induced protection against staphylococcal α-toxin. Lizak M, Yarovinsky TO. Cell Host Microbe. 2012 Jan 19;11(1):70-80. doi: 10.1016/j.chom.2011.12.004. PMID: 22264514

Macrophage β2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis. Zhang J, Modi Y, Yarovinsky T, Yu J, Collinge M, Kyriakides T, Zhu Y, Sessa WC, Pardi R, Bender JR. Am J Pathol. 2012 Apr;180(4):1751-60. doi: 10.1016/j.ajpath.2011.12.025. Epub 2012 Feb 7. PMID: 22322302

Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR.
J Exp Med. 2014 Sep 22;211(10):1957-68. doi: 10.1084/jem.20132130. Epub 2014 Sep 1.
PMID: 25180062

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Reagent Evaluation
Starting at $80.00 per hour

We will gladly evaluate novel research reagents and software. We will provide written report with specific comments on pros and cons along with suggestions for improvements.We have previously provided beta testing for LI-COR, Promega, and Corning.

We will gladly evaluate novel research reagents and software. We will provide written report with specific comments on pros and cons along with suggestions for improvements.We have previously provided beta testing for LI-COR, Promega, and Corning.

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ATP Release Assay
Starting at $7.00 per sample

Kinetic and endpoint assay for extracellular ATP release from cultured cells with the sensitivity at low nM range.
Many cells release their ATP into extracellular space in response to various triggers, such as microbial toxins, mechanical stimulation, apoptosis, etc. Extracellular ATP (eATP) and its metabolites have profound... Show more »

Kinetic and endpoint assay for extracellular ATP release from cultured cells with the sensitivity at low nM range.
Many cells release their ATP into extracellular space in response to various triggers, such as microbial toxins, mechanical stimulation, apoptosis, etc. Extracellular ATP (eATP) and its metabolites have profound effects on migration and activation of leukocytes, inflammation, and epithelial and endothelial barriers during infection. Using a luminescence-based assay we can measure eATP in real time for kinetic studies or at predetermined time points. We have shown eATP release from human lung epithelial cells after exposure to a pore-forming toxin from S. aureus (Lizak & Yarovinsky, Cell Host Microbe. 2012 Jan 19; 11(1): 70–80).

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Bacterial Infection Animal Models
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  • Staphylococcal infection mouse model (pneumonia, sepsis) using laboratory and clinical isolates; price on request.

  • Endotoxemia or sterile inflammation; price on request.

  • Liver acute phase response; price on request.

  • Staphylococcal infection mouse model (pneumonia, sepsis) using laboratory and clinical isolates; price on request.

  • Endotoxemia or sterile inflammation; price on request.

  • Liver acute phase response; price on request.

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Using luminescent or fluorescent-based assay, we can measure viability of suspension or adherent cultured cells at different time points after treatment.

Using luminescent or fluorescent-based assay, we can measure viability of suspension or adherent cultured cells at different time points after treatment.

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T Cell Activation and Proliferation Assays
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T cell proliferation (CFSE) in vitro. Prices from $15 per sample.

T cell proliferation (CFSE) in vitro. Prices from $15 per sample.

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Flow cytometry analyses (surface and intracellular) and phenotyping of T cells; prices from $45 per sample.

Flow cytometry analyses (surface and intracellular) and phenotyping of T cells; prices from $45 per sample.

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Phagocytosis Assay
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Apoptosis Assays
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Research project management (experimental design, response to reviews, progress reports); from $80 per hour.

Research project management (experimental design, response to reviews, progress reports); from $80 per hour.

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Dissertation, Thesis and Proposal Editing
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Confidential review and editing of manuscripts, dissertations and grant applications; from $80 per hour.

Confidential review and editing of manuscripts, dissertations and grant applications; from $80 per hour.

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Scientific Manuscript Editing
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Animal protocol writing, editing, submission to IACUC, review; from $80 per hour.

Animal protocol writing, editing, submission to IACUC, review; from $80 per hour.

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User Acceptance Testing
Starting at $80.00 per hour

We will gladly evaluate novel research reagents and software. We will provide written report with specific comments on pros and cons along with suggestions for improvements.We have previously provided beta testing for LI-COR, Promega, and Corning.

We will gladly evaluate novel research reagents and software. We will provide written report with specific comments on pros and cons along with suggestions for improvements.We have previously provided beta testing for LI-COR, Promega, and Corning.

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2017-08-24 21:48:36 -0700

Net Promoter Score of 10 received for Phagocytosis Assay.

March 5, 2016

Positive review received for Dissertation, Thesis and Proposal Editing:

"PERFECTLY DONE!!!!!!"

August 3, 2015

Positive review received for Cell Viability Assays:

"Dr. Yaronvinsky was very thorough and detailed every step in the way and in the finalization of the experiment. His input and experience helped to address issues that improved the quality and information gathered from the experiment. I was able to gather more information than intended thanks to him. I would recommend him and work with him again."

July 13, 2015

Positive review received for Cell Viability Assays:

"Very efficient and communicates well with you every step of the way. Will not continue until he knows you are satisfied with how the experiment should go. Very professional and advice very helpful. Expert advice offered every step of the say."

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