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TCG LifeSciences

1 Order Completed
Kolkata, West Bengal, IN

About TCG LifeSciences

Founded: 2001 Type: Privately Held Size: 501-1000 employees

TCG Lifesciences Limited (formerly “Chembiotek Research International”) is a leading contract research services company in the area of early drug discovery and development. We started our operations in the year 2001 in India, currently we have our presence in United States, Europe, Japan and Australia.

We... Show more »

TCG Lifesciences Limited (formerly “Chembiotek Research International”) is a leading contract research services company in the area of early drug discovery and development. We started our operations in the year 2001 in India, currently we have our presence in United States, Europe, Japan and Australia.

We have a strong talent pool of 800+ qualified and trained scientists, drawn from the best national and international institutes and industry.

Spread over 250,000 sq. ft. of space our services span from specific solutions to integrated discovery projects across multiple therapeutic areas with focus on Central Nervous System (CNS), Inflammation & Pain, Metabolic Disorders and Infectious Diseases. Our research infrastructure includes world class chemistry and biology laboratories, animal facility, electrophysiology laboratory, BSL 2 and 3 laboratory, and cGMP facilities at our R&D centers in Kolkata and Hyderabad, India.

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Our Services (55)


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Electrophysiology

Price on request

Field Potential Recording in Hippocampal Slices:
Understanding learning, memory, stress, depression, anxiety, addition and fear
LTP, LTD, Dose Response
Effects of compounds on central synaptic function
Mechanism of Action of NCEs
Effect of NCEs on Learning and Memory

Conventional Patch Clamp:
Whole cell DRC
Multiple... Show more »

Field Potential Recording in Hippocampal Slices:
Understanding learning, memory, stress, depression, anxiety, addition and fear
LTP, LTD, Dose Response
Effects of compounds on central synaptic function
Mechanism of Action of NCEs
Effect of NCEs on Learning and Memory

Conventional Patch Clamp:
Whole cell DRC
Multiple patch configurations
Single channel recording, single channel kinetics
Recording from specialized and primary cell lines
hERG assay
Also available: patch clamping of hippocampal slices

Automated Patch Clamp:
High throughput assay of ion channels.
Offsite facility is available on arrangement with academic partners.

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Automated patch clamp Manual patch clamp

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In vitro Toxicity Testing

Price on request

Phospholipidosis – CHO-K1/HepG2 cells, NBD-PE uptake, Fluro/colorimetry
Hemolysis – Human/Rat/Mice Blood, hemoglobin in plasma by colorimetry
Cell viability/proliferation assay – MTT, Cell Titre(ATP) Glo, LDH release

Phospholipidosis – CHO-K1/HepG2 cells, NBD-PE uptake, Fluro/colorimetry
Hemolysis – Human/Rat/Mice Blood, hemoglobin in plasma by colorimetry
Cell viability/proliferation assay – MTT, Cell Titre(ATP) Glo, LDH release

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Human Mouse Rat

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In vitro Genotoxicity Testing

Price on request

AMES Test
Plate Incorporation
AMES-MPF (Xenometric)
Micronucleus (IVMN)
In Vitro:
CHO-K1
Human peripheral blood

AMES Test
Plate Incorporation
AMES-MPF (Xenometric)
Micronucleus (IVMN)
In Vitro:
CHO-K1
Human peripheral blood

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In vivo Cardiotoxicity Screening

Price on request

hERG
Radio-Ligand Binding
Fluorescence Polarization
Manual Patch Clamp
NaV1.5

hERG
Radio-Ligand Binding
Fluorescence Polarization
Manual Patch Clamp
NaV1.5

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Safety Pharmacology

Price on request
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In vivo Pharmacology Studies

Price on request

TCG Lifesciences In Vivo service provides validated platforms for in-depth studies in the therapeutic areas of Pain, Inflammation and CNS with special focus on Neuropathic pain. Our talented research team led by Ph.D. scientists in Pharmacology and Veterinary Sciences provide complete support from study designing to final data... Show more »

TCG Lifesciences In Vivo service provides validated platforms for in-depth studies in the therapeutic areas of Pain, Inflammation and CNS with special focus on Neuropathic pain. Our talented research team led by Ph.D. scientists in Pharmacology and Veterinary Sciences provide complete support from study designing to final data analysis and reporting. The TCGLS biology team offers the flexibility of using our platforms or developing customized models efficiently to enable your preclinical discovery program. Our team of In Vivo scientists work in concert with our In Vitro and Bioanalytical teams to support more complex study designs like PK/PD correlation including biomarker analysis and maximize the value of obtained research data.

The animal house of TCG Lifesciences is equipped with a state of art holding facility as well as in house breeding capabilities for reliable supply of rodent strains commonly required to support discovery research. The facility strictly adheres to the ethical guidelines of the Government of India and is under supervision of a fully compliant Institutional Animal Ethics Committee (IAEC). Our facility is licensed by Government of India to import special rodent strains as may be required by study protocols.

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Immunology Pain Inflammation

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Cell Proliferation Assays

Price on request
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Cell Viability Assays

Price on request
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In vitro Hemolysis Assay

Price on request
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Drug Induced Phospholipidosis (PLD) Assay

Price on request
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Chemical Synthesis

Price on request

We routinely do custom synthesis of scaffolds, building blocks, special reagents, ligands for our clients. Typical scale varies from mg to kilos. We have experience in synthesizing diverse classes of compounds including optically active ones.

Special tools include

We routinely do custom synthesis of scaffolds, building blocks, special reagents, ligands for our clients. Typical scale varies from mg to kilos. We have experience in synthesizing diverse classes of compounds including optically active ones.

Special tools include

  • Photo Reaction
  • Resin Based Purification
  • Carbonylation
  • Ozonolysis
  • Chiral Separation in gm scale using SFC.

Timely delivery in predefined quality.

Online access to project information through secured server.

Final product/intermediates well characterized using our state-of-the-science analytical facility (NMR (350 MHz), HPLC, or LC-MS).

Flexible synthetic scale from milligrams to kilogram.

We put our major focus on cheap, environmentally benign and readily available starting materials, reagents and catalysts.

We supply written reports in the preferred format needed by the client for each compounds which includes protocol and data set.

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HPLC NMR LC-MS Photo Reaction Ozonolysis Chiral Separation gram milligram kilogram Show 8 more tags Show less

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Cell Culture Scale-Up

Price on request

We have a well-established kilo laboratory for the synthesis of compounds in multi grams to kilograms level. During kilo synthesis we always look for the cost effectiveness.

  • Process optimization at different batch sizes of major emphasis.
  • International standard walk-in-hoods.
  • Kilo lab with capacity up to 160 L reactors... Show more »

We have a well-established kilo laboratory for the synthesis of compounds in multi grams to kilograms level. During kilo synthesis we always look for the cost effectiveness.

  • Process optimization at different batch sizes of major emphasis.
  • International standard walk-in-hoods.
  • Kilo lab with capacity up to 160 L reactors with distillation facility. Other reactors include one 50L and several 20L all glass reactors. Other facilities include chromatographic columns (up to 12 inch diameter) and high capacity (20L) rotavapors from Buchi, Switzerland.
  • In process-control.
  • Reaction calorimetry using Metler's RC1.
  • cGMP laboratory (class 100,000) with 50 L all glass reactor and facility to carry out small scale synthesis of high potency molecules.
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Biopharmaceutical Process Development

Price on request

Our expertise lies in synthesizing chemical entities of any structural complexity, including new ones.

  • We put our major thrust on R&D for the new synthetic methodology.
  • A facility equipped with low temperature circulators, vacuum evaporators, lyophilizer, and standard Schlenk lines for handling air/moister sensitive... Show more »

Our expertise lies in synthesizing chemical entities of any structural complexity, including new ones.

  • We put our major thrust on R&D for the new synthetic methodology.
  • A facility equipped with low temperature circulators, vacuum evaporators, lyophilizer, and standard Schlenk lines for handling air/moister sensitive samples.
  • Parr hydrogenator, and Autoclave for hydrogenation and special type reactions.
  • Ability to perform all the reactions under one roof.
  • Carbonylation facility.
  • Ozonizer.
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Drug Discovery

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Medicinal Chemistry

Price on request

Our team of experienced medicinal chemists has a proven track record in running integrated discovery programs starting from ’hit generation’ to ‘identifying preclinical candidates’. The team works in close collaboration with In Vitro pharmacologists, DMPK and In Vivo pharmacologists, and computational chemists. The programs have... Show more »

Our team of experienced medicinal chemists has a proven track record in running integrated discovery programs starting from ’hit generation’ to ‘identifying preclinical candidates’. The team works in close collaboration with In Vitro pharmacologists, DMPK and In Vivo pharmacologists, and computational chemists. The programs have three main stages:

  • Hit generation and hit validation
  • Lead generation
  • Lead optimization

Designing of compounds for Novel targets or Fast-followers program are done following different approaches:

  • Ligand based approach, more specific pharmacophore based approach is commonly done.
  • Also in silico screening approach of commercially available library database (over 2 M compounds) are done followed by purchase and In Vitro screening of a subset for hit finding.

In case of fast-followers programs our medicinal chemists have been instrumental by proposing novel new molecular entities (NME) and also tool compounds to take the program forward in stringent time frame.

For synthesis, in house parallel synthesis expertise are used majorly to build focused libraries to answer key Structure Activity Relationship (SAR) and Structure Property Relationship (SPR) questions.

Syntheses in singleton mode are also run in parallel.

We have successfully completed projects from ‘early hit to preclinical development stage’ by developing a number of lead candidates with required biological properties for our clients within the specified time frame and maintaining highest standards of data quality.

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Teledyne ISCO CombiFlash Biotage Quad 3 HPLC

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Biochemistry & Molecular Biology

Price on request

Develop innovative assays and screening methods to evaluate the effects of chemical compounds on cellular, molecular and biochemical processes. The screens, further help to unravel cell functions/biological process and could become potential therapeutic candidates in drug development pipeline.

Expertise includes:

Develop innovative assays and screening methods to evaluate the effects of chemical compounds on cellular, molecular and biochemical processes. The screens, further help to unravel cell functions/biological process and could become potential therapeutic candidates in drug development pipeline.

Expertise includes:

  • Cell line development services in line with assay requirements (validation and optimization included)
  • Diverse range of In Vitro assays (primary, secondary and tertiary) optimized and validated in multiple therapeutic areas.
  • Adopting screening assays from bench scale assays to automation and scale up in 96 and 384 plate formats.
  • Tech transfer technology effectively implemented
  • Statistical analysis of the data sacrosanctly satisfy pre-defined acceptance criteria
  • Primary cell-based specialized assays across therapeutic areas.
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In vitro ADME/DMPK Studies

Price on request
  • Physicochemical screening – Kinetic & thermodynamic solubility, chemical stability, LogD, LogP
  • Biorelevant solubility – FaSSIF, FeSSIF, SGF
  • Cell permeability – PAMPA, Caco-2, MDCK-II, MDCK-MDR1
  • Transporter assay – PGP, BCRP, MRP-2
  • Metabolic stability – S9, microsomes & hepatocytes
  • Microsomal & hepatocellular... Show more »
  • Physicochemical screening – Kinetic & thermodynamic solubility, chemical stability, LogD, LogP
  • Biorelevant solubility – FaSSIF, FeSSIF, SGF
  • Cell permeability – PAMPA, Caco-2, MDCK-II, MDCK-MDR1
  • Transporter assay – PGP, BCRP, MRP-2
  • Metabolic stability – S9, microsomes & hepatocytes
  • Microsomal & hepatocellular binding
  • Drug-drug interaction – CYP inhibition & induction
  • Time dependent drug-drug interaction (TDI)
  • Plasma protein binding
  • Plasma stability
  • Brain tissue binding
  • Blood to plasma ratio
  • Metabolite identification – Microsomes & hepatocytes
  • CYP450 reaction phenotyping
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In Vitro ADME Drug Discovery

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In vivo PK/PD Studies

Price on request
  • Discovery formulation development
  • Bioavailability study (PO, IP, IV, IM, SC, ID, IT etc.)
  • Preclinical bioequivalence study
  • Single/multiple dose PK with bioanalysis
  • Cassette (5-in-one) PK with bioanalysis
  • Dry blood spot (DBS) sampling & analysis
  • Tissue/ CSF distribution study
  • CNS penetration study
  • Drug... Show more »
  • Discovery formulation development
  • Bioavailability study (PO, IP, IV, IM, SC, ID, IT etc.)
  • Preclinical bioequivalence study
  • Single/multiple dose PK with bioanalysis
  • Cassette (5-in-one) PK with bioanalysis
  • Dry blood spot (DBS) sampling & analysis
  • Tissue/ CSF distribution study
  • CNS penetration study
  • Drug administration through IV infusion/osmotic pump
  • Non-compartmental pharmacokinetic analysis, WinNonLin
  • Metabolite identification/quantitation

Toxicokinetic (TK) Modeling:

  • Formulation optimization with exposure evaluation
  • LC-MS/MS bioanalysis of TK samples
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Mouse Rat

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Bioanalysis

Price on request
  • Non-GLP LC-MS/MS bioanalytical support
  • Bioanalysis of biofluids – Plasma, blood, CSF, urine, bile, synovialfluid etc.
  • Bioanalysis of tissues – Brain, liver, spleen, lung, muscle, paw, fat tissue etc.
  • Biomarker analysis
  • Peptide analysis
  • Chiral analysis
  • Non-GLP LC-MS/MS bioanalytical support
  • Bioanalysis of biofluids – Plasma, blood, CSF, urine, bile, synovialfluid etc.
  • Bioanalysis of tissues – Brain, liver, spleen, lung, muscle, paw, fat tissue etc.
  • Biomarker analysis
  • Peptide analysis
  • Chiral analysis
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Neuropathic Pain Animal Models

Price on request
  • Spinal Nerve Ligation (Chung’s model)
  • Spared Nerve Injury (Woolf’s model)
  • Chronic Constriction Injury (Bennett’s model)
  • Partial Sciatic Nerve Ligation (Selzter’s model)
  • Tibial Nerve Transection
  • Diabetic neuropathy
  • Spinal Nerve Ligation (Chung’s model)
  • Spared Nerve Injury (Woolf’s model)
  • Chronic Constriction Injury (Bennett’s model)
  • Partial Sciatic Nerve Ligation (Selzter’s model)
  • Tibial Nerve Transection
  • Diabetic neuropathy
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CNS/Neurology

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Acute Inflammatory Pain Animal Models

Price on request
  • Ultraviolet radiation induced Hyperalgesia
  • Freund's Adjuvant induced Hyperalgesia
  • Formalin induced Pain
  • Carrageenan induced Hyperalgesia
  • MIA/MMT-induced OA
  • Post Operative Pain (POP, Brennan’s Model)
  • Ultraviolet radiation induced Hyperalgesia
  • Freund's Adjuvant induced Hyperalgesia
  • Formalin induced Pain
  • Carrageenan induced Hyperalgesia
  • MIA/MMT-induced OA
  • Post Operative Pain (POP, Brennan’s Model)
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Nociceptive Pain Animal Models

Price on request
  • Rat Pinch Model
  • Tail Flick
  • Rat Pinch Model
  • Tail Flick
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Visceral Pain Animal Models

Price on request

Acetic Acid induced Writhing

Acetic Acid induced Writhing

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Acute Inflammation Animal Models

Price on request
  • Carrageenan induced Paw Edema
  • Carrageenan-Air Pouch Inflammation
  • LPS induced Endotoxemia
  • LPS induced Lung Inflammation
  • Delayed Type Hypersensitivity
  • Carrageenan induced Paw Edema
  • Carrageenan-Air Pouch Inflammation
  • LPS induced Endotoxemia
  • LPS induced Lung Inflammation
  • Delayed Type Hypersensitivity
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Chronic Inflammation Animal Models

Price on request
  • Collagen induced Arthritis
  • DSS induced Colitis
  • BDL induced Liver Fibrosis
  • BDL induced Liver Cirrhosis
  • Collagen induced Arthritis
  • DSS induced Colitis
  • BDL induced Liver Fibrosis
  • BDL induced Liver Cirrhosis
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In vitro Cardiotoxicity Screening

Price on request
  • hERG
    • Radio-Ligand Binding
    • Fluorescence Polarization
    • Manual Patch Clamp
  • NaV1.5
  • hERG
    • Radio-Ligand Binding
    • Fluorescence Polarization
    • Manual Patch Clamp
  • NaV1.5
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Toxicology

Price on request
  • Phospholipidosis – CHO-K1/HepG2 cells, NBD-PE uptake, Fluro/colorimetry
  • Hemolysis – Human/Rat/Mice Blood, hemoglobin in plasma by colorimetry
  • Cell viability/proliferation assay – MTT, Cell Titre(ATP) Glo, LDH release
  • Phospholipidosis – CHO-K1/HepG2 cells, NBD-PE uptake, Fluro/colorimetry
  • Hemolysis – Human/Rat/Mice Blood, hemoglobin in plasma by colorimetry
  • Cell viability/proliferation assay – MTT, Cell Titre(ATP) Glo, LDH release
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CNS/Neurology Animal Models

Price on request
  • Contextual Fear Conditioning (CFC) test for Learning and Memory
  • Novel Object Recognition Test (NORT) for Learning and Memory
  • Novel Environment Recognition Test (NERT) for Learning and Memory
  • Forced Swim Test for Depression
  • Stress induced Hyperthermia for Anxiety
  • MPTP induced Parkinsonism for Neuro-degeneration
    -... Show more »
  • Contextual Fear Conditioning (CFC) test for Learning and Memory
  • Novel Object Recognition Test (NORT) for Learning and Memory
  • Novel Environment Recognition Test (NERT) for Learning and Memory
  • Forced Swim Test for Depression
  • Stress induced Hyperthermia for Anxiety
  • MPTP induced Parkinsonism for Neuro-degeneration
  • Synaptic Plasticity changes (Field Potential recording in Hippocampal slices)
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Drug Discovery

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Pain/Neuropathy Animal Models

Price on request

Pain/Neuropathy Animal Models Services

Pain/Neuropathy Animal Models Services

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Inflammation Animal Models

Price on request

Inflammation Animal Models Services

Inflammation Animal Models Services

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Computational Drug Discovery

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Immunology Animal Models

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Immunology Animal Models Services

Immunology Animal Models Services

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Electrophysiology Animal Models

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Biology

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Biology Services

Biology Services

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Animal Models and Studies

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Pharmacology

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Pharmacology Services

Pharmacology Services

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Animal Models of Disease

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Drug Discovery & Development

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Pharmacology & Toxicology

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Pharmacology & Toxicology Services

Pharmacology & Toxicology Services

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Mammalian Cell Culture

Price on request

Mammalian Cell Culture Services

Mammalian Cell Culture Services

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Cell and Tissue Culture

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Cell and Tissue Culture Services

Cell and Tissue Culture Services

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Cells and Tissues

Price on request

Cells and Tissues Services

Cells and Tissues Services

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Manufacturing Services

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Manufacturing Services

Manufacturing Services

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Synthetic Chemistry

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Synthetic Chemistry Services

Synthetic Chemistry Services

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Chemistry and Materials

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Chemistry and Materials Services

Chemistry and Materials Services

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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ADME/DMPK Studies Services

ADME/DMPK Studies Services

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In vivo Toxicity Testing

Price on request

In vivo Toxicity Testing Services

In vivo Toxicity Testing Services

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Cell Viability & Proliferation Assays

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Cell Viability & Proliferation Assays Services

Cell Viability & Proliferation Assays Services

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Cell-Based Assays

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Cell-Based Assays Services

Cell-Based Assays Services

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Cytotoxicity Assays

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Cytotoxicity Assays Services

Cytotoxicity Assays Services

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Biospecimen Management and Storage

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Biospecimens

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Human Biobanking

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Compound IC50 Assays

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Toxicity Animal Models

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