The primary mission of the Structural Biology Facility is to provide state-of-the-art equipment, training, technical support and maintenance of equipment indispensable for structural biologists and other researchers studying the structures of biological macromolecules and materials. The facility also provides structure determination and data collection services, both for crystallography and cryoEM.
The facility plays an essential role in the research programs of investigators who are studying the relationship between macromolecular structure and function, using macromolecular structure as the starting point for structure-based drug design, or needing to characterize complex biomaterials. It is a unique resource at Northwestern University that capitalizes on the extensive expertise of its facility managers to provide access and support for experiments using the synchrotron radiation X-ray source at the Life Sciences Collaborative Access Team (LS-CAT) beamlines at the Advanced Photon Source (APS) at Argonne National Laboratory and state-of-the-art electron microscopes and detectors, suitable for atomic-level structural studies by CryoEM on the Evanston campus.
In addition, the facility provides crystallization robots and microscopes for analyzing crystallization experiments, all the equipment for sample preparation for EM studies and computational resources for analyzing data produced by a wide range of experimental approaches — including crystallography, electron microscopy and NMR — together with computational tools for modeling and design studies.
Biochemistry & Molecular Biology Services
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