Founded by former SpaceX engineers, Synthego is a leading provider of genome engineering solutions. The company’s flagship product, CRISPRevolution, is a portfolio of synthetic RNA designed for CRISPR genome editing and research.
Synthego’s vision is to bring precision and automation to genome engineering, enabling rapid and cost-effective research with consistent results for every scientist.
We envision the biological laboratory as a construct of discrete, composable modules, much like a computer. We’re building the infrastructure – software, hardware and scientific protocol – to make this a reality.
Our goal is simple: we want to significantly lower the barrier to entry for life sciences research by assembling the groundwork for a decentralized, software-driven, massively parallel world of research.
Our dream is big. We not only want to bring biology into the digital age, we intend to create a revolution in science. Imagine a single scientist running their own fully-automated laboratory at low cost, performing millions of controlled, repeatable experiments per day without human error. We’re building that future.
CRISPRevolution Custom RNA is tailored to how you want to do your research: Cpf1, C2c2, S. aureus Cas9, CRISPRi or any novel nuclease. Or to alter the secondary structure of your tracrRNA.
CRISPRevolution Custom RNA
Tell us the sequence you want and we’ll make you the highest quality RNA – Synthego’s CRISPRevolution Custom RNA is a fully custom target sequence guide RNA product for CRISPR genome editing.
Custom RNA 50
Custom RNA 50 is perfect for designing short guide RNAs for nucleases that don’t require long sequences, such as Cpf1. You can use it to design your own Cas9 crRNA and custom 3′ linker to a tracrRNA.
Custom RNA 75
Custom RNA 75 is perfect for designing guide RNAs for nucleases that don’t require guides as long as S. pyogenes Cas9. You can use it to design your own Cas9 tracrRNA and custom 5′ linker to a crRNA.
Custom RNA 100
Custom RNA 100 is perfect for designing full length sgRNA (100-mer) for CRISPR at a practical scale and price point. You can custom design your entire sgRNA sequence from 76-100 nucleotides.
Need Chemical Modifications?
For a chemically modified version of our Custom RNA, we offer 2’-O-methyl and 3’ phosphorothioate internucleotide linkages at the first three 5’ and 3’ terminal RNA residues. Chemically modified sequences can provide additional additional RNA stability with improvements in editing efficiency for particular cell types (e.g. human stem cells) and genomic targets that prove otherwise challenging to edit.
CRISPRevolution Custom RNA Specifications
Synthego has not received any endorsements.