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Stemina Biomarker Discovery

Madison, Wisconsin, US

Stemina Biomarker Discovery develops and commercializes molecular biomarkers to improve drug safety and human health.

The company opened in November 2007 in Madison, Wisconsin. Stemina’s technology arises from the strategic convergence of two cutting edge technologies, stem cells and metabolomics. The team has grown by adding very skilled staff and continues to expand with newer efforts directed toward discovery of novel diagnostic biomarkers with projects in autism and other neurological disorders as well as reproductive biology.

Stemina’s technology is focused around several highly specialized technologies that come together in a seamless workflow. A deep understanding of the biological systems in which we work, the analytical methods used to identify and quantify large numbers of relevant biomarkers, and the informatics used to process and assimilate the biological fingerprints are brought together through a... Show more »

Stemina Biomarker Discovery develops and commercializes molecular biomarkers to improve drug safety and human health.

The company opened in November 2007 in Madison, Wisconsin. Stemina’s technology arises from the strategic convergence of two cutting edge technologies, stem cells and metabolomics. The team has grown by adding very skilled staff and continues to expand with newer efforts directed toward discovery of novel diagnostic biomarkers with projects in autism and other neurological disorders as well as reproductive biology.

Stemina’s technology is focused around several highly specialized technologies that come together in a seamless workflow. A deep understanding of the biological systems in which we work, the analytical methods used to identify and quantify large numbers of relevant biomarkers, and the informatics used to process and assimilate the biological fingerprints are brought together through a custom Laboratory Information Management System (LIMS). Experimental design and quality are just two of the factors we consider carefully in every study. At each step of the way, we have integrated key quality criteria that are assessed by an expert scientist to assure the best possible result.

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Non-Targeted Metabolomics
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Clinical Biomarkers
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Biomarker Discovery
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Metabolomics
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Stemina Biomarker Discovery offers a broad suite of metabolomic services focused on identifying metabolites and biomarkers of many biological processes. By focusing on the small molecules, either secreted or consumed by cells, the metabolomics platform is capable of identifying metabolite patterns associated with toxicology,... Show more »

Stemina Biomarker Discovery offers a broad suite of metabolomic services focused on identifying metabolites and biomarkers of many biological processes. By focusing on the small molecules, either secreted or consumed by cells, the metabolomics platform is capable of identifying metabolite patterns associated with toxicology, cellular response to drugs or chemicals, or biomarkers associated with disease.

Our team has experience in working with a spectrum of clients that include pharmaceutical, chemical, agricultural, and cosmetics companies. In addition to the identification of biomarkers, Stemina’s proprietary metabolomics database maps significantly changed small molecules to the molecular pathways in which they reside. The workflow begins with biological sample acquisition, sample preparation and evaluation by high performance liquid chromatography coupled to high resolution mass spectrometry, followed by univariate and multivariate bioinformatic analysis, data mining, evaluation, and interpretation.

Experience counts:

We routinely analyze materials and supernatant from cell culture, human tissue and body fluids. Our team has extensive experience in metabolomic analysis with a specialization in the use of human derived stem cells for performing many of these tests. We routinely conduct studies in embryonic stem (hES) cells, induced pluripotent stem (iPS) cells, as well as a variety of cell types based on selective differentiation into cells such as cardiomyocytes.

Our expertise in human sample analysis includes blood and urine. We have strength in analyzing samples to identify biomarkers associated with neurological disorders. Our seminal study in autism spectrum disorders (ASD) and other neuro-developmental disorders, the Children's Autism Metabolome Project (CAMP), is ongoing at 8 sites across the country. The CAMP study will validate metabolomics biomarkers of subtypes of ASD to allow earlier diagnosis and more precise treatment of children on the spectrum. This expertise can assist in drug development by identifying targets and mechanisms for new therapies as well as identifying who is a responder to the potential therapy.

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Cell Viability Assays
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Drug Candidate Safety Testing
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Developmental Toxicity Screening in Human Stem Cells
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Driven by a need to improve the science and predictive accuracy of known compound and drug candidate toxicity on the developing human embryo, Stemina Biomarker Discovery offers two innovative assay choices: devTOX Discovery and devTOX quickPredict. The assays are based on human pluripotent stem (hPS) cells: devTOX quickPredict... Show more »

Driven by a need to improve the science and predictive accuracy of known compound and drug candidate toxicity on the developing human embryo, Stemina Biomarker Discovery offers two innovative assay choices: devTOX Discovery and devTOX quickPredict. The assays are based on human pluripotent stem (hPS) cells: devTOX quickPredict rapidly predicts the developmental toxicity potential of test articles using the biomarkers ornithine and cystine, and devTOX Discovery, identifies changes in metabolites secreted by hPS cells in response to the test article to help identify mechanisms of toxicity. Each is available using human embryonic stem (hES) and induced pluripotent stem (iPS) cells. Both technologies provide a robust and reproducible, proprietary, all-human system for reducing and replacing animal testing.

The only all-human based screen for assessing the toxicity of drugs and chemical compounds on human development. Stemina's devTOX assays are used by major pharmaceutical, agri-chemical, cosmetics and tobacco companies to assess the risk of developmental toxicity. Stemina is an EPA contractor for ToxCast and has extensive data on more than 1,000 compounds tested in its devTOX assays.

devTOX is highly predictive, quick and requires very little compound.

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Cell Viability & Proliferation Assays
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Biomarkers
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Biology
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Antibody/Antigen Detection Based Testing
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In vitro Toxicity Testing
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Clinical Research
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Clinical Laboratory Services
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Omics
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Toxicology
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Pharmacology & Toxicology
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Safety Pharmacology & Efficacy Testing
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Cell-Based Assays
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Bioanalysis
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Clinical Chemistry
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