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Spirovation

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Chapel Hill, North Carolina, US

About Spirovation

Founded: 2013 Type: Nonprofit Size: 1-10 employees

Spirovation is specialty CRO affiliated with the Marsico Lung Insitute at the University of North Carolina at Chapel Hill, combining world-class academic scientific leadership with the operational capabilities of a contract research organization. Our mission is to empower breakthrough drug development in... Show more »

Spirovation is specialty CRO affiliated with the Marsico Lung Insitute at the University of North Carolina at Chapel Hill, combining world-class academic scientific leadership with the operational capabilities of a contract research organization. Our mission is to empower breakthrough drug development in respiratory medicine by providing leading scientific expertise and the broadest array of translational medicine capabilities in respiratory research.

Spirovation understands capital efficiency. We work with our partners to identify, design and execute joint research activities more efficiently and more strategically so that milestones are met as quickly and efficiently as possible. Our standard and proprietary assays support customized drug discovery and translational medicine to meet the unique needs of small, medium, and large biopharmaceutical companies.

Commitment to Customers

  • Alignment of goals, incentives, processes and working practices
  • Fast and easy contracting
  • Integrated project management across labs
  • High quality deliverables
  • Cost effective

Scientific Leadership

  • State-of-the-art research models, many unique
  • Unrivaled expertise and resources in respiratory medicine
  • Full cascade of mechanistic and functional studies from early screening through Phase 2a clinical trials
  • Publication record impacting respiratory science
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Our Services (97)


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Phase II Clinical Trials

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Respiratory

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Single Cell Isolation

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Phase I Clinical Trials

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Respiratory

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Cell Viability Assays

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Scanning Electron Microscopy (SEM)

Scanning Electron Microscopy services
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The histology core provides expertise in all aspects of transmission and scanning electron microscopy. Access to a high pressure freezer and automated freeze substitution is available.

The histology core provides expertise in all aspects of transmission and scanning electron microscopy. Access to a high pressure freezer and automated freeze substitution is available.

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Biomarker Discovery

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Novel Biomarkers for Pulmonary Drug Development

  • Novel biomarkers for measuring the pharmacodynamic and therapeutic effects of inhaled therapeutic agents in sputum
  • Measures of absolute mucin concentrations, mucin/mucus osmotic pressure/modulus, and measures of mucus adhesion in induced or spontaneously expectorated... Show more »

Novel Biomarkers for Pulmonary Drug Development

  • Novel biomarkers for measuring the pharmacodynamic and therapeutic effects of inhaled therapeutic agents in sputum
  • Measures of absolute mucin concentrations, mucin/mucus osmotic pressure/modulus, and measures of mucus adhesion in induced or spontaneously expectorated sputum
  • The Sputum Core measures cell counts, cytokines, and growth factors in sputum and BAL
  • Resources, including the Sputum Core, for development of novel biomarkers for pulmonary drug development
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Paraffin Sectioning

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Histology and Pathology Services

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The Histology Core provides high quality light and electron microscopy services:

  • Light microscopy services include: prosection, tissue fixation, processing, embedding, sectioning, staining and cover slipping of paraffin, frozen and soft plastic tissue sections.
  • The histology core also provides expertise in all aspects of... Show more »

The Histology Core provides high quality light and electron microscopy services:

  • Light microscopy services include: prosection, tissue fixation, processing, embedding, sectioning, staining and cover slipping of paraffin, frozen and soft plastic tissue sections.
  • The histology core also provides expertise in all aspects of transmission and scanning electron microscopy. Access to a high pressure freezer and automated freeze substitution is available.
  • A highlight of the core facility is our specialized procedure for histological evaluation of airway cells grown on porous membrane supports.
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RNA Extraction and Purification

Price on request

Isolation, storage, and analysis of high quality RNA.

Isolation, storage, and analysis of high quality RNA.

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Clinical Trial Design and Consulting

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PK, target engagement, initial clinical benefit/ risk

PK, target engagement, initial clinical benefit/ risk

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Pannexin -/- Mouse Model

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βENaC Transgenic Mouse Model

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P2Y4-R -/- Mouse Model

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P2Y2-R -/- Mouse Model

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MUC16 -/- Mouse Model

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MUC4 -/- Mouse Model

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MUC1 -/- Mouse Model

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Cystic Fibrosis Animal Models

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We offer numerous animal models of lung diseases, including the first “CF mouse” (UNCtm null).

We offer numerous animal models of lung diseases, including the first “CF mouse” (UNCtm null).

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Mouse

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Genetically Engineered Mice

Price on request

The Mouse Models Core Laboratory operates under the supervision of Dr. Wanda O’Neal and is dedicated to in vivo studies involving transgenic and knock-out mice generated or procured through the Marsico Lung Institute.

Capabilities

  • Generation and characterization of congenic βENaC -Tg lines (in C57BL6N, C3H/HeN, BALBc/J,... Show more »

The Mouse Models Core Laboratory operates under the supervision of Dr. Wanda O’Neal and is dedicated to in vivo studies involving transgenic and knock-out mice generated or procured through the Marsico Lung Institute.

Capabilities

  • Generation and characterization of congenic βENaC -Tg lines (in C57BL6N, C3H/HeN, BALBc/J, FVB/NJ, 129/Sv genetic backgrounds).
  • Transgenic lines that overexpress different combinations of ENaC subunits (a and/or β and/or g).
  • Transgenic lines that overexpress low amount of βENaC transgene (low-overexpressor line).
    Crossings of βENaC-Tg mice with selected gene-deleted mice (TNFa, IL-4Ra, MyD88, TLR2, TLR4, Muc1, Muc 4, Muc16, Muc5ac, Muc5b, CFTRDF508, NLRP3).
  • Administration of pharmacologic treatments aimed at preventing and/or blunting the insurgence of obstructing lung pathology.
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Cell Line Generation

Price on request

Use recent advances in cell immortalization technology to create new cell lines and characterize their biochemical properties, morphology and electrophysiologic function

Use recent advances in cell immortalization technology to create new cell lines and characterize their biochemical properties, morphology and electrophysiologic function

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Human Tissue Procurement

Price on request

Obtain nasal tissues and tracheo-bronchiolar segments from normal, CF and disease control humans as sources of airway epithelial cells for culture, for ex vivo experiments, for RNA and proteins representative of in vivo conditions, and for in situ hybridization and immunohistochemistry

Obtain nasal tissues and tracheo-bronchiolar segments from normal, CF and disease control humans as sources of airway epithelial cells for culture, for ex vivo experiments, for RNA and proteins representative of in vivo conditions, and for in situ hybridization and immunohistochemistry

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Image Analysis

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Confocal Microscopy

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Bright-Field Microscopy

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Western Blot

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Northern Blot

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Live Cell Imaging

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Southern Blot

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RT-PCR

Reverse transcription polymerase chain reaction
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qPCR

Quantitative PCR
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PCR

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Mucositis Animal Models

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Pulmonary Inflammation Animal Models

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Mouse

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Pneumonia Animal Models

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Drug Target Validation

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  • Innovative animal models and in vitro models utilizing patient-derived materials
  • Expertise in pathobiology of disease, enabling a pathway-based approach to target ID/ validation
  • Innovative animal models and in vitro models utilizing patient-derived materials
  • Expertise in pathobiology of disease, enabling a pathway-based approach to target ID/ validation
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COPD Animal Models

Chronic Obstructive Pulmonary Disease Animal Models
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Drug Target Identification

Price on request
  • Innovative animal models and in vitro models utilizing patient-derived materials
  • Expertise in pathobiology of disease, enabling a pathway-based approach to target ID/ validation
  • Innovative animal models and in vitro models utilizing patient-derived materials
  • Expertise in pathobiology of disease, enabling a pathway-based approach to target ID/ validation
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Sepsis Animal Models

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Mouse

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Electrophysiology Animal Models

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Ussing chamber ion current measurement in bronchial and GI epithelial cells

We have extensive capabilities to perform classical Ussing chamber studies on large numbers of tissues for screening purposes. Extensive experience has accrued in developing the appropriate quality control procedures to assure accurate and reproducible testing of compound activities in this assay

Ussing chamber ion current measurement in bronchial and GI epithelial cells

We have extensive capabilities to perform classical Ussing chamber studies on large numbers of tissues for screening purposes. Extensive experience has accrued in developing the appropriate quality control procedures to assure accurate and reproducible testing of compound activities in this assay

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Acute Lung Injury Animal Models

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Mouse

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Compound Profiling

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Southwestern Blot

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Ciliary Motility Assay

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We offer an extensive array of technologies to measure ciliary function both in vitro and in vivo. Thus, we have available techniques for measurement of ciliary beat frequency in human and animal culture systems, measurements with high-speed videomicroscopy of ciliary beat form, ultrastructural measurement capacities to evaluate... Show more »

We offer an extensive array of technologies to measure ciliary function both in vitro and in vivo. Thus, we have available techniques for measurement of ciliary beat frequency in human and animal culture systems, measurements with high-speed videomicroscopy of ciliary beat form, ultrastructural measurement capacities to evaluate ciliary shaft structure, and the ability to perform proteomics of ciliary shaft proteins.

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Mucin Secretion Assays

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We have extensive experience with cell culture and freshly excised murine tracheal models to measure baseline and regulated mucin secretion. These models are coupled to a spectrum of mucin measurement technologies, including antibody/ELISA based, biochemical/UPLC - light scattering technologies, and techniques that couple both... Show more »

We have extensive experience with cell culture and freshly excised murine tracheal models to measure baseline and regulated mucin secretion. These models are coupled to a spectrum of mucin measurement technologies, including antibody/ELISA based, biochemical/UPLC - light scattering technologies, and techniques that couple both technologies.

In addition, we have extensive experience in measuring biophysical properties of mucus that are important for drug penetration through mucus, mucus flow, and mucus adhesion.

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Airway Surface Liquid Depth Measurement

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We have extensive experience in characterizing airway surface liquid physiology, in response to candidate therapeutic agents, under the “thin film” ASL technique. In “standard” versions of this technique, a combination of airway surface liquid (ASL) volume as measured by confocal techniques, indices of ion transport processes... Show more »

We have extensive experience in characterizing airway surface liquid physiology, in response to candidate therapeutic agents, under the “thin film” ASL technique. In “standard” versions of this technique, a combination of airway surface liquid (ASL) volume as measured by confocal techniques, indices of ion transport processes mediating ASL volume homeostasis from transepithelial microelectrode voltage measurements, coupled with micropipette liquid sampling for measurements of drug concentrations, can be made. Note, drugs can be added to the basolateral compartment of these preparations, the luminal compartment in perfluorocarbon, or indeed, more recently, by an interface to ultrasonic nebulizers that deliver aerosols to cultured airway surfaces at rates that mimic aerosol deposition in vivo.

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Model Organisms

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Computational Modeling

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Immunology Animal Models

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Cell Viability & Proliferation Assays

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Electron Microscopy

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Clinical Trials, Consulting, and Management

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Lead Identification and Validation

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Genetic Engineering

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RNA Services

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Nucleic Acid Services

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Clinical Laboratory Services

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Infectious Disease Animal Models

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Biospecimens

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DNA Services

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Drug Discovery & Development

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Animal Models of Disease

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Mouse Models

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Cell and Tissue Culture

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CNS/Neurology Animal Models

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Transgenic Mouse Services

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Microscopy

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Ex Vivo Models and Assays

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Biomarkers

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Optical Microscopy

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Respiratory Disease Animal Models

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Rodent Models

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Animal Models and Studies

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Biology

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Functional & Cell Type Specific Assays

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Protein Services

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Transgenic Animal Model Development

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Protein Expression Visualization

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DNA Fragment Analysis

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Cells and Tissues

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Tissue Processing

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Inflammation Animal Models

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Mammalian Models

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Fluorescence-Based Microscopy

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Human Biospecimen Collection

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Clinical and Anatomic Pathology

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Imaging & Spectroscopy

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Biochemistry & Molecular Biology

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Cell-Based Assays

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Clinical Research

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Pharmacology & Toxicology

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Gastroenterology Animal Models

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Data Services

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Drug Discovery

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Tissue Sectioning

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Transmitted Light Microscopy

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Bioanalysis

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