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Synovel Laboratory LLC

Danbury, CT, US

Synovel Laboratory LLC is an integrated Contract Research Organization (CRO) of medicinal/process chemistry support for pharmaceutical R&D.

At Synovel Laboratory, we are experienced in drug discovery and development projects either in an early LI (Lead Identification) stage, late LO (Lead Optimization) stage or Pre-IND development stage.

We aim to provide the best drug candidate(s) for your project with the optimized potency; physical chemical properties (eg. aqueous solubility, solid crystallinity); DMPK properties (eg. human microsomal stability, animal in vivo PK) and toxicological liability (eg. CYPs inhibition and induction, hERG inhibition, cytotoxicity).

  • Stemming from our talented synthetic/process chemistry team, we provide a variety of products such as API starting material and intermediates, comprehensive collection of clinical reference compounds and synthetically useful, “drug-like” building... Show more »

Synovel Laboratory LLC is an integrated Contract Research Organization (CRO) of medicinal/process chemistry support for pharmaceutical R&D.

At Synovel Laboratory, we are experienced in drug discovery and development projects either in an early LI (Lead Identification) stage, late LO (Lead Optimization) stage or Pre-IND development stage.

We aim to provide the best drug candidate(s) for your project with the optimized potency; physical chemical properties (eg. aqueous solubility, solid crystallinity); DMPK properties (eg. human microsomal stability, animal in vivo PK) and toxicological liability (eg. CYPs inhibition and induction, hERG inhibition, cytotoxicity).

  • Stemming from our talented synthetic/process chemistry team, we provide a variety of products such as API starting material and intermediates, comprehensive collection of clinical reference compounds and synthetically useful, “drug-like” building blocks for small molecule pharmaceuticals research.
  • From our experienced leadership of medicinal chemistry, we will provide “full service” medicinal chemistry support including compound design, candidates synthesis and medicinal chemistry project consultation, for research organization customers.
  • Our experienced process chemistry team provides development chemistry service, such as process chemistry synthesis optimization, primary salt screening, primary crystal form determination, polymorph analysis and large scale (kg quantity) of non-GMP API intermediate preparation. This will serve the chemistry needs of pharmaceutical companies and small-startups to advance their candidates to IND enables stage.

Recent Publications

  • Hidenori Takahashi; Doris Riether; Alessandra Bartolozzi; Todd Bosanac; Valentina Berger; Ralph Binetti; John Broadwater; Zhidong Chen; Rebecca Crux; Stéphane De Lombaert; Rajvee Dave; Jonathon A. Dines; Tazmeen Fadra-Khan; Adam Flegg; Michael Garrigou; Ming-Hong Hao; John Huber; J. Matthew Hutzler; Steven Kerr; Adrian Kotey; Weimin Liu; Ho Yin Lo; Pui Leng Loke; Paige E. Mahaney; Tina M. Morwick; Spencer Napier; Alan Olague; Edward Pack; Anil K. Padyana; David S. Thomson; Heather Tye; Lifen Wu; Renee M. Zindell; Asitha Abeywardane; Thomas Simpson “Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein Inhibitors: Discovery of 2-[4-(3-{(R)-1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1- cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915)” J. Med. Chem. 2015, 58 (4), 1669-1690.
  • Lo, H. Y.; Nemoto, P. A.; Kim, J. M.; Hao, M-H.; Qian, K. C.; Farrow, N. A.; Albaugh, D. R.; Fowler, D. M.; Schneiderman, R. D.; August, E. M.; Martin, L.; Hill-Drzewi, M.; Pullen, S. R.; Takahashi, H.; De Lombaert, S. “Benzimidazolone as Potent Chymase Inhibitor: Modulation of Reactive Metabolites Formation in the Hydrophobic (P1) Region” Bioorg. Med. Chem. Lett. 2011, 21 (15), 4533- 4539.
  • Ingraham, R. H.; Gless, R. D.; Lo. H. Y. “Soluble Epoxide Hydrolase Inhibitors and their Potential for Treatment of Multiple Pathologic Conditions” Current Medicinal Chemistry, 2011, 18 (4), 587-603.
  • Lo, H. Y.; Man, C. C.; Fleck, R. W.; Farrow, N. A.; Ingraham, R. H.; Kukulka, A.; Proudfoot, J. R.; Betageri, R.; Kirrane, T.; Patel, U.; Sharma, R.; Hoermann, M. A.; Kabecenell, A.; De Lombaert, S. “Substituted pyrazole as novel sEH antagonist: Investigation of key binding interactions within the catalytic domain” Bioorg. Med. Chem. Lett. 2010, 20, 6379-6383.
  • Lo, H. Y. “Itk inhibitors: a patent review” Expert Opin. Ther. Patents 2010, 20(4), 459-469.
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Synovel Laboratory LLC has not listed any services.

Medicinal Chemistry
Price on request
  • Consultation
  • Compound design (New lead identification, SAR exploration, Lead optimization)
  • Compound synthesis
  • Patent protection
  • Flexible way of charge (FTEs or project based)
  • Consultation
  • Compound design (New lead identification, SAR exploration, Lead optimization)
  • Compound synthesis
  • Patent protection
  • Flexible way of charge (FTEs or project based)
« Show less
Compound Synthesis
Price on request
  • Specific synthetic target by request
  • With or without established synthetic route
  • Rapid turnover time with low cost
  • Organic or inorganic compounds syntheses
  • Specific synthetic target by request
  • With or without established synthetic route
  • Rapid turnover time with low cost
  • Organic or inorganic compounds syntheses
« Show less
Drug Discovery
Price on request

—In Synovel Laboratory, we are experienced in drug discovery and development projects either in an early LI (Lead Identification) stage, late LO (Lead Optimization) stage or Pre-IND development stage.

We aim to provide the best drug candidate(s) for your project with the optimized potency; physical chemical properties (eg.... Show more »

—In Synovel Laboratory, we are experienced in drug discovery and development projects either in an early LI (Lead Identification) stage, late LO (Lead Optimization) stage or Pre-IND development stage.

We aim to provide the best drug candidate(s) for your project with the optimized potency; physical chemical properties (eg. aqueous solubility, solid crystallinity); DMPK properties (eg. human microsomal stability, animal in vivo PK) and toxicological liability (eg. CYPs inhibition and induction, hERG inhibition, cytotoxicity).
We have extensive network and alliance companies, which can perform all the drug discovery support analyses as mentioned above.

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Process and Scale-Up Chemistry
Price on request
  • Synthetic routes optimization for lead candidates
  • Non-GMP grade intermediates syntheses
  • Establish GMP production relationship with qualified GMP facilities and streamline the technical transfer process
  • Exploratory salt screening
  • Exploratory crystal form and polymorph analysis
  • Isolation and syntheses of impurities according to CMC regulation for IND submission
  • Synthetic routes optimization for lead candidates
  • Non-GMP grade intermediates syntheses
  • Establish GMP production relationship with qualified GMP facilities and streamline the technical transfer process
  • Exploratory salt screening
  • Exploratory crystal form and polymorph analysis
  • Isolation and syntheses of impurities according to CMC regulation for IND submission
« Show less
ADME and DMPK Studies
Drug Metabolism and Pharmacokinetics
Price on request

• Analytical Method Development HPLC/UV and LCMS Metabolite ID and metabolic stability assessments
• GLP compliance: Custom software and tools for bioanalyis (database development using filemaker pro for tracking functions and sample management)

• Analytical Method Development HPLC/UV and LCMS Metabolite ID and metabolic stability assessments
• GLP compliance: Custom software and tools for bioanalyis (database development using filemaker pro for tracking functions and sample management)

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PK/PD Modeling
Pharmacokinetics/Pharmacodynamics Modeling
Price on request

• Consulting in Pharmacokinetics - code development for PK and statistical evaluation using the R program

• Consulting in Pharmacokinetics - code development for PK and statistical evaluation using the R program

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IND/NDA Submission
Investigational New Drug/New Drug Application Submission
Price on request

• Document preparation for IND, BLA and NDA Submissions.
• Response to queries from regulatory agencies – FDA, EMA, PMDA

• Document preparation for IND, BLA and NDA Submissions.
• Response to queries from regulatory agencies – FDA, EMA, PMDA

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Project Management & Consulting Services
Price on request
Request a quote for more information about this service.
Chemistry and Materials
Price on request
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FDA approval process
Price on request
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Drug Discovery & Development
Price on request
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Regulatory Affairs Services
Price on request
Request a quote for more information about this service.
Pharmacology & Toxicology
Price on request
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Synthetic Chemistry
Price on request
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Contract Research
Price on request
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Cardiovascular Disease
Price on request
Request a quote for more information about this service.
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2018-01-31 10:21:45 -0800

Net Promoter Score of 8 received for Compound Synthesis.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 7.
2018-01-29 06:41:10 -0800

Net Promoter Score of 10 received for Compound Synthesis.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-10-26 11:20:20 -0700

Net Promoter Score of 10 received for Compound Synthesis.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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