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SOLVE Research and Consultancy AB

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4 Orders Completed
Lund, SE

About SOLVE Research and Consultancy AB

SOLVE is a contract analytical lab, helping customers all around the world with AF4-MALS, SEC-MALS, AUC and DLS analysis and method development. 

 

Our expertise lies in the characterization of materials at the nano- and microscale. One of our core technologies – field-flow fractionation, AF4, FFF – is listed as a preferred method for investigating/validating protein aggregation by the US food and drug administration (FDA), emphasizing the push for more comprehensive characterization strategies.

 

Recent Publications

  • Leeman, M., Choi, J., Hansson, S., Ulmius Storm, M., Nilsson, L. Proteins and antibodies in serum, plasma, and whole blood – size characterization using asymmetrical flow field-flow fractionation (AF4), Anal Bioanal Chem (2018). https://doi.org/10.1007/s00216-018-1127-2.
  • Bender P, Bogart LK, Posth O, Szczerba W, Rogers SE, Castro A, Nilsson L, Zeng LJ, Sugunan A, Sommertune J, Fornara A, González-Alonso D, Barquín LF, Johansson C. Structural and magnetic properties of multi-core nanoparticles analysed using a generalised numerical inversion method. Sci Rep. 2017 Apr 11;7:45990.
  • Leeman, M.; Ulmius Storm, M.; Nilsson, L. Practical Applications of Asymmetrical Flow Field-Flow Fractionation (AF4): A Review, 2015, LCGC Europe. 28 (12).
  • Runyon, J.R.; Nilsson, L.; Ulmius, M.; Castro, A.; Ionescu, R.; Andersson, C.; Schmidt, C. Assessing levan solution stability using asymmetric flow field-flow fractionation. *Analytical and Bioanalytical Chemistry*, 2014, 406, 1597 – 1605.
  • Runyon, J.R.; Ulmius, M.; Nilsson, L., A perspective on the characterization of colloids and macromolecules using asymmetrical flow field-flow fractionation, *Colloids and Surfaces A: Physicochemical and Engineering Aspects*, 2014, 442, 25 – 33.
  • Nilsson L. Separation and characterization of food macromolecules using field-flow fractionation: A review. *Food Hydrocolloids*, 2013;30:1-11.

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Our Services (11)

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FFF-MALS

Field-flow fractionation with multi-angle light scattering
Price on request

We offer label-free comprehensive characterization of biologics including peptides, antibodies, viruses etc and aggregates thereof in complex matrices such as serum/plasma/blood, CSF etc. at the nano- and microscale using Field-Flow Fractionation (FFF, AF4) connected to Multi-Angle Light Scattering (MALS), Refractive Index Detection (RI), UV Detection or Fluorescence Detection combined with label-free detection methods.

  • Instrumentation: Field-Flow Fractionation connected to Multi-Angle Light Scattering etc.
  • Application: Molar mass and size distribution determination, aggregation, shape, sample recovery
  • Standard sample requirements: Dispersed sample, minimum 100 ug sample
  • Approximate turnaround time: From 5 days upon sample receipt

We are flexible, and perform everything from smaller feasibility studies for 1-2 samples to larger method developments with a focus towards future routine sample analysis. We have experience working with the following materials:

  • Proteins, protein aggregates, protein fragments
  • Peptides and polypeptides
  • Lipoproteins
  • Nanoparticles and microparticles
  • Starches and modified starches
  • Cellulose derivatives
  • β-Glucans, Levans, Gum arabic, Hyaluronan
  • Emulsions
  • Lipid vesicles
  • Synthetic polymers
  • Polyelectrolytes
  • Natural and engineered colloids

Wyatt Chemstation Astra Asymmetrical Flow Field-Flow Fractionation FFF Field-flow fractionation MALS dRI Fluorescence UV Proteins Biopharmaceuticals/Biologics Antibodies Exosomes Biology Drug Discovery Neuroscience Toxicology ADC ADCs Anti-drug Conjugates Anti-peptide Drug Conjugates Aptamers Biotherapeutics Blood Brain Human tissue miRNA Monoclonal antibodies Peptide-Drug Conjugates Peptides PBMC's Plasma polyclonal Antibodies Serum RNA milligram Aging Autoimmunity Cardiovascular CNS/Neurology Fibrotic Disease Hematology Hepatology Immuno-Oncology Immunology Infectious Disease Inflammation Metabolic Disease Metabolism and Endocrinology Neurology Oncology Ophthalmology Pain Pediatrics Rare Disease Rheumatology Virology Wyatt Show 58 more tags Show less
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SEC-MALS

Size exclusion chromatography with multiangle light scattering detectors
Price on request

We offer comprehensive characterization of materials at the nano- and microscale using Size-Exclusion Chromatography (SEC) connected to Multi-Angle Light Scattering (MALS), Refractive Index Detection (RI) and/or UV Detection.

  • Instrumentation: Size-Exclusion Chromatography connected to Multi-Angle Light Scattering etc.
  • Application: Molar mass and size distribution determination
  • Standard sample requirements: Dispersed sample, minimum 100 ug sample
  • Approximate turnaround time: From 5 days upon sample receipt

We are flexible, and perform everything from smaller feasibility studies for 1-2 samples to larger method developments with a focus towards future routine sample analysis. We have experience working with the following materials:

  • Proteins, protein aggregates, protein fragments
  • Peptides and polypeptides
  • Lipoproteins
  • Nanoparticles and microparticles
  • Starches and modified starches
  • Cellulose derivatives
  • β-Glucans, Levans, Gum arabic, Hyaluronan
  • Emulsions
  • Lipid vesicles
  • Synthetic polymers
  • Polyelectrolytes
  • Natural and engineered colloids

Wyatt Chemstation Astra Analytical SEC HPLC-SEC SEC-MALS MALS HPLC Biology Drug Discovery Neuroscience Toxicology Agilent Wyatt Antibodies Biotherapeutics Proteins milligram Show 17 more tags Show less
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Analytical Ultracentrifugation (AUC)

Price on request

The analytical centrifugation instrument with UV absorbance optics allows size analysis of components at close to undisturbed conditions, i.e. with minimal influence from dilution or shear.

Analytical Ultracentrifugation Biology Drug Discovery Neuroscience Toxicology Beckman Optima AUC Proteins Antibodies Protein-Drug Conjugates Show 9 more tags Show less
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Electrical FFF-MALS (EAF4-MALS)

Price on request

We can offer enhanced separation and characterization of complex charged molecules, using the newly developed electrical FFF (EAF4), invaluable for exosomes, drug delivery vehicles, colloidal stability of proteins etc.

The system combines electrical and flow fractionation in a single separation. This is the most versatile separation technology available, with the benefits that analytes with the same size but different charge can be separated and characterized as well as that true size and zeta potential distributions can be determined.

AF4 Pharmacology Environmental Science Field-flow fractionation MALS Wyatt Biopharmaceuticals/Biologics Proteins Exosomes Show 9 more tags Show less
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Dynamic Light Scattering

Price on request

We offer characterization of materials at the nano- and microscale using Dynamic Light Scattering (DLS).

  • Instrumentation: Dynamic Light Scattering, low volume (microwell disposable plates)
  • Application: Molar mass and size distribution determination without fractionation
  • Standard sample requirements: Few microliters of sample
  • Approximate turnaround time: From 5 days upon sample receipt

We are flexible, and perform everything from smaller feasibility studies for 1-2 samples to larger method developments with a focus towards future routine sample analysis.

Wyatt Malvern Dynapro Plate Reader Zetasizer Nano ZS DLS (Dynamic Light Scattering) Zeta-potential Biology Antibiotic Development Toxicology Drug Discovery Proteins Biopharmaceuticals/Biologics nanoparticles Show 13 more tags Show less
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Laser Diffraction Analysis

Price on request

- Instrumentation: Mastersizer Malvern

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Surface Tension Measurement

Price on request
Request a quote for more information about this service.
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Electron Microscopy

Price on request

- Scanning electron microscopy
- Transmission electron microscopy

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Image Analysis

Price on request

We offer comprehensive characterization of particles/powders (1 µm to 30 mm) with image analysis using QICPIC.

- Instrumentation: Sympatec QICPIC.
- Application: Particle size and shape analysis, aspect ratio, particle gallery. 
- Standard sample requirements: Particles 1 µm to 30 mm.

Sympatec QICPIC WINDOX
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Microscopy Image Analysis

Price on request
Request a quote for more information about this service.
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Particle Size Distribution

Price on request
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AC

Alejandra Castro Nilsson

CEO
ML

Mats Leeman

Senior Scientist

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