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Synthego

367 Orders Completed
Pleasanton, California, US

About Synthego

Synthego’s Full Stack Genome Engineering portfolio includes design and analysis software, synthetic RNA kits, and gene editing services for CRISPR-based research. Our vision is to bring precision and automation to genome engineering, enabling rapid and cost-effective research with consistent results for every scientist.

The company leverages machine learning, automation, and gene editing to build platforms for science at scale. With its foundations in engineering disciplines, the company’s platform technologies vertically integrate proprietary hardware, software, bioinformatics, chemistries, and molecular biology to advance basic research, target validation, and clinical trials.

Our Services (13)


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RNA Synthesis

Price on request

CRISPRevolution Custom RNA is tailored to how you want to do your research: Cpf1, C2c2, S. aureus Cas9, CRISPRi or any novel nuclease. Or to alter the secondary structure of your tracrRNA.

CRISPRevolution Custom RNA

Tell us the sequence you want and we’ll make you the highest quality RNA – Synthego’s CRISPRevolution Custom RNA is a fully custom target sequence guide RNA product for CRISPR genome editing.

Custom RNA 50

Custom RNA 50 is perfect for designing short guide RNAs for nucleases that don’t require long sequences, such as Cpf1. You can use it to design your own Cas9 crRNA and custom 3′ linker to a tracrRNA.

Custom RNA 75

Custom RNA 75 is perfect for designing guide RNAs for nucleases that don’t require guides as long as S. pyogenes Cas9. You can use it to design your own Cas9 tracrRNA and custom 5′ linker to a crRNA.

Custom RNA 100

Custom RNA 100 is perfect for designing full length sgRNA (100-mer) for CRISPR at a practical scale and price point. You can custom design your entire sgRNA sequence from 76-100 nucleotides.

Need Chemical Modifications?

For a chemically modified version of our Custom RNA, we offer 2’-O-methyl and 3’ phosphorothioate internucleotide linkages at the first three 5’ and 3’ terminal RNA residues. Chemically modified sequences can provide additional additional RNA stability with improvements in editing efficiency for particular cell types (e.g. human stem cells) and genomic targets that prove otherwise challenging to edit.

CRISPRevolution Custom RNA Specifications

  • Product Type: Fully Synthetic RNA for CRISPR or other applications
  • Purification: High-Quality Liquid Chromatography SPE
  • Analysis Method: Electrospray Ionization Mass Spectrometry
  • Shipping Format: Nuclease-free Tubes


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RNA Services

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Biology

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Nucleic Acid Services

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Biochemistry & Molecular Biology

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sgRNA Synthesis

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CRISPR sgRNA Libraries

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Induced Pluripotent Stem Cell (iPSC) Genome Editing

Price on request
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CRISPR/Cas9 Knockout Cell Lines

Price on request
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CRISPR Modified Cell Lines

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CRISPR/Cas9 Genome Editing

Price on request
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Knockout Cell Lines

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Knock-In Cell Lines

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  • Positive review for Knockout Cell Lines:

    June 2021

    "Super smooth and nice experience."

  • Positive review for Biology:

    January 2021

    "They were timely and kept us informed at every step of the process. The product received was as expected with no issues."

  • Positive review for RNA Synthesis:

    February 2019

    "My order for gRNAs was completed a week before the scheduled ship date! Very fast turn-around time. I would recommend Synthego to others."

  • Positive review for RNA Synthesis:

    January 2018

    "The service is great and gRNA quality is good."

Synthego has not received any endorsements.