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Synthelis

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La Tronche, FR

About Synthelis

Type: Privately Held Size: 1-10 employees

Synthelis is a French biotech company specialized in production, purification and characterization of membrane proteins and other difficult-to-express proteins such as ion channels, membrane transporters, GPCRs, membrane enzymes and antigens.
Based on our patented cell-free technology, we offer products and... Show more »

Synthelis is a French biotech company specialized in production, purification and characterization of membrane proteins and other difficult-to-express proteins such as ion channels, membrane transporters, GPCRs, membrane enzymes and antigens.
Based on our patented cell-free technology, we offer products and services to deliver functional proteins as proteoliposomes or in a soluble detergent format. As a result we can support pharmaceutical companies, biotech companies and academic teams in applications such as vaccine development, screening and display technologies, protein delivery, in vitro diagnostics and structural biology.

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Our Services (22)


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Cell-Free Protein Expression

Price on request

We can deliver functional membrane proteins in large quantities and in the format you need, in less time than you would think possible.
The process is simple:

You send us the gene sequence or any genetic material you have.
We carry out a feasibility study to optimize the expression conditions and determine the most... Show more »

We can deliver functional membrane proteins in large quantities and in the format you need, in less time than you would think possible.
The process is simple:

You send us the gene sequence or any genetic material you have.
We carry out a feasibility study to optimize the expression conditions and determine the most appropriate protein functionality test.
The functionality of the protein produced is verified . This quality control procedure can also be offered as a separate analytical service.
On your say-so, we start the production service for your protein.
Compared with other expression systems, Synthelis’ cell-free approach has many competitive advantages, such as:

Preserved functionality with full length proteins
Quantity: 10 to 100 mg
Rapidity: feasibility studies in 2-3 months and production of previously expressed proteins requires 1-2 weeks per mg of protein*.
High success rate: 80-90% of proteins successfully expressed, depending on the protein
Functionality: 80% of tested proteins are functional

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Protein Production

Price on request

Synthelis’ protein production service can provide you with mgs of proteins.
This service is only available when the expression conditions for the protein of interest are established, thus after the feasibility phase, and only if you require it. You will be consulted to identify the:

required output
necessary purity... Show more »

Synthelis’ protein production service can provide you with mgs of proteins.
This service is only available when the expression conditions for the protein of interest are established, thus after the feasibility phase, and only if you require it. You will be consulted to identify the:

required output
necessary purity rates
appropriate quality controls and functionality tests.
The appropriate conditions for expression and purification are then determined, and production can start.

Very short production times can be reached for proteins which have previously been expressed with a high yield. For example, we only need 1-2 weeks per mg of protein such as CXCR4 or Bak. These times may differ depending on the results of the feasibility study or the expression rate for the protein, but an estimation will be included in the report from your feasibility study.

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Proteoliposome Production

Price on request

In Synthelis’ expression system, newly synthesized membrane proteins are embedded directly into liposomes during production, thanks to the addition of 100-nm liposomes (average size) to the reaction mix. This procedure results in the production of proteoliposomes with an average size of 600 nm (400 to 800 nm). Over 80% of the... Show more »

In Synthelis’ expression system, newly synthesized membrane proteins are embedded directly into liposomes during production, thanks to the addition of 100-nm liposomes (average size) to the reaction mix. This procedure results in the production of proteoliposomes with an average size of 600 nm (400 to 800 nm). Over 80% of the proteins we have produced to date were demonstrated to have relevant activity thanks to this procedure, which favors conserved protein conformation, and thus activity. The size and composition of liposomes can be adjusted to ensure the best environment for your protein and to fit to your requirements. Proteoliposomes can also be lyophilized and frozen, without loss of activity.

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Surface Plasmon Resonance (SPR)

Price on request

Synthelis has established a number of quality control protocols consisting of standard and highly sophisticated interchangeable tests. Your specific needs will determine which ones will be implemented.

Synthelis has established a number of quality control protocols consisting of standard and highly sophisticated interchangeable tests. Your specific needs will determine which ones will be implemented.

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Protein Structure Determination

Price on request

Synthelis’ cell-free technology can help you complete your structural biology project by providing functional proteins in large quantities:
-Maintaining the functionality of your target is the key quality control in our process. The advantages of the cell-free protein expression system mean functionality can be unlocked and... Show more »

Synthelis’ cell-free technology can help you complete your structural biology project by providing functional proteins in large quantities:
-Maintaining the functionality of your target is the key quality control in our process. The advantages of the cell-free protein expression system mean functionality can be unlocked and assessed.
- Easily label your proteins according to your needs with non natural or chemically modified amino acids for use in NMR or neutron experiments.
- Take advantage of our detergent-incorporating purification processes, and get highly purified proteins to give the best chance to your crystallization process. To help you even more, we can screen for the best detergent.

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High Throughput Screening (HTS)

Price on request

Synthelis has developed an innovative and flexible production process to provide you with the most suitable and functional proteins, or proteoliposomes, for your assays:
-Functionality can be unlocked by taking advantage of the modulability of the cell-free protein expression machinery. Membrane proteins are only functional in... Show more »

Synthelis has developed an innovative and flexible production process to provide you with the most suitable and functional proteins, or proteoliposomes, for your assays:
-Functionality can be unlocked by taking advantage of the modulability of the cell-free protein expression machinery. Membrane proteins are only functional in their natural environment, they must therefore be embedded into a lipid bilayer mimicking the cell membrane. By inserting proteins into liposomes during production, they conserve appropriate folding and exhibit the most relevant parts of their structure.
- Whether you label your protein or use an immobilized proteoliposome, our cell-free technology can be used for all customizations to speed up and enhance your screening or display technology tool. For example, liposomes can be modified to improve their interaction with surfaces and biochips.
-Consider immobilizing your Orphan Receptors to identify unknown ligands by MS.

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Proteoliposome-Based Full-Length Antigens

Price on request

Synthelis has developed a unique solution to enable immunization with full-length functional proteins, combined with an efficient negative control:
- Full-length antigens cover the full epitope repertoire of your target protein. Additional specific compounds can be used to promote specific folding pathways and improve protein... Show more »

Synthelis has developed a unique solution to enable immunization with full-length functional proteins, combined with an efficient negative control:
- Full-length antigens cover the full epitope repertoire of your target protein. Additional specific compounds can be used to promote specific folding pathways and improve protein stability.
- Your antigen formulated as proteoliposomes have better immunogenic properties, and a longer life-span.
- Eliminate false positives with our relevant negative control, helping you to eliminate all HCP (Host Cell Protein) cross-reactions.

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Vaccine Development

Price on request

Synthelis’ proprietary technology can give you access to difficult-to-express antigens. Using its patented cell-free technology, Synthelis can produce a wide range of membrane proteins and provide full-length proteins, including toxic proteins, giving you access to an extended selection of strategic antigens.A direct consequence... Show more »

Synthelis’ proprietary technology can give you access to difficult-to-express antigens. Using its patented cell-free technology, Synthelis can produce a wide range of membrane proteins and provide full-length proteins, including toxic proteins, giving you access to an extended selection of strategic antigens.A direct consequence of the proteoliposomal formulation provided by Synthelis is an extended life-span for the antigen produced. This can be further extended by producing the pegylated form of the proteoliposome. The liposome composition or size can be readily adapted according to your needs.

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Quality Assurance

Price on request

Synthelis has established a number of quality control protocols consisting of standard and highly sophisticated interchangeable tests. Your specific needs will determine which ones will be implemented.
Synthelis’ ability to produce high quality, high-yield proteins is further enhanced by its expertise in the following... Show more »

Synthelis has established a number of quality control protocols consisting of standard and highly sophisticated interchangeable tests. Your specific needs will determine which ones will be implemented.
Synthelis’ ability to produce high quality, high-yield proteins is further enhanced by its expertise in the following protocols:

Western blot
Coomassie staining
Enzymatic assay
N-terminal sequencing
Cross-linking
SPR (interactions)
ELISA (interactions)
Circular dichroism and FTIR (secondary structure or conformation)
Patch clamp (ion conductance)
Detailed multi-parameter particle analysis: qNANO analysis
Fluorescence resonance energy transfer (interactions)
Other quality tests can be set up to meet your needs.
Additionally, a further bespoke level of quality control can be implemented, thanks to Synthelis’ academic network which includes, ILL (Laue-Langevin Institute ), ESRF (European Synchrotron Radiation Facility), IPBS (Institute of Pharmacology and Structural Biology), CEA (Commissariat à l’énergie atomique et aux énergies alternatives), UJF (Joseph Fourier University)

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Structural Biology

Price on request
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Drug Discovery & Development

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Drug Discovery

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Bioparticle Technology

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Antibody Services

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Biochemistry & Molecular Biology

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Protein Services

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Biomolecular Interaction Analysis

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Product Quality Control

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Hit Identification

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Product Development, Testing, and Packaging

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Formulation Services

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Biology

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Synthelis Protein catalog 2016.pdf

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