SOLVE Research and Consultancy AB
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Lund, SE
SOLVE is a contract analytical lab, located in Sweden and the US, operating highly specialized instrumentation to help you gain knowledge about your materials.
We are a qualified team of PhD level scientists, providing the best analytical capabilities in our quality controlled lab. Our expertise lies in the characterization of materials at the nano- and microscale. We have, for example, helped to improve the yield of recombinant proteins; assess peptide and protein aggregation in therapeutics; develop product platforms based on naturally sourced polymers; improve production and processing by characterization of nanoparticles.
One of our core technologies – field-flow fractionation, AF4, FFF – is a recommended method for small nanoparticles up to large polymers and it can be applied standalone or orthogonal to our other techniques. The method is listed as a preferred method for investigating/validating protein aggregation by the US food and drug administration (FDA), emphasizing the push for more comprehensive characterization strategies.
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We offer label-free comprehensive characterization of biologics including peptides, antibodies, viruses etc and aggregates thereof in complex matrices such as serum/plasma/blood, CSF etc. at the nano- and microscale using Field-Flow Fractionation (FFF, AF4) connected to Multi-Angle Light Scattering (MALS), Refractive Index Detection (RI), UV Detection or Fluorescence Detection combined with label-free detection methods.
We are flexible, and perform everything from smaller feasibility studies for 1-2 samples to larger method developments with a focus towards future routine sample analysis. We have experience working with the following materials:
We offer comprehensive characterization of materials at the nano- and microscale using Size-Exclusion Chromatography (SEC) connected to Multi-Angle Light Scattering (MALS), Refractive Index Detection (RI) and/or UV Detection.
We are flexible, and perform everything from smaller feasibility studies for 1-2 samples to larger method developments with a focus towards future routine sample analysis. We have experience working with the following materials:
The analytical centrifugation instrument with UV absorbance optics allows size analysis of components at close to undisturbed conditions, i.e. with minimal influence from dilution or shear.
We can offer enhanced separation and characterization of complex charged molecules, using the newly developed electrical FFF (EAF4), invaluable for exosomes, drug delivery vehicles, colloidal stability of proteins etc.
The system combines electrical and flow fractionation in a single separation. This is the most versatile separation technology available, with the benefits that analytes with the same size but different charge can be separated and characterized as well as that true size and zeta potential distributions can be determined.
We offer characterization of materials at the nano- and microscale using Dynamic Light Scattering (DLS).
We are flexible, and perform everything from smaller feasibility studies for 1-2 samples to larger method developments with a focus towards future routine sample analysis.
- Instrumentation: Mastersizer Malvern
- Scanning electron microscopy
- Transmission electron microscopy
We offer comprehensive characterization of particles/powders (1 µm to 30 mm) with image analysis using QICPIC.
- Instrumentation: Sympatec QICPIC.
- Application: Particle size and shape analysis, aspect ratio, particle gallery.
- Standard sample requirements: Particles 1 µm to 30 mm.
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