Kybrhr1sfa93c0cxyopx screen shot 2017 04 17 at 11.54.54 am

Stable Isotope and Metabolomics Core

Bronx, NY, US

Metabolomics is the global profiling of small metabolites such as amino acids, glycolytic, TCA and pentose cycle metabolites, and in combination with lipidomics (fatty acids, acyl carntines, phospholipids, di- and tri-glycerides) presents a powerful approach to functional biology for biomedical, clinical questions. Fluxomics uses stable isotopes to assess intra- and inter-organ flux. Use of fluxomics combined with metabolomics yields a comprehensive picture of metabolic regulation, and how its is impacted by disease.

The newly established Einstein Stable Isotope & Metabolomics Core (SIMC) uses stable isotope flux and metabolite profiling to help formulate and test hypotheses about the metabolic consequences of various changes in gene expression and protein function, in order to guide further integrative systems biology analyses of the underlying mechanisms in diabetes, insulin resistance, obesity, and diabetic... Show more »

Metabolomics is the global profiling of small metabolites such as amino acids, glycolytic, TCA and pentose cycle metabolites, and in combination with lipidomics (fatty acids, acyl carntines, phospholipids, di- and tri-glycerides) presents a powerful approach to functional biology for biomedical, clinical questions. Fluxomics uses stable isotopes to assess intra- and inter-organ flux. Use of fluxomics combined with metabolomics yields a comprehensive picture of metabolic regulation, and how its is impacted by disease.

The newly established Einstein Stable Isotope & Metabolomics Core (SIMC) uses stable isotope flux and metabolite profiling to help formulate and test hypotheses about the metabolic consequences of various changes in gene expression and protein function, in order to guide further integrative systems biology analyses of the underlying mechanisms in diabetes, insulin resistance, obesity, and diabetic complications. The SIMC Facility is a nonprofit organization established at the Einstein Diabetes Center. It is designed to provide services on the recharge basis. SIMC’s evaluation framework complements the analyses performed in the Animal Physiology Core, such as measurements of whole body carbohydrate/fatty acid oxidation, energy expenditure, tissue-specific insulin sensitivity, glucose, protein and fatty acid metabolism.

Recent Publications

  • Y. Qiu et al., Isotopic Ratio Outlier Analysis (IROA) of the S. cerevisiae metabolome using accurate mass GC-TOF/MS: A new method for discovery. Analytical Chemistry, (2015) Accepted manuscript
  • X. Liu et al., The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif. Cell Reports 13, 2219-2231 (2015).
  • N. Bonhoure et al., Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Genes & Development 29, 934-947 (2015).
  • W. Brima et al., The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD-1 mice. Diabetes-Metabolism Research and Reviews 31, 346-359 (2015).
  • P. O. Broin et al., Intestinal Microbiota-Derived Metabolomic Blood Plasma Markers for Prior Radiation Injury. International Journal of Radiation Oncology Biology Physics 91, 360-367 (2015).
  • J. Jao et al., Lower Preprandial Insulin and Altered Fuel Use in HIV/Antiretroviral-Exposed Infants in Cameroon. Journal of Clinical Endocrinology & Metabolism100, 3260-3269 (2015).
  • I. J. Kurland et al., Integrative Metabolic Signatures for Hepatic Radiation Injury. Plos One 10, (2015).
  • J. Miao et al., Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins. Journal of Lipid Research 55, 659-667 (2014).
  • R. A. Haeusler et al., Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors. Nature Communications 5, (2014).
  • K. Nowak et al., Metabolomics Profiles Suggest a Mechanism for Caloric Restriction-Induced Radiation Sensitivity. International Journal of Radiation Oncology Biology Physics 90, S176-S177 (2014).
  • B. Vaitheesvaran et al., Role of the tumor suppressor IQGAP2 in metabolic homeostasis: possible link between diabetes and cancer. Metabolomics 10, 920-937 (2014).
« Show less

Stable Isotope and Metabolomics Core has not listed any services.

Metabolite Profiling
Price on request

Assessments of plasma and tissue metabolite profiles for diagnosis/characterization of physiological and pathophysiological states. These include key metabolites in the glycolytic, gluconeogenic, pentose phosphate, and tricarboxylic (TCA) cycle pathways, fatty acid oxidation and complex lipids.

Assessments of plasma and tissue metabolite profiles for diagnosis/characterization of physiological and pathophysiological states. These include key metabolites in the glycolytic, gluconeogenic, pentose phosphate, and tricarboxylic (TCA) cycle pathways, fatty acid oxidation and complex lipids.

« Show less
Stable Isotope Analysis
Price on request

In vivo stable isotope substrate flux assays to determine rates of protein synthesis, lipogenesis and peripheral glucose disposal.

In vivo stable isotope substrate flux assays to determine rates of protein synthesis, lipogenesis and peripheral glucose disposal.

« Show less
Cellular Bioenergetics
Price on request

In vitro assessments of glycolysis (extracellular acidification rates) and mitochondrial oxygen consumption (mitochondrial respiration) in tissue explants, primary isolated and tissue culture cells using Seahorse Biosciences Flux Analyzers.

In vitro assessments of glycolysis (extracellular acidification rates) and mitochondrial oxygen consumption (mitochondrial respiration) in tissue explants, primary isolated and tissue culture cells using Seahorse Biosciences Flux Analyzers.

« Show less
Agilent Seahorse XF Analyzer
Mass Spectrometry
Price on request
Request a quote for more information about this service.
Spectroscopy
Price on request
Request a quote for more information about this service.
Omics
Price on request
Request a quote for more information about this service.
Cell-Based Assays
Price on request
Request a quote for more information about this service.
Biology
Price on request
Request a quote for more information about this service.
Imaging & Spectroscopy
Price on request
Request a quote for more information about this service.
Cellular Health & Metabolism Assays
Price on request
Request a quote for more information about this service.
Specialty Mass Spectrometry Methods
Price on request
Request a quote for more information about this service.
Metabolomics
Price on request
Request a quote for more information about this service.
Ask A Question Find what you're looking for? If not, you can ask this lab a question:
2017-09-04 07:02:34 -0700

Net Promoter Score of 9 received for Metabolomics.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.

Be the first to endorse Stable Isotope and Metabolomics Core

Endorse this lab