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SynVivo Inc.

Huntsville, Alabama, US

SynVivo® is a physiological, cell-based microfluidic platform that provides a biologically realistic microenvironment allowing real-time study of cellular behavior, drug delivery and drug discovery. SynVivo 3D tissue models recreate complex in vivo microenvironments including scale, morphology, hemodynamics, and cellular interactions with a side-by-side architecture enabling real-time visualization and analysis. SynVivo's 3D tissue models have been extensively validated in oncology, neuroscience, inflammation and toxicology applications. Models include SynTumor (Cancer), SynBBB (blood brain barrier), SynRAM (Inflammation) and SynTox (Toxicology). Services include target validation, compound screening, biomarker analysis, ADME/Tox and mechanism of action studies. Assay Development services can be performed to develop new tissue/organ models, assays or custom chip designs. See http://www.synvivobio.com

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SynVivo® is a physiological, cell-based microfluidic platform that provides a biologically realistic microenvironment allowing real-time study of cellular behavior, drug delivery and drug discovery. SynVivo 3D tissue models recreate complex in vivo microenvironments including scale, morphology, hemodynamics, and cellular interactions with a side-by-side architecture enabling real-time visualization and analysis. SynVivo's 3D tissue models have been extensively validated in oncology, neuroscience, inflammation and toxicology applications. Models include SynTumor (Cancer), SynBBB (blood brain barrier), SynRAM (Inflammation) and SynTox (Toxicology). Services include target validation, compound screening, biomarker analysis, ADME/Tox and mechanism of action studies. Assay Development services can be performed to develop new tissue/organ models, assays or custom chip designs. See http://www.synvivobio.com

Unlike well plate testing performed under static conditions, SynVivo reproduces the realistic dynamic conditions for analyzing cell-drug and cell-cell interactions thereby providing an accurate in vitro platform to study and elucidate the mechanisms of success and failure. Compared to in vivo animal studies, SynVivo allows real-time visualization and analysis of the assay in a controlled environment.

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Cell Permeability Assay
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3D Tumor Model
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Cell Migration Assays
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In vitro Inflammation Models
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SynRAM 3D tissue model www.synvivobio.com/Synram allows the study of the entire inflammation pathway in a realistic and dynamic environment. SynRAM delivers a physiologically realistic model and enables real-time tracking of rolling, adhesion and migration processes by mimicking a histological slice of co-cultured tissue and/or... Show more »

SynRAM 3D tissue model www.synvivobio.com/Synram allows the study of the entire inflammation pathway in a realistic and dynamic environment. SynRAM delivers a physiologically realistic model and enables real-time tracking of rolling, adhesion and migration processes by mimicking a histological slice of co-cultured tissue and/or tumor cells with a lumen of endothelial cells. SynRAM has been successfully validated against in vivo studies showing excellent correlation with rolling velocities, adhesion patterns and migratory processes.

This model can be used for studies of:
Real-time, quantitative immune-endothelial interactions
Cell rolling, adhesion and migration
Screening for cell surface biomarkers
Target identification
Screening for activators/inhibitors of inflammation
www.synvivobio.com/videos
www.synvivobio.com/publications

Selected Publications:
(1) A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil-endothelium interaction. Soroush F, Zhang T, King DJ, Tang Y, Deosarkar S, Prabhakarpandian B, Kilpatrick LE, Kiani MF. J Leukoc Biol November 2016 100:1027–1035.
(2) Bioinspired Microfluidic Assay for In Vitro Modeling of Leukocyte–Endothelium Interactions. G. Lamberti, B. Prabhakarpandian, C. Garson, A. Smith, K. Pant, B. Wang, and M.F. Kiani. Anal. Chem., 2014, 86 (16), pp 8344–8351.doi:10.1021/ac5018716

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Brown Rat (Rattus norvegicus)
Human
Mouse
Immunology
Inflammation
Cell Invasion & Migration Assays
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Blood Brain Barrier Screening Platform
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SynBBB 3D blood brain barrier model from SynVivo recreates the in vivo microenvironment by mimicking a histological slice of brain tissue cells in communication with endothelial cells across the blood brain barrier (BBB). See http://www.synvivobio.com/synbbb. Shear-induced endothelial cell tight junctions, which cannot be achieved... Show more »

SynBBB 3D blood brain barrier model from SynVivo recreates the in vivo microenvironment by mimicking a histological slice of brain tissue cells in communication with endothelial cells across the blood brain barrier (BBB). See http://www.synvivobio.com/synbbb. Shear-induced endothelial cell tight junctions, which cannot be achieved in the Transwell® model, are easily achieved in the SynBBB model using physiological fluid flow. Formation of tight changes can be measured using biochemical or electrical analysis (assessing changes in electrical resistance) with the SynVivo Cell Impedance Analyzer. Interactions between brain tissue cells and endothelial cells are readily visualized in the SynBBB assay. Transwell models do not allow real-time visualization of these cellular interactions, which are critical for understanding of the BBB microenvironment.

The SynBBB model can be used for the following studies:

•Drug permeability: Evaluate real-time permeability of therapeutics and small molecules across the endothelium of the BBB. Readouts can be biochemical or electrical analysis (assessing changes in electrical resistance)

•Inflammation: Understand the underlying mechanisms of inflammatory responses on the regulation of the BBB.

•Cell migration: Visualize and quantify in real-time migration of immune cells across the BBB.

•Tight junction proteins: Determine the levels of tight junction proteins namely zonula occludens, claudins and occludins which regulate the BBB.

•Transporter proteins: Analyze functionality of transporter proteins (e.g. Pgp) in normal and dysfunctional BBB.

•Omic changes: Perform genomic, proteomic and metabolic analysis on normal and dysfunctional BBB.

•Neurotoxicity: Analyze toxicity effects of chemical, biological and physical agents on the cells of the BBB.

•Neuro-oncology: Investigate effects of the tumor cells on the BBB.

Human and Rat BBB model can be used for the studies indicated using primary cells or cell lines.

Recent Publications using the SynBBB model
(1) Trastuzumab Distribution in an In-Vivo and In-Vitro Model of Brain Metastases of Breast Cancer Tori B. Terrell-Hall, Mohamed Ismail Nounou, Fatema El-Amrawy, Jessica I.G. Griffith and Paul R. Lockman Oncotarget. 2017; 8:83734-83744
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=19634&path[]=62725
(2) Permeability across a novel microfluidic blood tumor barrier model. Tori B. Terrell Hall, Amanda G. Ammer, Jessica I. G. Griffith and Paul R. Lockman Fluids and Barriers of the CNS (2017) 14:3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260004/
(3) A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip. S. Deosarkar, B. Prabhakarpandian, B. Wang, J.B. Sheffield, B. Krynska, M. Kiani. PLOS ONE, 2015
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142725
(4) SyM-BBB: A Microfluidic Blood Brain Barrier Model B. Prabhakarpandian, M.-C. Shen, J.B. Nichols, I.R. Mills, M.S.-Wegrzynowicz, M. Aschner, K. Pant, Lab on a Chip, 2013, 13, 1093-1101
http://pubs.rsc.org/en/Content/ArticleLanding/2013/LC/c2lc41208j/#!divAbstract

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Human
Mouse
Rat
CNS/Neurology
Neurodegenerative diseases
Neuroinflammation
Endothelial uptake and BBB transport assays
BBB integrity assessment
Endothelial Permeability (Pe) measurements
Intracellular trafficking analysis
BBB-related gene and protein expression analysis
Blood-brain barrier screening platform
Primary Cells
Cell Adhesion Assays
Price on request

Cell Adhesion, Migration, Rolling Assay

Cell Adhesion, Migration, Rolling Assay

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In vitro ADME/DMPK Studies
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Using our co-culture technologies we are able to screen your most promising drug candidates for toxicity affects before you have to resort to costly and time consuming in vivo trials.

Using our co-culture technologies we are able to screen your most promising drug candidates for toxicity affects before you have to resort to costly and time consuming in vivo trials.

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Drug Discovery
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Many of the most promising drugs discovered today rely not just on bio-chemical interactions but specific cell-cell interactions that can only be simulated with realistic morphology and physiology.

Many of the most promising drugs discovered today rely not just on bio-chemical interactions but specific cell-cell interactions that can only be simulated with realistic morphology and physiology.

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3D Cell-Based Assays
Price on request

You’ve found a drug that works well in static well plate tests. We can assess that drug’s performance under more physiological realistic conditions using the SynVivo technology.
SynVivo® is a physiological, cell-based microfluidic platform that provides a biologically realistic microenvironment allowing real-time study of... Show more »

You’ve found a drug that works well in static well plate tests. We can assess that drug’s performance under more physiological realistic conditions using the SynVivo technology.
SynVivo® is a physiological, cell-based microfluidic platform that provides a biologically realistic microenvironment allowing real-time study of cellular behavior, drug delivery and drug discovery. SynVivo 3D tissue models recreate complex in vivo microenvironments including scale, morphology, hemodynamics, and cellular interactions with a side-by-side architecture enabling real-time visualization and analysis. SynVivo's 3D tissue models have been extensively validated in oncology, neuroscience, inflammation and toxicology applications. Services include target validation, compound screening, biomarker analysis, ADME/Tox and mechanism of action studies. Assay Development services can be performed to develop new tissue/organ models, assays or custom chip designs. See http://www.synvivobio.com

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Pharmacology & Toxicology
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Cell-Based Assays
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Cell Viability & Proliferation Assays
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In vitro Disease Models
Price on request

In vitro Disease Models Services

In vitro Disease Models Services

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Brown Rat (Rattus norvegicus)
Human
Mouse
Oncology
Drug Discovery
Colorectal cancer
Breast cancer
Lung Cancer
Cystic fibrosis
Ovarian Cancer
Toxicology
Specialized Cell-Based Assays
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Specialized Cell-Based Assays Services

Specialized Cell-Based Assays Services

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Cell Death Assays
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Cell Death Assays Services

Cell Death Assays Services

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Drug Absorption Studies
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In vitro Neurodegeneration Models
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Cell Proliferation Assays
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Cell Viability Assays
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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
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ADME and DMPK Studies Services

ADME and DMPK Studies Services

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In vivo PK/PD Studies
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Chemotaxis Assays
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Angiogenesis & Endothelial Cell Assays
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2018-10-10 14:24:51 -1000

Net Promoter Score of 9 received for Drug Delivery Systems.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 8.

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