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South Bay Bio

5 Orders Completed
SAN JOSE, California, US

About South Bay Bio

South Bay Bio is a biotechnology company dedicated to providing HTS related products and services with a focus on the ubiquitin proteasome system. The company was formed in the San Francisco Bay area to provide support to local biotechnology companies, and is located in the city of San Jose.

Our mission is to provide innovative & cost effective HTS products & services, accelerating early stage drug development for cancer and neurodegenerative diseases.

The South Bay Bio team consists of accomplished scientists with decades of experience in assay development, HTS, protein purification, and bioconjugation with a history of successful project management. Our advisors include successful scientists and entrepreneurs specialized and focused in commercial HTS, drug discovery, and academic research.

Our Services (8)


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High Throughput Screening (HTS)

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Compound IC50 Assays

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Bioconjugation/Chemical Crosslinking

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We specialize in labeling proteins and antibodies with our Europium and Terbium Cryptates and acceptor fluorophores. We can label proteins site specifically using cysteines or provide you with a FRET-labeled pair of antibodies for your target. We predominantly label monoclonal antibodies using cysteine mutations or amine-reactive crosslinkers. If FRET isn’t what you’re after ask us about our FP assay labeling services or c-terminal derivatives.


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Assay Development

Price on request

Our goal is to help advance you into lead identification and provide you with the tools and knowledge to succeed. We offer a variety of custom biochemistry services with an emphasis on protein production, assay development, and custom protein labeling. Projects are phase-gated and designed for the highest chance of success; and our assay development services are optimal for HTS. All of our assays feature maximal signal to noise, high stability, minimal compound interference, and low solvent quenching effects. We will help you get your project off the ground.


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Protein Purification

Price on request

Our proteins are produced in-house beginning with clones. We use bacterial or insect cell expression for most projects. Proteins are purified using affinity, ion exchange, SEC, or HIC liquid chromatography to attain protein purities of >95%. We can confirm purity by SDS-PAGE or Mass Spectrometry, and QC deliverable product by activity assessment if applicable. Completed proteins can be labeled and further purified to remove excess label. Our enzymes are active and stable.


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Protein Characterization

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Bacterial Protein Expression

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Protein Expression Screening and Optimization

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