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SMALTIS

ic 10.0/10 Overall Rating 100% Positive
ic 3 Orders Completed
Besancon, FR

About SMALTIS

SMALTIS is a biotechnology company, specialised in the fields of bacteriology and molecular biology. Created by two young doctors in Bacteriology: Sophie Guénard and Cédric Muller, its mission is assisting public and private research laboratories in carrying out their projects. Various individualised services... Show more »

SMALTIS is a biotechnology company, specialised in the fields of bacteriology and molecular biology. Created by two young doctors in Bacteriology: Sophie Guénard and Cédric Muller, its mission is assisting public and private research laboratories in carrying out their projects. Various individualised services in bacteriology and molecular biology are available, from producing inactivation mutants to determining the levels of resistance to all types of drugs through the construction of vectors or production of plasmids.

To ensure the highest level of quality for its customers, the laboratory is enrolled in an ISO 9001 certification programme.

Our watchwords are rigour, efficiency, responsiveness and flexibility, IN COMPLETE CONFIDENTIALITY.

Publications

  • Guénard, S., Muller, C., Monlezun, L., Benas, P., Broutin, I., Jeannot, K., and Plesiat, P. (2013) Multiple mutations lead to MexXY/OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa. Antimicrob Agents Chemother.
  • Buyck, J. M., Guénard, S., Plesiat, P., Tulkens, P. M., and Van Bambeke, F. (2012). Role of MexAB-OprM in intrinsic resistance of Pseudomonas aeruginosa to temocillin and impact on the susceptibility of strains isolated from patients suffering from cystic fibrosis. J Antimicrob Chemother 67, 771-5.
  • Muller, C., Plesiat, P., and Jeannot, K. (2011). A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa. Antimicrob Agents Chemother 55, 1211-21.
  • Vettoretti, L., Plesiat, P., Muller, C., El Garch, F., Phan, G., Attree, I., Ducruix, A., and Llanes, C. (2009). Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrob Agents Chemother 53, 1987-97.

Awards

  • July 2013: Winner of the 15th national competition for assistance in the creation of innovative technology companies, organised by the Ministry of Higher Education and Research in partnership with Bpifrance funding.
  • 2012: Winner of the "Entrepreneuriales 2012" competition.
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Our Services (46)


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Knockout Bacteria

Price on request

Gene inactivation by homologous recombination (creation of knockout bacteria)

Through gene inactivation by a homologous recombination technique leading to the total deletion of the gene (near to the base) without leaving any additional DNA sequences (antibiotic resistance cassettes), SMALTIS can construct for you the deletion... Show more »

Gene inactivation by homologous recombination (creation of knockout bacteria)

Through gene inactivation by a homologous recombination technique leading to the total deletion of the gene (near to the base) without leaving any additional DNA sequences (antibiotic resistance cassettes), SMALTIS can construct for you the deletion mutants (knockout) you need for Pseudomonas aeruginosa, P. fluorescens, Klebsiella pneumoniae or other bacteria. Thanks to this capability, you can obtain KO mutants derived from your own bacterial strains.

We can also complement chromosomally the various genetic targets in your bacterial strains.

Applications which can be considered:

  • Identification of the function of a protein
  • Study of control pathways
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Rotor-Gene 6000

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Microbial Identification and Strain Typing

Price on request

SMALTIS can identify and quantify the different bacterial species which may be present in a sample or on a surface.

Services offered:

  • identification and quantification of bacteria in the sample by culture: enables in particular the identification of pathogenic species.
  • identification and quantification of bacteria in... Show more »

SMALTIS can identify and quantify the different bacterial species which may be present in a sample or on a surface.

Services offered:

  • identification and quantification of bacteria in the sample by culture: enables in particular the identification of pathogenic species.
  • identification and quantification of bacteria in the sample by PCR (quantitative or RT-qPCR): a precise measurement for estimating the bacterial load and the identification of specific species.
  • quantification by luminescence (identification of bacteria, moulds and yeasts).

Applications which can be considered:

  • Studies relating to the hygiene of public or private places: we can define the state of cleanliness of a public or private place by measuring the degree of contamination of various control points.
  • Verification of the sterility of various products, whether cosmetic or food.
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Rotor-Gene 6000

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Antimicrobial Activity Testing

Price on request

Determination of resistance to different drugs

We can perform in vitro determination of the sensitivity of your bacterial strains to various drugs, such as antibiotics, antiseptics, dyes, etc.

SMALTIS can also identify the associated resistance mechanisms, as well as their genetic origin.

*Panel of methods... Show more »

Determination of resistance to different drugs

We can perform in vitro determination of the sensitivity of your bacterial strains to various drugs, such as antibiotics, antiseptics, dyes, etc.

SMALTIS can also identify the associated resistance mechanisms, as well as their genetic origin.

Panel of methods available:

  • Antibiotic susceptibility testing by agar diffusion method, as recommended by the CA-SFM (Comité de l'Antibiogramme de la Société Française de Microbiologie [Antibiogram Committee of the French Society for Microbiology]).
  • Determination of the MIC (Minimum Inhibitory Concentrations)
    • agar diffusion technique
    • macrodilution method in liquid medium
    • test strips (Etest)
    • microplates (Sensititre)
  • Performing bactericidal curves.
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Rotor-Gene 6000

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Mycoplasma Testing

Price on request

Detect mycoplasmas in culture supernatants.

Detect mycoplasmas in culture supernatants.

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Rotor-Gene 6000

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Vector Construction and Optimization

Price on request
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Rotor-Gene 6000

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DNA Purification

Price on request
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Rotor-Gene 6000

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Plasmid DNA Preparation

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Rotor-Gene 6000

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Metatranscriptomics

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Rotor-Gene 6000

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Metagenomics

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Rotor-Gene 6000

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RNA Sequencing

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Rotor-Gene 6000

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Whole Genome Sequencing

Price on request

SMALTIS has developed a partnership with a company specialized in the next generation sequencing technologies which allows us to perform whole bacterial genome sequencing.

SMALTIS has developed a partnership with a company specialized in the next generation sequencing technologies which allows us to perform whole bacterial genome sequencing.

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Rotor-Gene 6000

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MALDI TOF MS

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
Price on request
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Rotor-Gene 6000

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16S rRNA Sequencing

Price on request
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Rotor-Gene 6000

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Site-Directed Mutagenesis

Price on request

We can perform chromosomal directed mutagenesis to modify directly one or more nucleotides of a chromosomal sequence.

We can perform chromosomal directed mutagenesis to modify directly one or more nucleotides of a chromosomal sequence.

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Rotor-Gene 6000

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qPCR

Quantitative PCR
Price on request
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Rotor-Gene 6000

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Antimicrobial Susceptibility Testing

Price on request

As recommended by CLSI and CA-SFM.

As recommended by CLSI and CA-SFM.

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Rotor-Gene 6000

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PCR

Price on request
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Rotor-Gene 6000

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Minimum Inhibitory Concentration (MIC) Assay

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Rotor-Gene 6000

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Viral Load Determination

Price on request
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Rotor-Gene 6000

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Fractional Inhibitory Concentration (FIC) Index Measurement

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Rotor-Gene 6000

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Antibiotic Kill Curve Assay

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Rotor-Gene 6000

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Microbiology Assays

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Clinical Laboratory Services

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Virology Services

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Imaging & Spectroscopy

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RNA Services

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Biochemistry & Molecular Biology

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Next Generation Sequencing (NGS)

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MALDI Mass Spectrometry Methods

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Nucleic Acid Services

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Pharmacology & Toxicology

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DNA Services

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Testing of Cell Lines

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Clinical Microbiology, Virology and Parasitology

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Mutagenesis

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DNA Sequencing

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Bacterial Culture

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Biology

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Spectroscopy

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DNA Extraction and Purification

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Viral Assays

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Plasmids and Vectors

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Microbiology

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Mass Spectrometry

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Cells and Tissues

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Clinical Research

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Cédric Muller

Co-founder and CEO
  • Positive review for PCR:

    March 2018

    "It was my pleasure working with SMALTIS, the report was well written and delivered on time, i highly recommend this lab."

SMALTIS has not received any endorsements.