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Sussex Research Laboratories, Inc.

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Ottawa, Ontario, CA

About Sussex Research Laboratories, Inc.

Sussex Research, a spin-off of the National Research Council (NRC) of Canada, is highly equipped and well versed in carbohydrate synthesis. As a specialist in glycodesign and the synthesis of complex carbohydrate systems, we excel at discovery and development of molecules that explore and exploit glycobiology or incorporate glycotechnology. Our unique product portfolio and synthetic capabilities enable researchers across many scientific disciplines to readily explore glycotechnology to advance drug discovery & development, drug delivery, enhance therapeutic outcomes of lead molecules or develop new glycoconjugate or polysaccharide vaccines.

Carbohydrate Product Portfolio. We offer a portfolio of diverse carbohydrate-based products and are highly active in custom synthesis and contract manufacture of oligosaccharides, glycosaminoglycans, glycoamino acids, glycopeptides, carbohydrate ligands and a wide variety of synthetic building blocks.

Custom Synthesis: Sussex Research specializes in offering responsive, flexible and timely non-GMP synthetic, analytical and bioanalytical services backed by a full arsenal of analytical techniques including high resolution NMR, Mass Spectrometry, LC-MS, HPLC, SEC-HPLC, SDS-PAGE.

Contract Research - Our advanced capabilities in carbohydrate synthetic chemistry, purification and characterization has benefited our collaborators in academia, research institutions, biotechnology and pharma at all stages of research & development from basic research to clinical trials. Our major contract research efforts have ranged from synthesis of discrete small molecule heparin up to 8 units to drug glycotargeting to development of multi-serotype polysaccharide conjugate vaccines.

Stable Isotope-Labeling: Sussex Research has developed special expertise in the area of stable isotope-labeling (2H, 13C and 15N) of API, vitamins, metabolites and other small molecules.

Analytical Services – Sussex Research’s Glycoanalysis capabilities draw on its extensive experience in high-resolution and solid-state Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS) and leading expertise in the purification and chemical characterization of carbohydrates.

Recent Publications

  • Dennis M. Whitfield & Jiatong Guo, "Proton transfer and hydrogen bonding in glycosylation reactions" Journal of Carbohydrate Chemistry 2017, 36:2-3, 59-99.
  • Allison E. Kennedy, et al. “Nerve growth factor inhibitor with novel-binding domain demonstrates nanomolar efficacy in both cell-based and cell-free assay systems” Pharmacol Res Perspect. 2017, 5(5).
  • Allison E. Kennedy, et al. “Effects of serum albumin on SPR-measured affinity of small molecule inhibitors binding to nerve growth factor” Sensing and Bio-Sensing Research 2017, 15, 1–4.
  • Kristen S.A. Sheffield, et al. “Using surface plasmon resonance spectroscopy to characterize the inhibition of NGF-p75NTRand proNGF-p75NTRinteractions by small molecule inhibitors” Pharmacological Research 2016, 103, 292–299.
  • Allison E. Kennedy, et al. “A Surface Plasmon Resonance Spectroscopy Method for Characterizing Small-Molecule Binding to Nerve Growth Factor” Journal of Biomolecular Screening 2015, 21(1), 96-100.
  • Mohamed I. Hassan, et al. "Total Biosynthesis of Legionaminic Acid, a Bacterial Sialic Acid Analogue" Angew. Chem. Int. Ed. 2016, 55, 12018.
  • R. Yalagala, et al., "Microwave assisted synthesis of BODIPY-sugar conjugates through the Click chemistry and assembly of the conjugate into bilayers" Carbohydrate Res. 2016, 424, 15.
  • H. Yan, et al. "Fluorescently labelled glycans and their applications" Glycoconjug. J. 2015, 32, 559.

Our Services (23)


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Chemical Synthesis

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Sussex Research is known worldwide for its custom synthesis and contract R&D capabilities which utilize our core expertise in carbohydrate synthesis and method development. We provide custom synthesis solutions for biopharmaceutical, therapeutic, diagnostic and research applications for development of molecules that incorporate glycotechnology or exploit glycobiology. We excel at oligosaccharide, glycopeptide and glycoconjugate synthesis. All materials produced at Sussex are thoroughly analyzed and characterized on-site via a variety of state-of-the-art spectroscopic techniques including high field NMR and mass spectrometry.

Sussex Research specializes in multi-step custom synthesis for researchers. We welcome projects which utilize our core expertise in carbohydrate synthesis.

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Mass Spectrometry

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NMR

Nuclear magnetic resonance spectroscopy
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FT-IR

Fourier transform infrared spectroscopy
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HPLC

High Performance Liquid Chromatography
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Structure Determination

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Sussex Research offers comprehensive services for structural analysis of carbohydrates.

Our Glycoanalysis Laboratory draws on its extensive experience in high-resolution and solid-state Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS) and leading expertise in the purification and chemical characterization of glycans.


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LC-MS

Liquid Chromatography-Coupled Mass Spectrometry
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LC-MS/MS

Liquid chromatography tandem mass spectrometry
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Plasma Bioanalysis

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Project Management

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Liquid Chromatography Coupled Mass Spectrometry Methods

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Infrared Spectroscopy Services

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Bioanalysis

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Pharmacology & Toxicology

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Analytical Chemistry Services

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Spectroscopy

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Liquid Chromatography (LC)

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Chemistry and Materials

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Synthetic Chemistry

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Separation/Purification Services

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Chromatography

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Imaging & Spectroscopy

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Assay Development

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Brady Clark

President & CEO

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