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SOLVO Biotechnology, Inc.

5 Orders Completed
Szeged, HU

About SOLVO Biotechnology, Inc.

Type: Privately Held Divison of: Citoxlab Group Affiliates

SOLVO Biotechnology was the first company 19 years ago to start offering transporter protein based products and services commercially and has kept its focus and leading position ever since. Relying on pioneering R&D that resulted in more than 55 peer-reviewed articles, extended service capacity and in-house... Show more »

SOLVO Biotechnology was the first company 19 years ago to start offering transporter protein based products and services commercially and has kept its focus and leading position ever since. Relying on pioneering R&D that resulted in more than 55 peer-reviewed articles, extended service capacity and in-house bioanalytical capabilities, SOLVO has met the expectations of more than 450 customers around the globe, including big pharma and smaller biotech companies. By choosing SOLVO, you gain access to a customized approach that takes into account your drug's characteristics and developmental stage, FDA and EMA expectations, budgetary constraints, project timelines and the vast experience we've gained from the thousands of assays we perform annually.

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Our Services (27)


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Membrane Preparations for Transporter Assays

Price on request
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Drug Transporter Assays

Price on request

Uptake/SLC/Solute carrier transporter assays:
inhibition, IC50, Ki, substrate, Km, Vmax, ASBT, CNT1, CNT2, CNT3, ENT1, ENT2, ENT4, HPT1, NTCP, OAT1, OAT2, OAT3, OATP1A2, OATP1B1, OATP1B3, OATP2A1, OATP2B1, OCT1, OCT2, OCT3, OCTN1, OCTN2, PEPT1, PEPT2, SGLT1, SGLT2, URAT1, rat Ntcp, rat Oat1, rat Oatp1a1, rat Oatp1a4, rat Oatp1b2,... Show more »

Uptake/SLC/Solute carrier transporter assays:
inhibition, IC50, Ki, substrate, Km, Vmax, ASBT, CNT1, CNT2, CNT3, ENT1, ENT2, ENT4, HPT1, NTCP, OAT1, OAT2, OAT3, OATP1A2, OATP1B1, OATP1B3, OATP2A1, OATP2B1, OCT1, OCT2, OCT3, OCTN1, OCTN2, PEPT1, PEPT2, SGLT1, SGLT2, URAT1, rat Ntcp, rat Oat1, rat Oatp1a1, rat Oatp1a4, rat Oatp1b2, rat Octn2, cynomolgous monkey Ntcp, cynomolgous monkey Oatp1b1, cynomolgous monkey Oatp1b3, cynomolgous monkey Oatp2b1, HEK293, CHO, MDCKII

Efflux/ABC/ATP-binding cassette transporter assays:
inhibition, IC50, Ki, substrate, Km, Vmax, P-gp/MDR1, BCRP, BSEP, MRP1, MRP2, MRP3, MRP4, MRP5, MATE1, MATE2K, rat Mdr1a, rat Bcrp, mouse Mdr1a, mouse Bcrp1, rat BSEP, cynomolgous monkey Bcrp, cynomolgous monkey Mdr1, Caco-2, MDCKII, LLC-PK1, HEK293, Sf9

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Human Mouse Rat Rodents Non-human primates (NHP) Endothelial uptake and BBB transport assays Colorimetric vesicle assays bi-directional efflux assays LCMS Radioassay uptake Drug Discovery Toxicology Transporter membrane protein Show 16 more tags Show less

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Multidrug Resistance (MDR) Testing

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, P-gp/MDR1, rat Mdr1a, mouse Mdr1a, cynomolgous monkey Mdr1, Caco-2, MDCKII, LLC-PK1, HEK293, Sf9, rat BBB / blood brain barrier penetration

inhibition, IC50, Ki, substrate, Km, Vmax, P-gp/MDR1, rat Mdr1a, mouse Mdr1a, cynomolgous monkey Mdr1, Caco-2, MDCKII, LLC-PK1, HEK293, Sf9, rat BBB / blood brain barrier penetration

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Human Mouse Rat Rodents Non-human primates (NHP) Endothelial uptake and BBB transport assays substrate assessment inhibition assessment vesicle assays bi-directional efflux assays Primary Cells Brain Drug Discovery Toxicology Transporter membrane protein Show 16 more tags Show less

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Organic Ion Transporter Assays

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, OAT1, OAT2, OAT3, OATP1A2, OATP1B1, OATP1B3, OATP2A1, OATP2B1, OCT1, OCT2, OCT3, OCTN1, OCTN2, rat Oat1, rat Oatp1a1, rat Oatp1a4, rat Oatp1b2, rat Octn2, cynomolgous monkey Oatp1b1, cynomolgous monkey Oatp1b3, cynomolgous monkey Oatp2b1, HEK293, CHO, MDCKII

inhibition, IC50, Ki, substrate, Km, Vmax, OAT1, OAT2, OAT3, OATP1A2, OATP1B1, OATP1B3, OATP2A1, OATP2B1, OCT1, OCT2, OCT3, OCTN1, OCTN2, rat Oat1, rat Oatp1a1, rat Oatp1a4, rat Oatp1b2, rat Octn2, cynomolgous monkey Oatp1b1, cynomolgous monkey Oatp1b3, cynomolgous monkey Oatp2b1, HEK293, CHO, MDCKII

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Human Mouse Rat Rodents Non-human primates (NHP) cellular uptake assays Drug Discovery Toxicology Transporter membrane protein Show 10 more tags Show less

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Nucleoside Transporter Assays

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, CNT1, CNT2, CNT3, ENT1, ENT2, ENT4, HEK293, MDCKII

inhibition, IC50, Ki, substrate, Km, Vmax, CNT1, CNT2, CNT3, ENT1, ENT2, ENT4, HEK293, MDCKII

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Human cellular uptake assays Drug Discovery Toxicology Transporter membrane protein Show 6 more tags Show less

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Peptide Transporter Assays

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, HPT1, PEPT1, PEPT2, CHO, MDCKII

inhibition, IC50, Ki, substrate, Km, Vmax, HPT1, PEPT1, PEPT2, CHO, MDCKII

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Human cellular uptake assays Drug Discovery Toxicology Transporter membrane protein Show 6 more tags Show less

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Glucose Transporter Assays

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, SGLT1, SGLT2, HEK293

inhibition, IC50, Ki, substrate, Km, Vmax, SGLT1, SGLT2, HEK293

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Human cellular uptake assays Drug Discovery Toxicology Transporter membrane protein Show 6 more tags Show less

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Solubility and Dissolution Testing

Price on request

The solubility of the test article in each transporter assay buffer applied in your study will be examined by microscopy.

The solubility of the test article in each transporter assay buffer applied in your study will be examined by microscopy.

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Solubility Studies Physiochemical Tests Small molecules

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Cytotoxicity Assays

Price on request

Acute cytotoxic effect of the test article on cells will be monitored by the resazurin-based cytotoxicity test.
In the standard setup the cells will be incubated with and without test article, at one time point (e.g. the highest incubation time applied in the assay), 1 concentration in triplicates.
Customized setups are available.

Acute cytotoxic effect of the test article on cells will be monitored by the resazurin-based cytotoxicity test.
In the standard setup the cells will be incubated with and without test article, at one time point (e.g. the highest incubation time applied in the assay), 1 concentration in triplicates.
Customized setups are available.

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Human Hamster Pig Dog Cytotoxicity Drug Discovery Toxicology Drug toxicity effect on cells in vitro cultured Show 8 more tags Show less

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Protein Quantification

Price on request

SOLVO Biotechnology is offering Quantification of Transporter Proteins in tissue, cell lines or membrane vesicles by LC/MS-MS.

Transporter quantification by LC/MS-MS allows the quantitative determination of the expression of a particular transporter in the sample of interest. This data will allow more accurate determination of... Show more »

SOLVO Biotechnology is offering Quantification of Transporter Proteins in tissue, cell lines or membrane vesicles by LC/MS-MS.

Transporter quantification by LC/MS-MS allows the quantitative determination of the expression of a particular transporter in the sample of interest. This data will allow more accurate determination of kinetic parameters (e.g. KM, Vmax) and can be used in „in vitro in vivo extrapolations” (IVIVE).

SOLVO offers transporter quantification services as a stand alone service or as an add-on to other in vitro transporter experiments.

Should you be interested in the quantification of a particular transporter

• in the assay system used in our in vitro transporter services,
• in the membrane vesicles you purchase from us,
• or in your in-house samples (Microsomes or plasma membrane fraction, cell lines or cell culture, organs or tissue of interest (liver, kidney, intestine, brain)

List of Transporters

LC/MS-MS Quantification of Transporter Proteins is available for the following set of transporters through our collaborator Bertin Pharma (France).

human BCRP, BSEP, MCT2, MDR1/P-gp, MRP2, NTCP, OCT1, OCT2, OAT1, OAT2, OAT3, OATP1B1, OATP1B3, OATP2B1, PEPT1 & ATPase Na+/K+

mouse Abcb4, Abcc4, Bcrp, Bsep, Mdr1a, Mdr1b, Mrp2, Mrp3, Ntcp, Oatp1a1, Oatp1a4, Abcg8 = sterolin 2, Abcg5 = sterolin 1 & ATPase Na+/K+

Learn more about the LC/MS-MS Quantification of Transporter Protein technology.

Benefits

LC/MS-MS Quantification of Transporter Protein Service has many advantages:

• Available for a wide range of proteins,
• Specific for the selected protein,
• High sensitivity (fmol/ug protein),
• Measurement of activity up to 37 proteins in the same analysis,
• Assays validated according to the state-of-the-art.

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Human Mouse Rodents LCMS Human tissue Drug Discovery Toxicology Transporter membrane protein Show 9 more tags Show less

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Biochemical Assay Kits

Price on request

Ready-to-use efflux or uptake transporter kits
Membrane preparations
Monoclonal antibodies

Ready-to-use efflux or uptake transporter kits
Membrane preparations
Monoclonal antibodies

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Colorimetric Fluorescence vesicle assays bi-directional efflux assays cellular uptake assays Drug Discovery Toxicology Transporter membrane protein Show 9 more tags Show less

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Cell-Based ATP Binding Assays

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, P-gp/MDR1, BCRP, BSEP, MRP1, MRP2, MRP3, MRP4, MRP5, MATE1, MATE2K, rat Mdr1a, rat Bcrp, mouse Mdr1a, mouse Bcrp1, rat BSEP, cynomolgous monkey Bcrp, cynomolgous monkey Mdr1, Caco-2, MDCKII, LLC-PK1, HEK293, Sf9

inhibition, IC50, Ki, substrate, Km, Vmax, P-gp/MDR1, BCRP, BSEP, MRP1, MRP2, MRP3, MRP4, MRP5, MATE1, MATE2K, rat Mdr1a, rat Bcrp, mouse Mdr1a, mouse Bcrp1, rat BSEP, cynomolgous monkey Bcrp, cynomolgous monkey Mdr1, Caco-2, MDCKII, LLC-PK1, HEK293, Sf9

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Human Mouse Rat Rodents Non-human primates (NHP) Cell-based assays substrate assessment inhibition assessment vesicle assays bi-directional efflux assays Drug Discovery Toxicology Transporter membrane protein Show 14 more tags Show less

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Cell Uptake/Transporter Assays

Price on request

inhibition, IC50, Ki, substrate, Km, Vmax, ASBT, CNT1, CNT2, CNT3, ENT1, ENT2, ENT4, HPT1, NTCP, OAT1, OAT2, OAT3, OATP1A2, OATP1B1, OATP1B3, OATP2A1, OATP2B1, OCT1, OCT2, OCT3, OCTN1, OCTN2, PEPT1, PEPT2, SGLT1, SGLT2, URAT1, rat Ntcp, rat Oat1, rat Oatp1a1, rat Oatp1a4, rat Oatp1b2, rat Octn2, cynomolgous monkey Ntcp,... Show more »

inhibition, IC50, Ki, substrate, Km, Vmax, ASBT, CNT1, CNT2, CNT3, ENT1, ENT2, ENT4, HPT1, NTCP, OAT1, OAT2, OAT3, OATP1A2, OATP1B1, OATP1B3, OATP2A1, OATP2B1, OCT1, OCT2, OCT3, OCTN1, OCTN2, PEPT1, PEPT2, SGLT1, SGLT2, URAT1, rat Ntcp, rat Oat1, rat Oatp1a1, rat Oatp1a4, rat Oatp1b2, rat Octn2, cynomolgous monkey Ntcp, cynomolgous monkey Oatp1b1, cynomolgous monkey Oatp1b3, cynomolgous monkey Oatp2b1, HEK293, CHO, MDCKII

FDA/EMA-compliant transporter assays and reports

inhibition, IC50, Ki, substrate, Km, Vmax, P-gp/MDR1, BCRP, BSEP, OATP1B1, OATP1B3, OCT1, OCT2, OAT1, OAT3, MATE1, MATE2K, HEK293, CHO, MDCKII, Sf9

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Human Mouse Rat Rodents Non-human primates (NHP) substrate assessment inhibition assessment cellular uptake assays Drug Discovery Toxicology Transporter membrane protein Show 12 more tags Show less

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Non-Specific Binding Assay

Price on request

Binding of the test article to the plastic ware used in your study will be tested using either liquid scintillation or LC/MS. Binding will be assayed at multiple TA concentrations.

Binding of the test article to the plastic ware used in your study will be tested using either liquid scintillation or LC/MS. Binding will be assayed at multiple TA concentrations.

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Biochemistry & Molecular Biology

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Biology

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Cell-Based Assays

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Toxicology

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Cellular Health & Metabolism Assays

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Chemistry and Materials

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Pharmacology & Toxicology

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Antibody Services

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Biochemical Assays

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Biomolecular Interaction Analysis

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Protein Services

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Analytical Chemistry Services

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Csilla Kegyes

Senior Sales Manager
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Joseph Zolnerciks

VP Business Development

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