2 Orders Completed
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SMALTIS

Besancon, FR

SMALTIS is a biotechnology company, specialised in the fields of bacteriology and molecular biology. Created by two young doctors in Bacteriology: Sophie Guénard and Cédric Muller, its mission is assisting public and private research laboratories in carrying out their projects. Various individualised services in bacteriology and molecular biology are available, from producing inactivation mutants to determining the levels of resistance to all types of drugs through the construction of vectors or production of plasmids.

To ensure the highest level of quality for its customers, the laboratory is enrolled in an ISO 9001 certification programme.

Our watchwords are rigour, efficiency, responsiveness and flexibility, IN COMPLETE CONFIDENTIALITY.

Publications

  • Guénard, S., Muller, C., Monlezun, L., Benas, P., Broutin, I., Jeannot, K., and Plesiat, P. (2013) Multiple mutations lead to MexXY/OprM-dependent... Show more »

SMALTIS is a biotechnology company, specialised in the fields of bacteriology and molecular biology. Created by two young doctors in Bacteriology: Sophie Guénard and Cédric Muller, its mission is assisting public and private research laboratories in carrying out their projects. Various individualised services in bacteriology and molecular biology are available, from producing inactivation mutants to determining the levels of resistance to all types of drugs through the construction of vectors or production of plasmids.

To ensure the highest level of quality for its customers, the laboratory is enrolled in an ISO 9001 certification programme.

Our watchwords are rigour, efficiency, responsiveness and flexibility, IN COMPLETE CONFIDENTIALITY.

Publications

  • Guénard, S., Muller, C., Monlezun, L., Benas, P., Broutin, I., Jeannot, K., and Plesiat, P. (2013) Multiple mutations lead to MexXY/OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa. Antimicrob Agents Chemother.
  • Buyck, J. M., Guénard, S., Plesiat, P., Tulkens, P. M., and Van Bambeke, F. (2012). Role of MexAB-OprM in intrinsic resistance of Pseudomonas aeruginosa to temocillin and impact on the susceptibility of strains isolated from patients suffering from cystic fibrosis. J Antimicrob Chemother 67, 771-5.
  • Muller, C., Plesiat, P., and Jeannot, K. (2011). A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa. Antimicrob Agents Chemother 55, 1211-21.
  • Vettoretti, L., Plesiat, P., Muller, C., El Garch, F., Phan, G., Attree, I., Ducruix, A., and Llanes, C. (2009). Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrob Agents Chemother 53, 1987-97.

Awards

  • July 2013: Winner of the 15th national competition for assistance in the creation of innovative technology companies, organised by the Ministry of Higher Education and Research in partnership with Bpifrance funding.
  • 2012: Winner of the "Entrepreneuriales 2012" competition.
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Knock-out Bacteria
Price on request

Gene inactivation by homologous recombination (creation of knockout bacteria)

Through gene inactivation by a homologous recombination technique leading to the total deletion of the gene (near to the base) without leaving any additional DNA sequences (antibiotic resistance cassettes), SMALTIS can construct for you the deletion... Show more »

Gene inactivation by homologous recombination (creation of knockout bacteria)

Through gene inactivation by a homologous recombination technique leading to the total deletion of the gene (near to the base) without leaving any additional DNA sequences (antibiotic resistance cassettes), SMALTIS can construct for you the deletion mutants (knockout) you need for Pseudomonas aeruginosa, P. fluorescens, Klebsiella pneumoniae or other bacteria. Thanks to this capability, you can obtain KO mutants derived from your own bacterial strains.

We can also complement chromosomally the various genetic targets in your bacterial strains.

Applications which can be considered:

  • Identification of the function of a protein
  • Study of control pathways
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Rotor-Gene 6000
Microbial Identification and Strain Typing
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SMALTIS can identify and quantify the different bacterial species which may be present in a sample or on a surface.

Services offered:

  • identification and quantification of bacteria in the sample by culture: enables in particular the identification of pathogenic species.
  • identification and quantification of bacteria in... Show more »

SMALTIS can identify and quantify the different bacterial species which may be present in a sample or on a surface.

Services offered:

  • identification and quantification of bacteria in the sample by culture: enables in particular the identification of pathogenic species.
  • identification and quantification of bacteria in the sample by PCR (quantitative or RT-qPCR): a precise measurement for estimating the bacterial load and the identification of specific species.
  • quantification by luminescence (identification of bacteria, moulds and yeasts).

Applications which can be considered:

  • Studies relating to the hygiene of public or private places: we can define the state of cleanliness of a public or private place by measuring the degree of contamination of various control points.
  • Verification of the sterility of various products, whether cosmetic or food.
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Rotor-Gene 6000
Antimicrobial Activity Testing
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Determination of resistance to different drugs

We can perform in vitro determination of the sensitivity of your bacterial strains to various drugs, such as antibiotics, antiseptics, dyes, etc.

SMALTIS can also identify the associated resistance mechanisms, as well as their genetic origin.

*Panel of methods... Show more »

Determination of resistance to different drugs

We can perform in vitro determination of the sensitivity of your bacterial strains to various drugs, such as antibiotics, antiseptics, dyes, etc.

SMALTIS can also identify the associated resistance mechanisms, as well as their genetic origin.

Panel of methods available:

  • Antibiotic susceptibility testing by agar diffusion method, as recommended by the CA-SFM (Comité de l'Antibiogramme de la Société Française de Microbiologie [Antibiogram Committee of the French Society for Microbiology]).
  • Determination of the MIC (Minimum Inhibitory Concentrations)
    • agar diffusion technique
    • macrodilution method in liquid medium
    • test strips (Etest)
    • microplates (Sensititre)
  • Performing bactericidal curves.
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Rotor-Gene 6000
Mycoplasma Testing
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Detect mycoplasmas in culture supernatants.

Detect mycoplasmas in culture supernatants.

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Rotor-Gene 6000
Vector Construction and Optimization
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Rotor-Gene 6000
DNA Purification
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Rotor-Gene 6000
Plasmid DNA Preparation
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Rotor-Gene 6000
Metatranscriptomics
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Rotor-Gene 6000
Metagenomics
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Rotor-Gene 6000
RNA Sequencing
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Rotor-Gene 6000
Whole Genome Sequencing
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SMALTIS has developed a partnership with a company specialized in the next generation sequencing technologies which allows us to perform whole bacterial genome sequencing.

SMALTIS has developed a partnership with a company specialized in the next generation sequencing technologies which allows us to perform whole bacterial genome sequencing.

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Rotor-Gene 6000
MALDI TOF MS
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
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Rotor-Gene 6000
16S rRNA Sequencing
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Rotor-Gene 6000
Site-Directed Mutagenesis
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We can perform chromosomal directed mutagenesis to modify directly one or more nucleotides of a chromosomal sequence.

We can perform chromosomal directed mutagenesis to modify directly one or more nucleotides of a chromosomal sequence.

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Rotor-Gene 6000
qPCR
Quantitative PCR
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Rotor-Gene 6000
Antimicrobial Susceptibility Testing
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As recommended by CLSI and CA-SFM.

As recommended by CLSI and CA-SFM.

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Rotor-Gene 6000
PCR
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Rotor-Gene 6000
Minimum Inhibitory Concentration (MIC) Assay
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Rotor-Gene 6000
Phage Plaque Assay
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Rotor-Gene 6000
Fractional Inhibitory Concentration (FIC) Index Measurement
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Rotor-Gene 6000
Antibiotic Kill Curve Assay
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Rotor-Gene 6000
Microbiology Assays
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Clinical Laboratory Services
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Viral Production and Assays
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Imaging & Spectroscopy
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RNA
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Biochemistry & Molecular Biology
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Next Generation Sequencing (NGS)
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MALDI Mass Spectrometry Methods
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Nucleic Acid Services
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Pharmacology & Toxicology
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DNA
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Testing of Cell Lines
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Clinical Microbiology, Virology and Parasitology
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Mutagenesis
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DNA Sequencing
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Bacterial Culture
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Biology
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Spectroscopy
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DNA Extraction and Purification
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Viral Assays
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Plasmids and Vectors
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Microbiology, Virology, and Parasitology
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Mass Spectrometry
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Cells and Tissues
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Clinical Research
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2018-05-02 06:14:55 -0500

Net Promoter Score of 10 received for PCR.

Additional Ratings: satisfaction with timeliness: 10.
March 28, 2018

Positive review received for PCR:

"It was my pleasure working with SMALTIS, the report was well written and delivered on time, i highly recommend this lab."

2018-03-24 06:30:06 -0500

Net Promoter Score of 10 received for PCR.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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