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SOLVE Research and Consultancy AB

Lund, SE

SOLVE is a contract analytical lab, located in Sweden and the US, operating highly specialized instrumentation to help you gain knowledge about your materials. We are a qualified team of PhD level scientists and we provide the best analytical capabilities in our quality controlled lab as well as customized consultation services.

Our expertise lies in the characterization of materials at the nano- and microscale. We address a wide range of materials challenges and have, for example, helped to improve the yield of recombinant proteins; assess peptide and protein aggregation in therapeutics; develop product platforms based on naturally sourced polymers; improve production and processing by characterization of nanoparticles. We contribute to projects from idea to implementation.

One of our core technologies – field-flow fractionation, AF4, FFF – is a recommended method for small nanoparticles up to large polymers as... Show more »

SOLVE is a contract analytical lab, located in Sweden and the US, operating highly specialized instrumentation to help you gain knowledge about your materials. We are a qualified team of PhD level scientists and we provide the best analytical capabilities in our quality controlled lab as well as customized consultation services.

Our expertise lies in the characterization of materials at the nano- and microscale. We address a wide range of materials challenges and have, for example, helped to improve the yield of recombinant proteins; assess peptide and protein aggregation in therapeutics; develop product platforms based on naturally sourced polymers; improve production and processing by characterization of nanoparticles. We contribute to projects from idea to implementation.

One of our core technologies – field-flow fractionation, AF4, FFF – is a recommended method for small nanoparticles up to large polymers as well as fragile protein aggregates, and can be applied standalone or orthogonal to our other techniques. Field-flow fractionation is listed as a preferred method for investigating/validating protein aggregation by the US food and drug administration (FDA) emphasizing the push for more comprehensive characterization strategies.

Recent Publications
- Leeman, M., Choi, J., Hansson, S., Ulmius Storm, M., Nilsson, L. Proteins and antibodies in serum, plasma, and whole blood – size characterization using asymmetrical flow field-flow fractionation (AF4), Anal Bioanal Chem (2018). https://doi.org/10.1007/s00216-018-1127-2
- Bender P, Bogart LK, Posth O, Szczerba W, Rogers SE, Castro A, Nilsson L, Zeng LJ, Sugunan A, Sommertune J, Fornara A, González-Alonso D, Barquín LF, Johansson C. Structural and magnetic properties of multi-core nanoparticles analysed using a generalised numerical inversion method. Sci Rep. 2017 Apr 11;7:45990.
- Leeman, M.; Ulmius Storm, M.; Nilsson, L. Practical Applications of Asymmetrical Flow Field-Flow Fractionation (AF4): A Review, 2015, LCGC Europe. 28 (12).
- Runyon, J.R.; Nilsson, L.; Ulmius, M.; Castro, A.; Ionescu, R.; Andersson, C.; Schmidt, C. Assessing levan solution stability using asymmetric flow field-flow fractionation. Analytical and Bioanalytical Chemistry, 2014, 406, 1597 – 1605.
- Runyon, J.R.; Ulmius, M.; Nilsson, L., A perspective on the characterization of colloids and macromolecules using asymmetrical flow field-flow fractionation, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014, 442, 25 – 33.
- Nilsson L. Separation and characterization of food macromolecules using field-flow fractionation: A review. Food Hydrocolloids, 2013;30:1-11.

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FFF-MALS
Field-flow fractionation with multi-angle light scattering
Price on request

We offer comprehensive characterization of materials at the nano- and microscale using Field-Flow Fractionation (FFF, AF4) connected to Multi-Angle Light Scattering (MALS), Refractive Index Detection (RI), UV Detection or Fluorescence Detection.

  • Instrumentation: Field-Flow Fractionation connected to Multi-Angle Light... Show more »

We offer comprehensive characterization of materials at the nano- and microscale using Field-Flow Fractionation (FFF, AF4) connected to Multi-Angle Light Scattering (MALS), Refractive Index Detection (RI), UV Detection or Fluorescence Detection.

  • Instrumentation: Field-Flow Fractionation connected to Multi-Angle Light Scattering etc.
  • Application: Molar mass and size distribution determination, aggregation, shape, sample recovery
  • Standard sample requirements: Dispersed sample, minimum 100 ug sample
  • Approximate turnaround time: From 5 days upon sample receipt

We are flexible, and perform everything from smaller feasibility studies for 1-2 samples to larger method developments with a focus towards future routine sample analysis. We have experience working with the following materials:

  • Proteins, protein aggregates, protein fragments
  • Peptides and polypeptides
  • Lipoproteins
  • Nanoparticles and microparticles
  • Starches and modified starches
  • Cellulose derivatives
  • β-Glucans, Levans, Gum arabic, Hyaluronan
  • Emulsions
  • Lipid vesicles
  • Synthetic polymers
  • Polyelectrolytes
  • Natural and engineered colloids
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Wyatt
Agilent
Chemstation Astra
Field-Flow Fractionation
Asymmetrical Flow Field-Flow Fractionation
AF4
FFF
Field-flow fractionation
MALS
SEC-MALS
Size exclusion chromatography with multiangle light scattering detectors
Price on request

We offer comprehensive characterization of materials at the nano- and microscale using Size-Exclusion Chromatography (SEC) connected to Multi-Angle Light Scattering (MALS), Refractive Index Detection (RI) and/or UV Detection.

  • Instrumentation: Size-Exclusion Chromatography connected to Multi-Angle Light Scattering etc.
    -... Show more »

We offer comprehensive characterization of materials at the nano- and microscale using Size-Exclusion Chromatography (SEC) connected to Multi-Angle Light Scattering (MALS), Refractive Index Detection (RI) and/or UV Detection.

  • Instrumentation: Size-Exclusion Chromatography connected to Multi-Angle Light Scattering etc.
  • Application: Molar mass and size distribution determination
  • Standard sample requirements: Dispersed sample, minimum 100 ug sample
  • Approximate turnaround time: From 5 days upon sample receipt

We are flexible, and perform everything from smaller feasibility studies for 1-2 samples to larger method developments with a focus towards future routine sample analysis. We have experience working with the following materials:

  • Proteins, protein aggregates, protein fragments
  • Peptides and polypeptides
  • Lipoproteins
  • Nanoparticles and microparticles
  • Starches and modified starches
  • Cellulose derivatives
  • β-Glucans, Levans, Gum arabic, Hyaluronan
  • Emulsions
  • Lipid vesicles
  • Synthetic polymers
  • Polyelectrolytes
  • Natural and engineered colloids
« Show less
Wyatt
Agilent
Chemstation Astra
SEC
Size-exclusion chromatography
HPLC
HPLC-SEC
MALS
SEC-MALS
Dynamic Light Scattering
Price on request

We offer characterization of materials at the nano- and microscale using Dynamic Light Scattering (DLS).

  • Instrumentation: Dynamic Light Scattering, low volume (microwell disposable plates)
  • Application: Molar mass and size distribution determination without fractionation
  • Standard sample requirements: Few microliters of... Show more »

We offer characterization of materials at the nano- and microscale using Dynamic Light Scattering (DLS).

  • Instrumentation: Dynamic Light Scattering, low volume (microwell disposable plates)
  • Application: Molar mass and size distribution determination without fractionation
  • Standard sample requirements: Few microliters of sample
  • Approximate turnaround time: From 5 days upon sample receipt

We are flexible, and perform everything from smaller feasibility studies for 1-2 samples to larger method developments with a focus towards future routine sample analysis.

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Wyatt
Zetasizer Nano ZS
Malvern
DLS
DLS (Dynamic Light Scattering)
Dynapro Plate Reader
Zeta-potential
Image Analysis
Price on request

We offer comprehensive characterization of particles/powders (1 µm to 30 mm) with image analysis using QICPIC.

  • Instrumentation: Sympatec QICPIC
  • Application: Particle size and shape analysis, fiber evaluation, particle gallery
  • Standard sample requirements: Particles 1 µm to 30 mm
  • Approximate turnaround time: From 5 days upon sample receipt

We offer comprehensive characterization of particles/powders (1 µm to 30 mm) with image analysis using QICPIC.

  • Instrumentation: Sympatec QICPIC
  • Application: Particle size and shape analysis, fiber evaluation, particle gallery
  • Standard sample requirements: Particles 1 µm to 30 mm
  • Approximate turnaround time: From 5 days upon sample receipt
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Sympatec QICPIC
WINDOX
Size Exclusion Chromatography (SEC)
Price on request

We offer comprehensive characterization of materials at the nano- and microscale using Size-Exclusion Chromatography (SEC) connected to Multi-Angle Light Scattering (MALS), Refractive Index Detection (RI) and/or UV Detection.

  • Instrumentation: Size-Exclusion Chromatography connected to Multi-Angle Light Scattering etc.
    -... Show more »

We offer comprehensive characterization of materials at the nano- and microscale using Size-Exclusion Chromatography (SEC) connected to Multi-Angle Light Scattering (MALS), Refractive Index Detection (RI) and/or UV Detection.

  • Instrumentation: Size-Exclusion Chromatography connected to Multi-Angle Light Scattering etc.
  • Application: Molar mass and size distribution determination
  • Standard sample requirements: Dispersed sample, minimum 100 ug sample
  • Approximate turnaround time: From 5 days upon sample receipt

We are flexible, and perform everything from smaller feasibility studies for 1-2 samples to larger method developments with a focus towards future routine sample analysis. We have experience working with the following materials:

  • Proteins, protein aggregates, protein fragments
  • Peptides and polypeptides
  • Lipoproteins
  • Nanoparticles and microparticles
  • Starches and modified starches
  • Cellulose derivatives
  • β-Glucans, Levans, Gum arabic, Hyaluronan
  • Emulsions
  • Lipid vesicles
  • Synthetic polymers
  • Polyelectrolytes
  • Natural and engineered colloids
« Show less
Wyatt
Agilent
Chemstation Astra
Analytical Ultracentrifugation (AUC)
Price on request

The analytical centrifugation instrument with UV absorbance optics allows size analysis of components at close to undisturbed conditions, i.e. with minimal influence from dilution or shear.

The analytical centrifugation instrument with UV absorbance optics allows size analysis of components at close to undisturbed conditions, i.e. with minimal influence from dilution or shear.

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Analytical Ultracentrifugation
Analytical Chemistry Services
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Chromatography
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Scattering Techniques
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Computational Modeling
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Spectroscopy
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Purification Services
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Liquid Chromatography Coupled Mass Spectrometry Methods
Price on request

Liquid Chromatography Coupled Mass Spectrometry Methods Services

Liquid Chromatography Coupled Mass Spectrometry Methods Services

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LC-MS
Liquid Chromatography-Coupled Mass Spectrometry
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Lipoprotein Analysis
Price on request
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Chemistry and Materials
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Data Services
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Imaging & Spectroscopy
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Centrifugation
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Centrifugation Services

Centrifugation Services

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Mass Spectrometry
Price on request

Mass Spectrometry Services

Mass Spectrometry Services

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Project and Process Management
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Lipid Services
Price on request

Lipid Services

Lipid Services

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Biochemistry & Molecular Biology
Price on request

Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

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Biology
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Biology Services

Biology Services

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2018-08-09 13:01:14 -0400

Net Promoter Score of 9 received for FFF-MALS.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2018-07-05 12:07:46 -0400

Net Promoter Score of 9 received for FFF-MALS.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 10.

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