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Stem Cell and Xenograft Core

Philadelphia, Pennsylvania, US

The Stem Cell and Xenograft Core (SCXC) is a comprehensive resource laboratory that integrates a viable tissue bank of normal human hematopoietic cells and hematopoietic malignancies with a full range of xenograft services.

The SCXC is committed to facilitating and promoting translational research involving viable primary human hematopoietic tissues. Our core offers adult whole bone marrow from healthy donors and umbilical cord blood. Mononuclear and CD34+ cells from normal bone marrow and cord blood are available, and other cell fractions can be provided by arrangement. We maintain a large tissue bank of cells from hematopoietic malignancies including AML, ALL, CML, MDS and MPDs. All samples are fully annotated and frozen as viable cells. We also offer access to an immunomagnetic cell sorter (Miltneyi AutoMacs). Expertise in primary human hematopoietic stem/progenitor and leukemic cell culture and manipulation is... Show more »

The Stem Cell and Xenograft Core (SCXC) is a comprehensive resource laboratory that integrates a viable tissue bank of normal human hematopoietic cells and hematopoietic malignancies with a full range of xenograft services.

The SCXC is committed to facilitating and promoting translational research involving viable primary human hematopoietic tissues. Our core offers adult whole bone marrow from healthy donors and umbilical cord blood. Mononuclear and CD34+ cells from normal bone marrow and cord blood are available, and other cell fractions can be provided by arrangement. We maintain a large tissue bank of cells from hematopoietic malignancies including AML, ALL, CML, MDS and MPDs. All samples are fully annotated and frozen as viable cells. We also offer access to an immunomagnetic cell sorter (Miltneyi AutoMacs). Expertise in primary human hematopoietic stem/progenitor and leukemic cell culture and manipulation is available. For consultation or questions, please contact Martin Carroll.

The SCXC offers a wide variety of xenograft services from training to full-service experiments. The Core maintains a large breeding colony of immune-deficient (NSG) mice for users' xenograft studies. We also offer human immune system (CD34-transplanted) NSG mice for a wide variety of studies ranging from gene therapy to HIV. Experimental animals are housed in dedicated BSL-2 animal barrier space equipped for whole body irradiation and all necessary procedures and survival surgeries. Currently established xenograft models include normal human CD34 and leukemia engraftment, human iPS and ES-derived teratomas, human skin grafting, orthotopic human ovarian, hepatic and pancreatic tumor cell injections, renal capsule implantation. We also offer access to a dedicated optical/fluorescence (IVIS Spectrum) imaging system located within the Core's BSL-2 space.

Certifications:
BSL-2

Relevant publications:
- Chacko AM, Li C, Pryma DA, Brem S, Coukos G, Muzykantov V: Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood-brain barrier divide. Expert opinion on drug delivery 2013, 10(7):907-926.
- de Pater E, Kaimakis P, Vink CS, Yokomizo T, Yamada-Inagawa T, van der Linden R, Kartalaei PS, Camper SA, Speck N, Dzierzak E: Gata2 is required for HSC generation and survival. The Journal of experimental medicine 2013, 210(13):2843-2850.
- Didigu CA, Wilen CB, Wang J, Duong J, Secreto AJ, Danet-Desnoyers GA, Riley JL, Gregory PD, June CH, Holmes MC et al: Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection. Blood 2014, 123(1):61-69.

Standard sample shipment requests:
Next Day Air for banked samples

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Stem Cell and Xenograft Core has not listed any services.

Human Biospecimens
Price on request
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Human
hematology
Acute Myeloid Leukemia (AML)
Acute Lymphocytic Leukemia (ALL)
Chronic Myelogenous Leukemia (CML)
MDS
MPD
Human Tumor Xenograft Models
Starting at $140.00 per animal
  • Busulfan conditioning $60.00
  • Irradiation (gamma source) $20.00
  • Retro-orbital bleed $30.00
  • Injection (iv, ip, sc) $30.00
  • Intra-femoral injection $80.00
  • Intra-cranial injection (stereotaxic) $140.00
  • Intra-hepatic injection $120.00
  • Intra-ovarian injection $120.00
  • Intra-pancreatic injection... Show more »
  • Busulfan conditioning $60.00
  • Irradiation (gamma source) $20.00
  • Retro-orbital bleed $30.00
  • Injection (iv, ip, sc) $30.00
  • Intra-femoral injection $80.00
  • Intra-cranial injection (stereotaxic) $140.00
  • Intra-hepatic injection $120.00
  • Intra-ovarian injection $120.00
  • Intra-pancreatic injection $120.00
  • Lung injection (trans-pleural) $120.00
  • Renal capsule implantation $130.00
  • Mouse body scoring $20.00
  • Mouse bone marrow aspirate $80.00
  • Mouse health monitoring (per cage) $10.00
  • Mouse weighing $20.00
  • Oral gavage $20.00
  • Osmotic pump implantation (pump not included) $50.00
  • Topical drug application $30.00
  • Tumor measurements (caliper) $20.00
  • Blood glucose measurements $30.00
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Cryopreserved Human CD34+ Cells
Starting at $1,000.00 per sample
  • Adult bone marrow mononuclear cells (per million) $22
  • Adult bone marrow CD34+ cells (per million) $900
  • Umbilical cord blood mononuclear cells (per million) $20
  • Umbilical cord blood CD34+ cells (per million) $1000
  • Adult bone marrow mononuclear cells (per million) $22
  • Adult bone marrow CD34+ cells (per million) $900
  • Umbilical cord blood mononuclear cells (per million) $20
  • Umbilical cord blood CD34+ cells (per million) $1000
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Humanized Mouse Models
Starting at $750.00 per animal
  • CD34+ transplanted mice $560

  • Fetal CD34+ cells and autologous thymus transplanted (BLT) mice $750

  • CD34+ transplanted mice $560

  • Fetal CD34+ cells and autologous thymus transplanted (BLT) mice $750

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Cryopreserved hematologic malignancy patient sample
Starting at $900.00 per sample
  • Patient specimen-MNC (per vial) $600.00
  • Patient specimen (proven to engraft in NSG mice) $900.00
  • Patient specimen-MNC (per vial) $600.00
  • Patient specimen (proven to engraft in NSG mice) $900.00
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Immunodeficient Animal Models
Starting at $160.00 per animal
  • NOD-Scid-IL2Rgc null (NSG) mice $160
  • Hu IL-3, GM-CSF, SCF-NSG (NSG-S) mice $160
  • NOD-Scid-IL2Rgc null (NSG) mice $160
  • Hu IL-3, GM-CSF, SCF-NSG (NSG-S) mice $160
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Animal Models and Studies
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Cell Lines
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Oncology Animal Models
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Animal Models of Disease
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Biology
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Cells and Tissues
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Biospecimens
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Immunology Animal Models
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Xenograft Models
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2018-01-25 14:59:02 -0800

Net Promoter Score of 9 received for Human Biospecimens.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.

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