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Société des systèmes biologiques

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Apprieu, FR

About Société des systèmes biologiques

Expert in immunotechnology since 1980, BIOTEM is a Contract Research Organisation which provides high added value services for the development of custom monoclonal antibodies and immunoassays (ELISA & LFIA).

Complying with ISO 9001:2015 / ISO 13485:2016 Quality Standards, the company has been the privileged partner of more than 400 prestigious industrial and academic laboratories for their projects in fundamental research, development of improved diagnostics or generation of promising therapeutic tools.

Based on a high level of expertise and exclusive technologies, BIOTEM implements the most relevant strategies for each project according to the client’s specifications.

As a benefit, BIOTEM is keen to propose contracts with guaranteed results.

From the generation of original monoclonal antibodies ̶ by hybridoma and Phage Display technologies ̶ through their production, characterisation (affinity & specificity determination, sequencing, stability studies,…) and immunoassay developments, BIOTEM offers a wide range of customised services.

Besides, BIOTEM is strongly involved in different R&D programmes implemented either internally or in collaboration. These programmes aim to:

  • Optimise existing processes and develop new approaches for monoclonal antibody generations
  • Develop new monoclonal antibodies against relevant targets for diagnostic and therapeutic purposes
  • Propose innovative technologies to build new screening tools (rapid tests, biosensors, etc.)

Our Services (11)


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Chimeric Antibody Production

Price on request

Chimeric antibodies are antibodies combining parental antibody variable regions with any acceptor constant region. Thanks to the domain organization of antibodies, chimerization is straightforward and does not alter antibody affinity or specificity. The combination of rodent variable domains with human constant domains is the most widespread, however, we can combine your variable domains with constant domains of diverse species.

Applications:

  • Therapeutic: Antibody chimerization is a preliminary step before antibody humanization in order to associate biological function to parental antibody and to decrease its immunogenicity. Alternatively, chimeric antibodies can be employed for therapeutic purposes in particular diseases (e.g. for immunocompromised patients) or under certain conditions (variable domain with high GI).
  • Diagnostic: Chimeric antibodies are the best alternative to serum, calibrators and positive controls in diagnostics assays. They are particularly suitable as they can be produced in unlimited quantities and homogeneous (preservation of antibody specificity and affinity.

BIOTEM chimerization platform combines parental variable domains to any constant domain (IgG1, IgG4, IgM etc.).


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Antibody Development

Price on request

Development and production of humanized antibody

Key Advantages:

  • Modernized CDR-grafting using human germline sequences
  • Preserved parental affinity and specificity
  • Improved antibody drugability and manufacturability
  • Starting from your parental antibody or from scratch

100 % fee-for-service: no claims, no royalties, no follow-up rights.

Humanization by CDR-grafting consists in transferring parental (commonly rodent) complementarity determining regions (CDR) into human framework (FR) regions. Parental antibody specificity and affinity are conserved thanks to the preservation of residues implicated in antigen binding. This technology aims at reducing antibody immunogenicity in humans by eliminating xenogeneic residues not involved in antigen recognition.

Humanized antibodies constitute the majority of today’s approved therapeutic antibodies.

BIOTEM’s strategy uses human germline sequences as they form the true immunological self. By using them, instead of mature human immunoglobulin sequences, antibody tolerance in humans is reinforced.


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Polyclonal Antibody Development

Price on request

Developing polyclonal antibodies is a convenient and versatile approach for the detection of target antigens.

Obtaining a quality polyclonal serum that meets all specifications (application, specificity, cross-reaction, etc.) requires the implementation of a specific protocol.


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Monoclonal Antibody (mAb) Production

Price on request

BIOTEM ‘s expertise and know-how are internationally recognised. The efficient generation of monoclonal antibodies requires to strategically master two crucial stages:

Immunisation / Fusion

The company masters a wide range of technologies which allows the achievement of highly challenging projects.

Screening

For each project, our team carries out the most relevant screening strategy to identify the desired hybridomas / antibodies (with reduced risks of generating false positive and false negative results).


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Antibody Purification

Price on request
Request a quote for more information about this service.

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Peptide Synthesis

Price on request
  • 70 to 99 % purity
  • From 1mg to >1g
  • Modification available : Phosphorylation, Nitration, Cyclisation...


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Monoclonal Antibody (mAb) Production

Price on request

BIOTEM ‘s expertise and know-how are internationally recognised. The efficient generation of monoclonal antibodies requires to strategically master two crucial stages:

Immunisation / Fusion

The company masters a wide range of technologies which allows the achievement of highly challenging projects.

Screening

For each project, our team carries out the most relevant screening strategy to identify the desired hybridomas / antibodies (with reduced risks of generating false positive and false negative results).


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Feasibility Studies

Price on request
Request a quote for more information about this service.

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ELISA

Enzyme-linked immunosorbent assay
Price on request

Principally used for R&D and for in vitro diagnostic, ELISA tests are enzymatic immunoassays for the detection and quantification of analytes in equipped laboratories:

  • Simultaneous measurement of a large number of samples
  • Duration : 30 minutes to several hours
  • Quantitative results
  • Optimal limit of detection
  • Reliable and robust


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Immunoassay Development

Price on request

BIOTEM offers cutting edge services for the development of custom ELISA and Lateral Flow ImmunoAssay (LFIA) for the detection and quantification of analytes.

With more than 30 years of experience and a strong expertise, BIOTEM proposes contracts with guaranteed results for the development and validation of your test.


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Lateral Flow Assay

Price on request

Lateral Flow tests (immunochromatography system assays) are based on the migration of nano or micro particles on strips for analytes detection in several areas:

  • Human and animal diagnostics Point of Care testing (PoC)
  • Industrial QC
  • Forensics, biowarfare, etc.
  • Environmental testing
    • Rapid test (<15 minutes)
    • Reliable and easy-to-use (no special equipment required nor trained staff)
    • Semi-quantitative or quantitative results
    • Non-refrigerated storage
    • Economical industrial production


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Clarence Deffaud

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