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Structural Biology Facility (DFCI)

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Boston, Massachusetts, US

About Structural Biology Facility (DFCI)

Our laboratory answers biochemical and structural biology questions in fields related to cancer research with a focus on transcriptional and translational cellular processes. We believe that a better molecular and structural understanding of these processes will reveal novel cancer drug targets. We therefore generate high quality protein reagents and conduct biophysical, biochemical, and structural characterization experiments to uncover novel mechanisms of action. And within integrated teams of clinicians, biologists, and chemists, we perform in-vitro studies that facilitate development of novel chemical probes, tool compounds, and drug therapies. If you are looking for a partner and collaborator on your mechanism- or therapeutic-focused project, don't hesitate to contact us.

Our Services (5)


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Crystal Structure Determination

Price on request

Crystal screening, optimization, and harvesting.  Data-collection, data-processing, phasing, structure refinement, and PDB deposition.

Gene-to-Protein-to-Assay-to-Structure


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Recombinant Protein Expression

Price on request

Bacterial (E. coli) and Baculoviral (Sf9 and Hi5) expressions, from 1 to 10 liter scale


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Protein Purification

Price on request

Milligram-scale, FPLC-based affinity chromatography (Nickle-, Flag-, and Maltose-based resins), ion-echange, chromatography (Mono-Q or -S), and size-exclusion chromatography (Superdex-75 or -200).


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Protein Biophysical Characterization

Price on request

Isothermal Titration Calorimetry (ITC), thermal stabilization assay (TSA), differential scanning fluorimetry (DSF),  Circular Dichroism (CD), Dynamic Light Scattering (DLS). Fluorescence Polarization (FP), Fluorescence Resonance Energy Transfer, Time-Resolved (tr-FRET), and ADPGlo.

See this link for options: https://www.dhepaglab.org/data/b2efaeed.html


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Gene-to-Protein Services

Price on request
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Sirano Dhe-Paganon

Lead Scientist

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