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TNO, The Netherlands Organization for Applied Scientific Research

The Hague, NL

TNO is a major player in a growing international network comprised of leading scientific institutes, companies with ambitious development profiles, universities and other partners in knowledge. The knowledge TNO develops, integrates, will make applicable and puts into practice will only have value if we can use it to have a real social and economic impact.

Working on better solutions: faster, safer, smarter and more efficient. It is that which fascinates, challenges and inspires us. In all our communication we want to show you what we do and the impact our work has on society.

TNO, The Netherlands Organization for Applied Scientific Research has not listed any services.

In vivo Bioavailability/Bioequivalence Studies
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In vitro Microbiome Drug Metabolism Screening
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I-SCREEN

TNO developed the i-screen platform for in vitro evaluation of drug metabolism through intestinal microbiota. Human gut microbiota are cultured anaerobically in a multi-well system to mimic the human intestinal in vivo metabolism. This allows for determining the potential of intestinal microbiota to metabolize drug candidates.

I-SCREEN

TNO developed the i-screen platform for in vitro evaluation of drug metabolism through intestinal microbiota. Human gut microbiota are cultured anaerobically in a multi-well system to mimic the human intestinal in vivo metabolism. This allows for determining the potential of intestinal microbiota to metabolize drug candidates.

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Accelerated Mass Spectrometry
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Stable Cell Line Generation
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Liver Steatosis Animal Models
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In years of research, TNO has gained a wealth of knowledge about a number of disease areas (a.o. atherosclerosis, diabetes, obesity, fibrosis, and diabetic complications such as NASH and diabetic nephropathy) and disease processes. This expertise is supported by many validated in vitro and in vivo models, a range of - often unique... Show more »

In years of research, TNO has gained a wealth of knowledge about a number of disease areas (a.o. atherosclerosis, diabetes, obesity, fibrosis, and diabetic complications such as NASH and diabetic nephropathy) and disease processes. This expertise is supported by many validated in vitro and in vivo models, a range of - often unique - read-out parameters, and an extensive academic and clinical network. Our experience enables us to offer you an unmatched variety of administration routes and optimal study conditions.

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NASH (Non-Alcoholic Steatohepatitis)
In vivo Toxicity Testing
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TNO has a long-standing reputation in toxicological research and compound safety evaluation. We are very experienced in the field of non-clinical research. Therefore, TNO is the partner of first choice for consultancy on or performance of complete non-clinical packages for your compound. From small molecules to biopharmaceuticals,... Show more »

TNO has a long-standing reputation in toxicological research and compound safety evaluation. We are very experienced in the field of non-clinical research. Therefore, TNO is the partner of first choice for consultancy on or performance of complete non-clinical packages for your compound. From small molecules to biopharmaceuticals, TNO will perform your studies promptly, reliably and in accordance with the latest guidelines.
Please view the following information sheets for more information about are areas of research

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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
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TNO's kinetics and metabolism experts will help you select and further develop your candidate drugs. Working in cooperation with our pharmacologists, our experts develop systems to explore kinetics and metabolism in disease models.

Please view the following information sheets for more information about are areas of research.

TNO's kinetics and metabolism experts will help you select and further develop your candidate drugs. Working in cooperation with our pharmacologists, our experts develop systems to explore kinetics and metabolism in disease models.

Please view the following information sheets for more information about are areas of research.

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Biomarker Analysis
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Molecular Imaging
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Metabolic Disease Animal Models
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Custom Cardiovascular Animal Models
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In vivo Drug Efficacy Testing
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Microbiome Studies
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Determine microbiota composition in human subjects, and allow for accurate measurement and monitoring of microbiomes in various stages of scientific research to accelerate advancement and discovery. TNO has a wide range of available tools to increase understanding of the impact and interaction of the microbiome on human health.... Show more »

Determine microbiota composition in human subjects, and allow for accurate measurement and monitoring of microbiomes in various stages of scientific research to accelerate advancement and discovery. TNO has a wide range of available tools to increase understanding of the impact and interaction of the microbiome on human health. This is key to determining how various diseases change the body, and how various drugs can impact that change.

TNO allows the analysis of microbiota compositions on samples from a broad range of origins and matrices. We use techniques such as amplicon sequencing, whole genome sequencing (WGS), metagenomics, RNAseq and qPCR.

TNO can also support every aspect of management of these large data sets. From data handling and storage, statistical and biological analysis and interpretation to advanced machine-learning tools to identify patterns in the complex data. Furthermore, our platforms allow for high-throughput ex-vivo analysis of shifts in microbiota upon exposure to compounds, ingredients or other changes. This can accelerate understanding of drug interactions and metabolism, and the relation between microbiome and diseases such as IBD and colon cancer, which will lead to further understanding of how shifts in the microbiome impact health.

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Drug Transporter Assays
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Ex vivo Intestinal Tissue Model
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InTESTine, a new in vitro intestinal model using ex vivo intestinal epithelium, uses healthy porcine or human tissue to model and predict drug absorption in human subjects. InTESTine allows the simultaneous study of multiple intestinal segments (duodenum, jejunum, ileum & colon) to determine regional differences in absorption... Show more »

InTESTine, a new in vitro intestinal model using ex vivo intestinal epithelium, uses healthy porcine or human tissue to model and predict drug absorption in human subjects. InTESTine allows the simultaneous study of multiple intestinal segments (duodenum, jejunum, ileum & colon) to determine regional differences in absorption under controlled conditions. This enables screening for toxicity (safety), early immune responses, and/or endocrine responses to potential drug therapies at the pre-clinical stage.

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Liver Fibrosis Animal Models
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In years of research, TNO has gained a wealth of knowledge about a number of disease areas (a.o. atherosclerosis, diabetes, obesity, fibrosis, and diabetic complications such as NASH and diabetic nephropathy) and disease processes. This expertise is supported by many validated in vitro and in vivo models, a range of - often unique... Show more »

In years of research, TNO has gained a wealth of knowledge about a number of disease areas (a.o. atherosclerosis, diabetes, obesity, fibrosis, and diabetic complications such as NASH and diabetic nephropathy) and disease processes. This expertise is supported by many validated in vitro and in vivo models, a range of - often unique - read-out parameters, and an extensive academic and clinical network. Our experience enables us to offer you an unmatched variety of administration routes and optimal study conditions.

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Project and Process Management
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Process Consulting
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Animal Models and Studies
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Animal Models of Disease
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Metabolic Animal Models
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Hepatic Animal Models
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Cardiovascular Animal Models
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Biology
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Cells and Tissues
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Mammalian Cell Culture
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Ex Vivo Models and Assays
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Microbiology
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Microbiology Assays
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Imaging & Spectroscopy
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Radiography
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Nuclear Imaging
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Pharmacology & Toxicology
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Safety Pharmacology
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Bioanalysis
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Biomarkers
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In vitro Bioavailability/Bioequivalence Studies
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Geological Sciences
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Geological Science & Energy
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Geophysics
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Induced Pluripotent Stem Cell (iPSC) Culture
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Cell and Tissue Culture
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Cell and Tissue Culture Services

Cell and Tissue Culture Services

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Embryonic Stem Cell (ESC) Culture
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In vivo PK/PD Studies
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Omics
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Spectroscopy
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Scientific Sourcing
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Obesity Animal Models
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Toxicology
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Toxicology Services

Toxicology Services

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Drug Discovery & Development
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Drug Discovery & Development Services

Drug Discovery & Development Services

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Pharmacology
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Pharmacology Services

Pharmacology Services

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