TGA BioServices, Inc.

TGA Sciences, Inc. offers the client experience in the production of customized antibodies for research and clinical applications. Working as an extension of the client's laboratory, we offer customer consultations and progress reports at each phase of production. TGA Sciences, Inc. is AAALAC accredited, USDA registered, OLAW licensed and maintains an internal Institutional Animal Care and Use Committee (IACUC) in accordance with USDA and HHS regulations and guidelines.

• The development of toxicology studies and quantitation for Pharmacokinetic studies.
• Dose ranging studies.
• Bioequivalence and bioavailability studies.

TGA Sciences, Inc. offers the client experience in the production of customized antibodies for research and clinical applications. Working as an extension of the client's laboratory, we offer customer consultations and progress reports at each phase of production. TGA Sciences, Inc. is AAALAC accredited, USDA registered, OLAW licensed and maintains an internal Institutional Animal Care and Use Committee (IACUC) in accordance with USDA and HHS regulations and guidelines.

Immunogenicity testing for the release and stability studies of bulk and finished clinical product, as well
as raw material screening.

TGA Sciences, Inc. offers the client experience in the production of customized antibodies for research and clinical applications. Working as an extension of the client's laboratory, we offer customer consultations and progress reports at each phase of production. TGA Sciences, Inc. is AAALAC accredited, USDA registered, OLAW licensed and maintains an internal Institutional Animal Care and Use Committee (IACUC) in accordance with USDA and HHS regulations and guidelines.

• The development of toxicology studies and quantitation for Pharmacokinetic studies.
• Dose ranging studies.
• Bioequivalence and bioavailability studies.

ATP Cell Survival Bioassays
UVB Cell Survival Bioassays
H2O2 Cell Survival Bioassays

small scale

TGA Sciences, Inc. offers our clients a complete package of development, optimization and quantification systems utilized in pre-clinical through Phase IV studies, all in compliance with GLP and cGMP requirements when requested by the client. There is an additional charge for GLP and cGMP methods as compared to R&D projects.

We have a strong track record of expertise in the development of complex and infrequently used methods to assist our clients in their research. We offer weekly progress reports and/or teleconferences to ensure the client is up to date on all aspects of their projects.

Capabilities include:

• Measurement of small molecules, peptides and large proteins for R&D or product release (cGMP)
• Immunoassays for the monitoring of antibody or protein levels throughout a clinical study in complete compliance with GLP guidelines
• Development of an Immunoassay-based screening protocol against your lead compound
• Assay design and detection systems for antibodies with unique specifications; Quantitative detection systems for antibodies with unique specifications
• Quantitative detection systems for the determination of contaminants in highly purified products
• Immunoassays utilized for the detection of cytokines or cell surface markers
• Use of commercial kits in compliance with cGMP or GLP guidelines
• Monoclonal antibody screening (Western blot or ELISA)

Immunoassay formats include:

• Bridging Assay
• Competitive Technique
• Direct Binding Assay Study
• HACA
• HAMA
• Immunogenicity Assays
• Immunoglobulin Screening
• Isotyping
• Client Specific Assay Formats

Additional immunoassay capabilities include:

• Immunoassay Validation
• Multiplex Assay
• Immunoassay Consulting

Pharmacology Services

Drug Discovery & Development Services

TGA Sciences, Inc. offers the client experience in the production of customized antibodies for research and clinical applications. Working as an extension of the client's laboratory, we offer customer consultations and progress reports at each phase of production. TGA Sciences, Inc. is AAALAC accredited, USDA registered, OLAW licensed and maintains an internal Institutional Animal Care and Use Committee (IACUC) in accordance with USDA and HHS regulations and guidelines.

• The development of toxicology studies and quantitation for Pharmacokinetic studies.
• Dose ranging studies.
• Bioequivalence and bioavailability studies.