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Small Molecule Screening Core Facility

Buffalo, New York, US

The Small Molecule Screening Core Facility (SMSC) at Roswell Park Cancer Institute offers high-throughput screening services using a broad range of non-radioactive cell based and biochemical assays at a competitive price. Our collection of more than 110,000 compounds can be used in both 96- and 384-well format. Liquid handling and library delivery equipment allows a throughput rate of up to 16,000 data points per day.

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Cell-Based Compound Screening
Price on request

Screening of the library of your choice, and database formation

Typical screening of drug discovery libraries (105,000 drug-like molecules) takes 4-5 weeks depending on the assay type.
Three libraries of known bioactive compounds can be screened in one day at very affordable price*:
LOPAC, 1280 compounds, (Sigma) - $... Show more »

Screening of the library of your choice, and database formation

Typical screening of drug discovery libraries (105,000 drug-like molecules) takes 4-5 weeks depending on the assay type.
Three libraries of known bioactive compounds can be screened in one day at very affordable price*:
LOPAC, 1280 compounds, (Sigma) - $ 360.00
Spectrum, 2000 compounds, (MicroSource Discovery Systems) - $ 530.00
TocriScreen Total, 1120 compounds, (Tocris Bioscience) - $ 320.30
*- the prices shown are only estimates, and do not include the cost of plastic and reagents.
SMSC has capabilities to employ the wide range of cell based and biochemical assays (Fluorescence intensity, Fluorescence polarization, TRF, FRET, Luminescence and enhanced luminescence, Absorbance, AlphaScreen). Original screening data will be stored on the facility computers. We guarantee the confidentiality of this data. The resulting data can be delivered in the raw format or converted into the database format selected by investigator.

Hit selection and validation

Selected hits will be validated using the screening assay. We will build a dose dependence profile for each hit in serial dilutions starting with the concentration used during screening. Accurate IC50 values can be determined for selected hits upon request.

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Assay Development
Starting at $808.04 per run

Assay will be tested (sensitivity, variability, reproducibility), modified and adjusted to work in HTS format and statistically validated (Z-factor). It includes the pilot screening of 1,600 compounds.

*All prices are estimates and can be adjusted depending on the particular procedures the project requires.

Assay will be tested (sensitivity, variability, reproducibility), modified and adjusted to work in HTS format and statistically validated (Z-factor). It includes the pilot screening of 1,600 compounds.

*All prices are estimates and can be adjusted depending on the particular procedures the project requires.

« Show less
Experimental Design
Price on request
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Project Management, Consulting, & Support Services
Price on request
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Hit Identification
Price on request
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Drug Discovery & Development
Price on request
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Drug Discovery
Price on request
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